Novel compounds are provided having formula (I) and salts thereof, where R1 is hydrogen, an alkyl, aralkyl, hydroxymethyl, carboxymethyl, acyloxymethyl or trialkylsilyl group, or a group -CH2NR3R4 where N is a linking nitrogen atom and where (a) R3 and R4 are independently selected from hydrogen and alkyl, alkenyl, hydroxyalkyl and alkoxyalkyl groups; (b) R3 is hydrogen or an alkyl, alkenyl, hydroxyalkyl or alkoxyalkyl group, and R4 is -COR5 where R5 is hydrogen or an alkyl, alkenyl, hydroxyalkyl or alkoxyalkyl group; or (c) R3 and R4 taken together with the linking nitrogen atom form a saturated 3- to 7-member heterocyclic group. These compounds are useful intermediates in a process to prepare camptothecin derivatives including the anti-cancer drug irinotecan.
提供具有式(I)及其盐的新化合物,其中R1为
氢,烷基,芳基烷基,
羟甲基,羧
甲基,酰
氧甲基或三烷基
硅基团,或者是一个-CH2NR3R4基团,其中N是连接
氮原子,且(a)R3和R4独立选择自
氢和烷基,
烯基,羟基烷基和烷
氧基烷基团;(b)R3为
氢或烷基,
烯基,羟基烷基或烷
氧基烷基团,而R4为-COR5,其中R5为
氢或烷基,
烯基,羟基烷基或烷
氧基烷基团;或者(c)R3和R4与连接
氮原子一起形成饱和的3-至7-成员杂环基团。这些化合物是制备
喜树碱衍
生物包括抗癌药物
伊立替康的过程中有用的
中间体。