N-(2-氯吡啶-3-基)甲磺酰胺 | 158955-23-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: N-(2-氯吡啶-3-基)甲磺酰胺
• 英文名称: N-(2-chloropyridin-3-yl)methane Sulfonamide
• 英文别名: N-(2-chloro-3-pyridyl)methanesulfonamide；N-(2-chloropyridin-3-yl)methanesulfonamide
• CAS: 158955-23-8
• 化学式: C₆H₇ClN₂O₂S
• mdl: MFCD03394600
• 分子量: 206.653
• InChiKey: LWNKSGMYPMZZRL-UHFFFAOYSA-N

物化性质

• 沸点：
  340.8±52.0 °C(Predicted)
• 密度：
  1.529±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(2-氯吡啶-3-基)甲磺酰胺 在 sodium hydroxide 、 potassium tert-butylate 、 四丁基溴化铵 、 potassium carbonate 作用下， 以 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.42h， 生成 N-[2-(1-cyclopentenyl)-3-pyridyl]-N-methylamine
  参考文献：
  名称：

  Reactions of Pyridine Analogues of Aza-ortho-xylylenes Generated from 1,3-Dialkylpyridosultams

  摘要：

  2,3-Dihydro-3-imino-2-methylenepyridines generated by thermal extrusion of SO2 from 1,3-dialkyl-1,3-dihydroisothiazolo[4,3-b]pyridine 2,2-dioxides (1,3-dialkylpyridosultams), underwent [1,5] hydrogen shifts, which led to 3-alkylamino-2-vinylpyridine derivatives. Cycloalkanespiro-3-pyridosultams 12, which were easily obtained by alkylation of pyridosultams with alpha,omega-dihaloalkanes, gave, in a similar reaction, 3-alkylamino-2-cycloalkenylpyridine derivatives 14 in good yields. Cyclobutanespiro-3-pyridosultam 12b, after thermal extrusion of SO2, formed cyclobutenyl derivative 14b, which underwent a ring-opening reaction to form butadiene derivative 15. The latter can be trapped with dienophiles, for example, N-phenylmaleimide.

  DOI：

  10.1002/1099-0690(200004)2000:7<1263::aid-ejoc1263>3.0.co;2-e
• 作为产物：
  描述：

  N-(2-氯吡啶-3-基)-N-(甲基磺酰基)甲磺酰胺 在 10percent NaOH 作用下， 以 水 为溶剂， 反应 0.5h， 以14.9 g的产率得到N-(2-氯吡啶-3-基)甲磺酰胺
  参考文献：
  名称：

  Reactions of Pyridine Analogues of Aza-ortho-xylylenes Generated from 1,3-Dialkylpyridosultams

  摘要：

  2,3-Dihydro-3-imino-2-methylenepyridines generated by thermal extrusion of SO2 from 1,3-dialkyl-1,3-dihydroisothiazolo[4,3-b]pyridine 2,2-dioxides (1,3-dialkylpyridosultams), underwent [1,5] hydrogen shifts, which led to 3-alkylamino-2-vinylpyridine derivatives. Cycloalkanespiro-3-pyridosultams 12, which were easily obtained by alkylation of pyridosultams with alpha,omega-dihaloalkanes, gave, in a similar reaction, 3-alkylamino-2-cycloalkenylpyridine derivatives 14 in good yields. Cyclobutanespiro-3-pyridosultam 12b, after thermal extrusion of SO2, formed cyclobutenyl derivative 14b, which underwent a ring-opening reaction to form butadiene derivative 15. The latter can be trapped with dienophiles, for example, N-phenylmaleimide.

  DOI：

  10.1002/1099-0690(200004)2000:7<1263::aid-ejoc1263>3.0.co;2-e

文献信息

• Benzimidazoles that are useful in treating sexual dysfunction
  申请人：——

  公开号：US20020169166A1

  公开（公告）日：2002-11-14

  The present invention relates to the use of compounds of formula (I) 1 for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

  本发明涉及使用式(I)的化合物治疗性功能障碍，以及含有式(I)化合物的组合物用于治疗性功能障碍。
• Generation and reactions of heteroanalogues of aza-ortho-xylylenes
  作者：Krzysztof Wojciechowski、Szymon Kosiński

  DOI：10.1016/s0040-4039(97)00962-3

  日期：1997.6

  N-alkyl-1,3-dihydroisothiazolo[4,3-b]pyridine 2,2-dioxides (pyridosultams, 8), which undergo thermal extrusion of SO2 giving heteroanalogues of aza-ortho-xylylenes 9. These reactive 1-azadienes enter [4+2] cycloaddition with dienophiles leading to tetrahydro[1,5]naphthyridines 11. With an excess of dienophile (N-phenylmaleimide) pyridoazocine derivatives 12 and 13 being 2:1 adducts are formed.

  2-氯-3-（链烷磺酰基氨基）吡啶中氯的分子内亲核取代提供了N-烷基-1,3-二氢异噻唑并[4,3- b ]吡啶2,2-二氧化物（pyridosultams，8），将其热挤出SO 2给出氮杂邻二甲苯9的杂类似物。这些反应性的1-氮杂二烯与亲二烯体一起进入[4 + 2]环加成反应，生成四氢[1,5]萘啶11。通过过量的亲双烯体（N-苯基马来酰亚胺），形成2∶1的吡啶并偶氮碱衍生物12和13加合物。
• Reactions of Pyridine Analogues of Aza-o-xylylenes Generated from 1,3-Dihydroisothiazolo[4,3-b]pyridine 2,2-Dioxides (Pyridosultams) − Formation of 2:1 Adducts withN-Phenylmaleimide
  作者：Krzysztof Wojciechowski、Szymon Kosinski

  DOI：10.1002/1099-0690(200203)2002:5<947::aid-ejoc947>3.0.co;2-n

  日期：2002.3

  Pyridine analogues 16−20 of aza-o-xylylenes, generated from pyridosultams 11−15, enter into Diels−Alder reactions with dienophiles to form 1,2,3,4-tetrahydronaphthyridines 23−28, which then add another equivalent of a dienophile to form 2:1 adducts 29−36. Intramolecular Diels−Alder reactions of aza-o-xylylenes 45 and 46, generated from pyridosultams 43 and 44, produced tricyclic pyrrolo- and pyridonaphthyridines

  吡啶类似物 16-20 氮杂-邻二甲苯，从 pyridosultams 11-15 产生，进入 Diels-Alder 反应与亲二烯体形成 1,2,3,4-四氢萘啶 23-28，然后加入另一个当量的亲二烯体形成 2:1 加合物 29−36。由 pyridosultams 43 和 44 产生的氮杂-邻二甲苯 45 和 46 的分子内 Diels-Alder 反应产生三环吡咯并和吡啶并萘啶 47 和 48，用于构建 10,14-二氮杂甾骨架 54.52 和(© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)
• Benzimidazoles that are useful in treating male sexual dysfunction
  申请人：Abbott Laboratories

  公开号：US07022728B2

  公开（公告）日：2006-04-04

  The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

  本发明涉及使用式(I)化合物治疗性功能障碍以及含有式(I)化合物的组合物治疗性功能障碍。
• PIPERAZINYLPYRIDINYL WATER CLATHRATES
  申请人：THE UPJOHN COMPANY

  公开号：EP0690848A1

  公开（公告）日：1996-01-10