ethyl 10-hydroxyoctadecanoate | 119003-47-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 10-hydroxyoctadecanoate
• 英文别名: 10-hydroxy-octadecanoic acid ethyl ester；10-Hydroxy-octadecansaeure-aethylester；10-Hydroxy-stearinsaeure-aethylester；ι-Oxy-stearinsaeure-aethylester；10-Hydroxy-ethylstearat
• CAS: 119003-47-3
• 化学式: C₂₀H₄₀O₃
• 分子量: 328.536
• InChiKey: ZMKUOTNYLGGUKL-UHFFFAOYSA-N

物化性质

• 沸点：
  414.3±18.0 °C(Predicted)
• 密度：
  0.912±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  23
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 10-hydroxyoctadecanoate 在 sodium butanolate 、 Petroleum ether 作用下， 生成 十八烷-1,10-二醇
  参考文献：
  名称：

  Seck; Dittmar, Chemische Umschau auf dem Gebiet der Fette, Oele, Wachse und Harze, 1932, vol. 39, p. 228

  摘要：

  DOI：
• 作为产物：
  描述：

  癸二酸 在 sodium tetrahydroborate 、 氯化亚砜 、 乙醇 、 硫酸 作用下， 以 环己烷 、 水 、 苯 为溶剂， 反应 28.5h， 生成 ethyl 10-hydroxyoctadecanoate
  参考文献：
  名称：

  位置异构体对其分子凝胶，分散体和固态中外消旋羟基十八烷酸聚集体的宏观和纳米结构的影响

  摘要：

  研究了一系列羟基硬脂酸（HSA）的分子间/分子间氢键。由这些具有异构羟基的脂肪酸获得的分子凝胶的自组装受到仲羟基位置的影响。如FT-IR所示，2-羟基硬脂酸（2HSA）不会形成分子二聚体，并且由于仲羟基无法形成分子间的H键，因此沿仲轴的生长受到抑制。同样，XRD长间隔短于羟基硬脂酸的二聚体长度。3-羟基硬脂酸（3HSA）形成无环二聚体，并且羟基无法氢键结合，从而阻止了晶体结构沿副轴生长。最后，异构体6HSA，8HSA，10HSA，12HSA和14HSA具有相似的XRD和FT-IR模式，这表明这些分子都以相似的方式自组装。单体形成羧基环状二聚体，并且仲羟基促进沿仲轴的生长。

  DOI：

  10.1021/la204412t

文献信息

• [EN] METHOD OF REDUCING SPOILAGE IN HARVESTED PRODUCE DURING STORAGE AND SHIPPING<br/>[FR] PROCÉDÉ DE RÉDUCTION DE LA DÉTÉRIORATION DE PRODUITS RÉCOLTÉS PENDANT LE STOCKAGE ET L'EXPÉDITION
  申请人：APEEL TECH INC

  公开号：WO2017172951A1

  公开（公告）日：2017-10-05

  Described herein are formulations and methods of reducing spoilage in harvested produce by reducing the rate of water or mass loss, thereby resulting in high quality produce with lower rates of spoilage. The present disclosure provides coatings and methods of coating produce to prevent moisture loss from produce during storage and shipment of the produce. This in turn allows the produce to be shipped and stored at lower relative humidity (e.g., lower than industry standards for shipment and storage, or lower than about 90% relative humidity), which can help delay the growth of biotic stressors such as fungi, bacteria, viruses, and/or pests.

  本文描述了一种减少收获农产品变质的配方和方法，通过减少水分或质量的流失速率，从而获得质量高、变质率低的农产品。本文提供了覆盖物和覆盖农产品的方法，以防止农产品在储存和运输过程中失去水分。这反过来允许农产品在较低的相对湿度下运输和储存（例如低于行业运输和储存标准或低于约90%的相对湿度），这可以延迟生物胁迫因素（如真菌、细菌、病毒和/或害虫）的生长。
• PROCESSES FOR PRODUCING LACTONE
  申请人：Takasago International Corporation

  公开号：EP1538215A1

  公开（公告）日：2005-06-08

  This invention relates to a method for producing a lactone comprising culturing Candida sorbophila in a medium containing at least one selected from the group consisting of a hydroxy fatty acid, a hydroxy fatty acid derivative, and a hydrolysate of a hydroxy fatty acid derivative and recovering the produced lactone from the medium. This invention also relates to a method for producing a lactone comprising culturing Candida sorbophila in a medium containing at least one selected from the group consisting of a hydroxy fatty acid, a hydroxy fatty acid derivative, and a hydrolysate of a hydroxy fatty acid derivative and lactonizing the lactone precursor hydroxy fatty acid produced in the medium.

  本发明涉及一种生产内酯的方法，该方法包括在含有至少一种选自由羟基脂肪酸、羟基脂肪酸衍生物和羟基脂肪酸衍生物的水解物组成的组中的一种的培养基中培养山梨糖念珠菌，并从培养基中回收生成的内酯。本发明还涉及一种生产内酯的方法，该方法包括在含有至少一种选自由羟基脂肪酸、羟基脂肪酸衍生物和羟基脂肪酸衍生物的水解物组成的培养基中培养山梨糖念珠菌，并对培养基中产生的内酯前体羟基脂肪酸进行内酯化。
• PLANT EXTRACT COMPOSITIONS FOR FORMING PROTECTIVE COATINGS
  申请人：Apeel Technology, Inc.

  公开号：EP3649860A1

  公开（公告）日：2020-05-13

  Described herein are methods of preparing cutin-derived monomers, oligomers, or combinations thereof from cutin-containing plant matter. The methods can include heating the cutin-derived plant matter in a solvent at elevated temperature and pressure. In some preferred embodiments, the methods can be carried out without the use of additional acidic or basic species.

  本文描述了从含有角叉菜胶的植物物质中制备角叉菜胶衍生单体、低聚物或其组合的方法。这些方法可包括在溶剂中以升高的温度和压力加热植物角质素衍生物质。在一些优选的实施方案中，这些方法可以在不使用额外的酸性或碱性物质的情况下进行。
• Processes for producing lactone
  申请人：Mitsuhashi Katsuhisa

  公开号：US20050130278A1

  公开（公告）日：2005-06-16

  This invention relates to a method for producing a lactone comprising culturing Candida sorbophila in a medium containing at least one selected from the group consisting of a hydroxy fatty acid, a hydroxy fatty acid derivative, and a hydrolysate of a hydroxy fatty acid derivative and recovering the produced lactone from the medium. This invention also relates to a method for producing a lactone comprising culturing Candida sorbophila in a medium containing at least one selected from the group consisting of a hydroxy fatty acid, a hydroxy fatty acid derivative, and a hydrolysate of a hydroxy fatty acid derivative and lactonizing the lactone precursor hydroxy fatty acid produced in the medium.

  本发明涉及一种生产内酯的方法，包括培养 白色念珠菌 在含有至少一种选自由羟基脂肪酸、羟基脂肪酸衍生物和羟基脂肪酸衍生物的水解产物组成的组的培养基中培养，并从培养基中回收产生的内酯。本发明还涉及一种生产内酯的方法，包括培养 白色念珠菌 在含有至少一种选自羟基脂肪酸、羟基脂肪酸衍生物和羟基脂肪酸衍生物水解物的培养基中培养，并将培养基中产生的内酯前体羟基脂肪酸内酯化。
• Anti—Interleukin-6 Antibodies Attenuate Inflammation in a Rat Meningitis Model
  作者：David Marby、Gregory R. Lockhart、Richard Raymond、James G. Linakis

  DOI：10.1111/j.1553-2712.2001.tb01090.x

  日期：2001.10

  Abstract Objectives: Interleukin‐6 (IL‐6) is elevated in the cerebrospinal fluid (CSF) of humans and animals with bacterial meningitis. This study's hypothesis was that anti‐IL‐6 antibodies will attenuate meningeal inflammation in a rat model of bacterial meningitis. Methods: 14 male Sprague‐Dawley rats were inoculated intracisternally (IC) with 0.1 mL of heat‐killed pneumococci. At one hour post‐inoculation, the rats received intraperitoneal doses of either 1.0 mL phosphate‐buffered saline (PBS treatment group, n? 7) or 70 μg anti‐IL‐6 antibodies in 1.0 mL PBS (anti‐IL‐6 antibody treatment group, n? 7). Nine rats (normal group, n? 9) had no inoculation, and four rats (surgical sham group, n? 4) had IC inoculations of saline. At six hours post‐inoculation, all the animals had CSF removed via IC tap. The CSF protein and white blood cell (WBC) count measures were compared using a t‐test. Results: Mean CSF WBC for the anti‐IL‐6 treatment group was 2,458/μL, versus the PBS controls' mean of 9,697/μL (p ? 0.007). Mean CSF protein for the anti‐IL‐6 group was 180 mg/dL, versus 296 mg/dL for the controls (p ? 0.032). The surgical sham and normal animals had normal CSF WBC and protein values. Conclusions: In this rat meningitis model, systemic treatment with anti‐IL‐6 antibodies after the induction of meningitis suppressed both CSF WBC count and CSF protein level, two important indices of meningeal inflammation.