6-N-benzoyl-9-(2-O-acetyl-3-C-phenylselenocarbonyl-β-D-xylofuranosyl)adenine | 188486-42-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 6-N-benzoyl-9-(2-O-acetyl-3-C-phenylselenocarbonyl-β-D-xylofuranosyl)adenine
• 英文别名: [(2R,3R,4S,5R)-2-(6-benzamidopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)-4-phenylselanylcarbonyloxolan-3-yl] acetate
• CAS: 188486-42-2
• 化学式: C₂₆H₂₃N₅O₇Se
• 分子量: 596.458
• InChiKey: KIYGPYYAKWKTCM-YLVSURIYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.19
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  166
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  6-N-benzoyl-9-(2-O-acetyl-3-C-phenylselenocarbonyl-β-D-xylofuranosyl)adenine 在 三正丁基氢锡 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以84%的产率得到N6-苯甲酰基腺嘌呤
  参考文献：
  名称：

  Studies on the Mechanism of Ribonucleotide Reductases

  摘要：

  Ribonucleotide reductases are enzymes that catalyze the conversion of ribonucleotides to 2'-deoxyribonucleotides. This important reaction is initiated by the generation of a C-3' nucleotide radical and subsequent loss of the 2'-hydroxyl group. In order to model certain steps in this mechanism, selenol ester 23 was prepared and photolyzed providing the first selective chemical access to the 3'-adenosyl radical. From product analysis it could be shown that elimination of the 2'-OH function readily takes place under general base catalysis. The rate coefficient for this reaction was determined by competition kinetics to be 1.5 . 10(6) s(-1) in the presence of 1 M triethylammonium acetate buffer at pH 7. Without catalyst the elimination rate is about 10(3) times slower. It can be concluded that a similar mechanism is also feasible for the key steps of the enzyme catalyzed reaction.

  DOI：

  10.1021/ja962974q
• 作为产物：
  描述：

  6-N-benzoyl-9-(2-O-acetyl-3,5-O-isopropylidene-3-C-phenylselenocarbonyl-β-D-xylofuranosyl)adenine 在 水 、 三氟乙酸 作用下， 反应 0.5h， 以86%的产率得到6-N-benzoyl-9-(2-O-acetyl-3-C-phenylselenocarbonyl-β-D-xylofuranosyl)adenine
  参考文献：
  名称：

  Studies on the Mechanism of Ribonucleotide Reductases

  摘要：

  Ribonucleotide reductases are enzymes that catalyze the conversion of ribonucleotides to 2'-deoxyribonucleotides. This important reaction is initiated by the generation of a C-3' nucleotide radical and subsequent loss of the 2'-hydroxyl group. In order to model certain steps in this mechanism, selenol ester 23 was prepared and photolyzed providing the first selective chemical access to the 3'-adenosyl radical. From product analysis it could be shown that elimination of the 2'-OH function readily takes place under general base catalysis. The rate coefficient for this reaction was determined by competition kinetics to be 1.5 . 10(6) s(-1) in the presence of 1 M triethylammonium acetate buffer at pH 7. Without catalyst the elimination rate is about 10(3) times slower. It can be concluded that a similar mechanism is also feasible for the key steps of the enzyme catalyzed reaction.

  DOI：

  10.1021/ja962974q