(S)-(+)-1-[α-(4-biphenylyl)benzyl]-1H-imidazole | 91487-86-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-(+)-1-[α-(4-biphenylyl)benzyl]-1H-imidazole
• 英文别名: (S)-bifonazole；bifonazole；1-[(S)-phenyl-(4-phenylphenyl)methyl]imidazole
• CAS: 91487-86-4
• 化学式: C₂₂H₁₈N₂
• 分子量: 310.398
• InChiKey: OCAPBUJLXMYKEJ-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  、 (S)-(+)-1-[α-(4-biphenylyl)benzyl]-1H-imidazole 在 air 作用下， 以 氯仿 为溶剂， 生成 Co(O(C4NH2C(C6H5))3H(OH)C4NH2C6H4C2NO)((S)-bifonazole)
  参考文献：
  名称：

  卟啉钴（II）转化为无环五吡咯的螺旋钴（III）配合物

  摘要：

  拧紧螺丝的步骤：添加配位基并暴露于O 2时，卟啉配体的Co II配合物具有侧基邻氨基苯甲酰侧基转变为具有无环五吡咯配体的螺旋Co III配合物（参见图片，Co粉红色） ，N蓝色，O红色，C灰色）。分离并表征了复合物的对映异构体，并证明了通过添加手性碱可优先诱导（M）-螺旋复合物。

  DOI：

  10.1002/anie.201102144
• 作为产物：
  描述：

  (S)-(-)-α-(4-biphenylyl)benzylamine 在 ammonium acetate 、 potassium carbonate 作用下， 以 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 (S)-(+)-1-[α-(4-biphenylyl)benzyl]-1H-imidazole
  参考文献：
  名称：

  Chiral Azole Derivatives. 4.¹ Enantiomers of Bifonazole and Related Antifungal Agents:  Synthesis, Configuration Assignment, and Biological Evaluation

  摘要：

  DOI：

  10.1021/jo991937p

文献信息

• Practical Syntheses of Enantiomerically PureN-Acetylbenzhydrylamines
  作者：Daniele Castagnolo、Gianluca Giorgi、Raffaella Spinosa、Federico Corelli、Maurizio Botta

  DOI：10.1002/ejoc.200700193

  日期：2007.8

  Two practical routes for the synthesis of benzhydrylamine derivatives in enantiomerically pure form have been developed. N-Acetylbenzhydrylamines can be synthesised in few steps and good yields starting from 1-aryl-1-propargylamines. The key steps are represented by the alkene-alkyne cross metathesis reaction and alkyne–diene methylene-free tandem-metathesis reaction; these reactions have been performed

  已经开发了两种合成对映体纯形式的二苯甲基胺衍生物的实用路线。N-乙酰二苯甲基胺可以从 1-芳基-1-炔丙基胺开始，通过几个步骤和良好的产率合成。关键步骤以烯烃-炔烃交叉复分解反应和炔-二烯无亚甲基串联复分解反应为代表；这些反应是在微波辐射下在几分钟内完成的，产率很高。N-乙酰二苯甲基胺也被转化为抗真菌剂联苯苄唑的两种对映异构体，强调了这些化合物作为合成对映纯形式的生物活性化合物的支架的重要性。 (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim,德国，2007）
• Method and apparatus for the production of ionic cloths for use in ionic dressings
  申请人：RICOH KYOSAN INC.

  公开号：EP0395476A2

  公开（公告）日：1990-10-31

  Novel wound dressings and methods and systems for preparing them are provided herein. The wound dres­sing includes a substrate at least part of which is cellulosic and which has been chemically modified to have ionic-adsorbing sulfate sites thereon. A ca­tionic form of a physiologically- or biologically-­active agent is adsorbed therein. Upon contact with body exudate from wounds to which such wound dress­ing is applied, the physiologically- or biologi­cally-active agent is released in a controlled man­ner by ion exchange with the ions in the exudate, in proportion to the amount of the exudate. This is due to the fact that the adsorption is by means of an ionic bond. The strength of such ionic bond is such that the controlled release is achieved. This controlled release thus reduces unnecessary exposure of unwounded skin surface to the physiologically-or biologically-active agent. Commercially-viable me­thods and systems are also provided for producing substrates for the production of such wound dress­ings. The method includes the steps of soaking the substrate by passing the substrate through a bath of an appropriate chemical reactant solution, and squeezing the excess solution from the soaked sub­strate to provide a wetted substrate. In the im­proved method, the following additional steps are carried out, namely, the wetted substrate is sup­ported on a suitable backing member which sub­stantially inhibits the escape of such solution from the environment of the wetted substrate, preferably by first cutting the wetted substrate to a selected length. The so-supported substrate is cured in a heating means to provide the derivatized substrate. The so-cured derivatized substrate is washed. Fi­nally, the washed derivatized substrate is suitably dried.

  本文提供了新型伤口敷料及其制备方法和系统。伤口敷料包括一种基质，其中至少有一部分是纤维素，并经过化学改性，使其具有离子吸附硫酸盐位点。其中吸附有生理或生物活性剂的阳离子形式。在与伤口渗出物接触时，生理活性剂或生物活性剂会通过与渗出物中的离子进行离子交换，以可控的方式释放出来，释放量与渗出物的量成比例。这是因为吸附是通过离子键进行的。这种离子键的强度可以实现控制释放。因此，这种控制释放可减少未受伤皮肤表面不必要地接触生理或生物活性剂。还提供了商业上可行的方法和系统，用于生产这种伤口敷料的基材。该方法包括以下步骤：通过适当的化学反应剂溶液槽浸泡基质，并从浸泡的基质中挤出多余的溶液，以提供润湿的基质。在改进的方法中，还进行了以下步骤，即把浸湿的基片支撑在适当的支撑件上，该支撑件基本上能抑制溶液从浸湿基片的环境中逸出，最好是先把浸湿的基片切割成选定的长度。如此支撑的基底在加热装置中固化，以提供衍生化基底。将固化后的衍生基底进行洗涤。最后，将洗净的衍生化基底适当干燥。
• EXTERNAL PREPARATION FOR CURING LESIONED TISSUES
  申请人：Chuyakuken, Ltd.

  公开号：EP0923935A1

  公开（公告）日：1999-06-23

  A locally administrable preparation for treating affected tissues effective particularly for the affected tissues caused in the rectum or the anus, which contains a pharmaceutically effective component compounds including tannic acid and potassium aluminum sulfate and a base component for use with the locally administrable preparation. The locally administrable preparation is in the form of, for example, ointment, cream, and suppository.

  一种可局部给药的制剂，用于治疗受影响的组织，特别是对直肠或肛门引起的受影响组织有效，该制剂含有一种药效成分化合物，包括鞣酸和硫酸铝钾，以及一种与可局部给药的制剂配合使用的基质成分。可局部给药的制剂有软膏、乳膏和栓剂等形式。
• Pharmaceutical preparations containing highly volatile silicones
  申请人：EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG

  公开号：US10441660B2

  公开（公告）日：2019-10-15

  The subject of the present invention is a transdermal preparation containing pharmaceutically active ingredient, wherein the particles of the active ingredient are coated with highly volatile silicones or a mixture thereof, and these coated particles are dispersed in a gel or cream base. The volatile silicone component is hexamethyldisiloxane and/or octamethyltrisiloxane and/or decamethylpentacyclo-siloxane. A further subject of the present invention is a method for the preparation of such pharmaceutical compositions.

  本发明的主题是一种含有药物活性成分的透皮制剂，其中活性成分的颗粒被高挥发性硅酮或其混合物包覆，这些被包覆的颗粒分散在凝胶或乳霜基质中。挥发性有机硅成分为六甲基二硅氧烷和/或八甲基三硅氧烷和/或十甲基五环硅氧烷。本发明的另一个主题是制备此类药物组合物的方法。
• Composition for removing abnormal keratinous material
  申请人：——

  公开号：US20020197291A1

  公开（公告）日：2002-12-26

  The present invention discloses a pharmaceutical preparation comprising urea, a hydrophilic film-forming agent, water and/or a water-alcohol mixture that is suitable for the removal of abnormal keratinous material.

  本发明公开了一种药物制剂，由尿素、亲水性成膜剂、水和/或水醇混合物组成，适用于去除异常角质材料。