| 191538-87-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 191538-87-1
• 化学式: C₁₉H₁₆O₅
• 分子量: 324.333
• InChiKey: DGEPFPYYIYTRHU-IAGOWNOFSA-N

物化性质

• 沸点：
  463.3±45.0 °C(Predicted)
• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.98
• 重原子数：
  24.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  61.83
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  在 N-碘代丁二酰亚胺 、 偶氮二异丁腈 、 三正丁基氢锡 、 sodium methylate 作用下， 以 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 3.0h， 生成 threothymidine
  参考文献：
  名称：

  An efficient and highly stereoselective synthesis of nucleoside derivatives from furanoid 1,2-diols

  摘要：

  Reaction between suitably protected furanoid glycals 1b-4b, readily obtained from furanoid 1,2-diols (1a-4a), and different silylated pyrimidine bases, gave the corresponding 3',5'- and 3',5',6'-O-protected 2'-deoxy-2'-iodo-beta-D-xylo-pentofuranosyl 5-10 and beta-D-gluco-hexofuranosyl 11 nucleosides, respectively. Compound 5 has been transformed into its 2'-deoxy 12 and 2',3'-anhydro 14 derivatives. The high stereoselectivity of the reaction is discussed. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00332-7
• 作为产物：
  描述：

  1,2-O-异亚丙基-alpha-D-呋喃木糖 在 吡啶 、 咪唑 、 硫酸 、 碘 、 溶剂黄146 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and comparative evaluation of two antiviral agents: β-l-Fd4C and β-d-Fd4C

  摘要：

  The synthesis of beta-D-Fd(4)C was achieved in a stereoselective fashion fi om D-xylose. The antiviral activity and cytotoxicity of beta-D-Fd(4)C was compared with that of beta-L-Fd(4)C and 3TC (Lamivudine). Of the three agents compared, beta-L-Fd(4)C was found to be the most potent antiviral agent. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00599-x

文献信息

• Synthesis of furanose glycals from furanose 1,2-diols and their cyclic thiocarbonate esters
  作者：Rafael Robles Diaz、Concepción Rodríguez Melgarejo、Isidoro Izquierdo Cubero、María T. Plaza López-Espinosa

  DOI：10.1016/s0008-6215(97)00072-4

  日期：1997.5

  Two new methods for the synthesis of furanoid glycals are described. Both procedures were shown to be faster and cheaper that those previously reported. Protected 1,2-dihydroxypento- and hexo-furanose derivatives with the D-xylo, D-gluco and D-riba, D-allo configurations were used as starting material to afford the corresponding C-3,4 D-threo and D-erythro glycals derivatives. (C) 1997 Elsevier Science Ltd.
• Bioorg. Med. Chem. Lett. 1998, 8, 3245-3250
  作者：

  DOI：——

  日期：——