2-palmitoylamino-2-deoxy-D-glucose | 54627-18-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-palmitoylamino-2-deoxy-D-glucose
• 英文别名: N-D-Glucose-2-yl-palmitamid；2-Palmitoylamino-2-desoxy-D-glucose；N-palmitoyl-D-glucosamine；N-[(2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl]hexadecanamide
• CAS: 54627-18-8
• 化学式: C₂₂H₄₃NO₆
• 分子量: 417.587
• InChiKey: BEMSBNWZTWVGGA-YVNJGZBMSA-N

物化性质

• 熔点：
  196 °C
• 沸点：
  663.1±55.0 °C(Predicted)
• 密度：
  1.080±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  29
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  D-氨基葡萄糖盐酸盐 、 棕榈酰氯 在 四氢呋喃 、 水 、 碳酸氢钠 作用下， 生成 2-palmitoylamino-2-deoxy-D-glucose
  参考文献：
  名称：

  Synthetic Emulsifying Agents

  摘要：

  DOI：

  10.1021/ja01593a049

文献信息

• EXTERNAL PREPARATION
  申请人：Lion Corporation

  公开号：EP1543821A1

  公开（公告）日：2005-06-22

  Provided is an external preparation composition used for preventing or treating symptoms or diseases related to dermatopathy caused by dryness, UV rays and aging such as wrinkles and sags of the skin, pigmentation of the skin, skin roughness and coarse texture and skin diseases such as psoriasis, lichen, ichthyosis, keratosis, Darier's disease, pustulosis, acne, eczema and atopic dermatitis. The above external preparation composition is characterized by comprising at least one of acyl glucosamine derivatives represented by the following Formula (I): wherein R1, R2, R3 and R4 represent a hydrogen atom, a saturated or unsaturated, linear or branched fatty acid residue having 2 to 36 carbon atoms or a linear or branched alkyl group having 1 to 4 carbon atoms which may have a hydroxyl group, and they may be the same or different each other; R5 represents a hydrogen atom or a linear or branched alkyl group having 1 to 4 carbon atoms which may have a hydroxyl group; X is any one of groups represented by the following Formulas (A) to (C): wherein Y in the formulas (A) and (B) described above represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms in which an ether group may be interposed between a bond; and n represents an integer of 0 to 10; and R6 represents a linear or branched alkyl group or alkenyl group having 11 to 36 carbon atoms which may have a substituent.

  本发明提供了一种外用制剂组合物，用于预防或治疗与干燥、紫外线和老化引起的皮肤病有关的症状或疾病，如皮肤皱纹和下垂、皮肤色素沉着、皮肤粗糙和纹理粗糙以及皮肤病，如银屑病、苔癣、鱼鳞病、角化病、达里尔病、脓疱病、痤疮、湿疹和特应性皮炎。 上述外用制剂组合物的特点是包含至少一种由下式（I）代表的酰基氨基葡萄糖衍生物： 其中 R1、R2、R3 和 R4 代表氢原子、具有 2 至 36 个碳原子的饱和或不饱和、直链或支链脂肪酸残基或具有 1 至 4 个碳原子且可带有羟基的直链或支链烷基，它们彼此可以相同或不同；R5 代表氢原子或具有 1 至 4 个碳原子且可带有羟基的直链或支链烷基；X 是由下式（A）至（C）代表的基团中的任意一个： 其中 Y 在上述式（A）和式（B）中代表氢原子或具有 1 至 5 个碳原子的烷基，其中一个键之间可夹有一个醚基；n 代表 0 至 10 的整数；R6 代表具有 11 至 36 个碳原子的直链或支链烷基或烯基，其中可带有一个取代基。
• A pharmaceutical composition for the treatment of pathologies caused by the general response of the immune system
  申请人：Epitech Group S.r.l.

  公开号：EP1844784A1

  公开（公告）日：2007-10-17

  The present invention relates to a pharmaceutical composition consisting of amides of mono- and dicarboxylic acids and hydroxystilbenes, and may be used for the treatment of pathologies caused, sustained and/or characterised by an abnormal general response of the immune system, in both humans and animals.

  本发明涉及一种由单羧酸和二羧酸酰胺以及羟基二苯乙烯组成的药物组合物，可用于治疗人和动物因免疫系统总体反应异常而引起、持续和/或特征性的病症。
• External preparation composition
  申请人：Lion Corporation

  公开号：EP1917956A2

  公开（公告）日：2008-05-07

  A composition for application to skin comprising (a) an N-retinoyl-D-glucosamine compound wherein the retinoyl group contains at least 0.5% of cis-isomer; and (b) a percutaneous absorption accelerator.

  一种用于皮肤的组合物，包含 (a) 一种 N-视黄醇酰-D-葡萄糖胺化合物，其中视黄醇酰基含有至少 0.5% 的顺式异构体；以及 (b) 一种经皮吸收促进剂。
• Dental compositions including organogelators, products, and methods
  申请人：3M Innovative Properties Company

  公开号：EP2377507A2

  公开（公告）日：2011-10-19

  The present invention relates to a hardenable dental composition comprising: (a) an organic polymerizable component; (b) an organogelator, wherein the organogelator is a urea-type organogelator or a sugar-based compound; and (c) a filler material comprising nanoscopic particles or a crystalline material.

  本发明涉及一种可硬化牙科组合物，该组合物包括 (a) 有机可聚合组分； (b) 有机凝胶剂，其中有机凝胶剂为脲型有机凝胶剂或糖基化合物；以及 (c) 由纳米颗粒或结晶材料组成的填充材料。
• N-PALMITOYL-D-GLUCOSAMINE IN A MICRONIZED FORM
  申请人：Innovet Italia S.r.l.

  公开号：EP3546469A1

  公开（公告）日：2019-10-02

  The present invention relates to an N-palmitoyl-D-glucosamine-based composition in a micronized form, optionally in combination with Curcumin. In particular, the present invention relates to N-palmitoyl-D-glucosamine in a micronized or co-micronized form with Curcumin. Such a product can be formulated in human or veterinary pharmaceutical compositions, dietetic products, food supplements, or foods for special medical purposes (FSMP), or in feeds, or nutritional supplements for animals for the treatment of chronic systemic inflammatory diseases, in humans and animals, resulting from dysfunctions of epithelia and synovial membranes.

  本发明涉及一种微粉化形式的 N-棕榈酰-D-葡糖胺组合物，可选择与姜黄素结合使用。 特别是，本发明涉及微粉化或与姜黄素共同微粉化形式的 N-棕榈酰-D-葡糖胺。这种产品可配制成人用或兽用药物组合物、膳食产品、食品补充剂或特殊医学用途食品（FSMP），或配制成饲料或动物营养补充剂，用于治疗人和动物因上皮和滑膜功能障碍而引起的慢性全身性炎症性疾病。