5(4)-methyl-4(5)-(2-hydroxyethyl)imidazole | 54732-98-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5(4)-methyl-4(5)-(2-hydroxyethyl)imidazole
• 英文别名: 4-(2-hydroxyethyl)-5-methyl-1H-imidazole；5-methyl-1H-imidazole-4-ethanol；2-(5-methyl-1(3)H-imidazol-4-yl)-ethanol；2-(5-Methyl-1(3)H-imidazol-4-yl)-aethanol；2-(5-Methyl-4-imidazolyl)ethanol；4-methyl-1H-Imidazole-5-ethanol；2-(5-methyl-1H-imidazol-4-yl)ethanol
• CAS: 54732-98-8
• 化学式: C₆H₁₀N₂O
• mdl: MFCD21336094
• 分子量: 126.158
• InChiKey: ASCUVHKNQDPJNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5(4)-methyl-4(5)-(2-hydroxyethyl)imidazole 在 氢溴酸 作用下， 反应 96.0h， 以51%的产率得到4-(2-bromoethyl)-5-methyl-1H-imidazole hydrobromide
  参考文献：
  名称：

  Cardiotonic agents. 6. Histamine analogs as potential cardiovascular selective H2 agonists

  摘要：

  Twenty-six alkyl and aralkyl histamine analogues were prepared as potential cardiotonic agents. Compounds were designed to allow interaction with a putative secondary aryl binding site at the H2 receptor, the presence of which was inferred from the structure of cyprohepatadine, which is known to have H2-antagonist properties. The compounds were examined for inotropic activity in ferret papillary muscle. Potent inotropic activity was generally found in N-alkyl- and N,N-dialkylimidazole-4-ethanamines, whereas N-(amidoalkyl)imidazole-4-ethanamines and N-alkylimidazole-4-propanamines were at best weakly active. Five compounds were examined in screens designed to assess hemodynamic effects and gastric acid secretion in vivo. Two of these compounds, alpha-(3-phenyl-2-transpropenyl)-1H-imidazole-4-ethanamine and N-heptyl-1H-imidazole-4-ethanamine, showed positive inotropic activity with minimal effects on heart rate and mean arterial pressure in vivo; however, both compounds were found to stimulate gastric acid secretion. These results demonstrate that selectivity between various H2-receptor-mediated activities can be obtained with substituted histamine analogues.

  DOI：

  10.1021/jm00168a024
• 作为产物：
  描述：

  4-(2-hydroxy-ethyl)-5-methyl-1,3-dihydro-imidazole-2-thione 在 水 、 三氯化铁 作用下， 生成 5(4)-methyl-4(5)-(2-hydroxyethyl)imidazole
  参考文献：
  名称：

  Thiamin Analogs. IV.¹ 4(5)-Methyl-5(4)-(β-hydroxyethyl)-imidazole

  摘要：

  DOI：

  10.1021/ja01219a506

文献信息

• [EN] INDANE, DIHYDROBENZOFURAN, AND TETRAHYDRONAPHTHALENE CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS<br/>[FR] DERIVES D'ACIDE CARBOXYLIQUE D'INDANE, DE DIHYDROBENZOFURANE ET DE TETRAHYDRONAPHTHALENE ET LEURS UTILISATIONS COMME ANTIDIABETIQUES
  申请人：BAYER PHARMACEUTICALS CORP

  公开号：WO2004011446A1

  公开（公告）日：2004-02-05

  This invention relates to novel indane, dihydrobenzofuran, and tetrahydronaphthalene carboxylic acid derivatives whice are useful in the treatment of diseases such sa diabetes, diabetes-related disorders, obesity, hyperlipidemia, and cardiovascular diseases. The invention also relates to intermediates useful in preparation of said carboxylic derivatives and to methods of preparation.

  这项发明涉及新型茚烷、二氢苯并呋喃和四氢萘羧酸衍生物，这些衍生物在治疗疾病如糖尿病、与糖尿病相关的疾病、肥胖症、高脂血症和心血管疾病方面具有用处。该发明还涉及有助于制备所述羧酸衍生物的中间体以及制备方法。
• Processes for preparing imidazole derivatives and salts thereof
  申请人：YUHAN CORPORATION

  公开号：US20030153769A1

  公开（公告）日：2003-08-14

  The present invention provides a process for preparing an imidazole derivative or its salt which comprises reacting a tetrahydrofuran or tetrahydropyran derivative with formamidine or its salt in the presence of a base.

  本发明提供了一种制备咪唑衍生物或其盐的方法，包括在碱存在下，将四氢呋喃或四氢吡喃衍生物与甲酰胺或其盐反应。
• Photographic processing composition and processing method
  申请人：Fuji Photo Film Co., Ltd.

  公开号：EP0907104A2

  公开（公告）日：1999-04-07

  There is disclosed a photographic processing composition, which comprises an aminopolycarboxylic acid compound of the formula (I) or a ferric complex salt thereof: wherein R1 to R10 each represent a hydrogen atom, a hydroxyl group or the like; W represents a linking group, M1 to M4 each represent a hydrogen atom or the like, t and u each represent an integer of 1 to 6; and S indicates that the absolute configuration of an asymmetric carbon is the S-configuration. The photographic processing composition exhibits storage stability. There is also disclosed a method of processing a silver halide light-sensitive material, which comprises using the photographic processing composition. The method can improve insufficiency of color formation, fading, and the like.

  本发明公开了一种照相冲洗组合物，它包括式（I）的氨基多羧酸化合物或其铁络合盐： 其中 R1 至 R10 分别代表氢原子、羟基或类似物；W 代表连接基团；M1 至 M4 分别代表氢原子或类似物；t 和 u 分别代表 1 至 6 的整数；S 表示不对称碳的绝对构型为 S 构型。该照相冲洗组合物具有储存稳定性。本发明还公开了一种处理卤化银感光材料的方法，其中包括使用该感光冲洗组合物。该方法可以改善成色不足、褪色等问题。
• Beiträge zu dem Problem der Ähnlichkeit in der Chemie I
  作者：H. Erlenmeyer、D. Waldi、E. Sorkin

  DOI：10.1002/hlca.19480310109

  日期：——
• Pfister, Juerg R.; Kurz, Walter; Harrison, Ian T., Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 831 - 832
  作者：Pfister, Juerg R.、Kurz, Walter、Harrison, Ian T.

  DOI：——

  日期：——