甲酰基琥珀酸二甲酯 | 58026-12-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 甲酰基琥珀酸二甲酯
• 英文名称: dimethyl formylsuccinate
• 英文别名: dimethyl 2-formylsuccinate；dimethyl 2-formylbutanedioate
• CAS: 58026-12-3
• 化学式: C₇H₁₀O₅
• 分子量: 174.153
• InChiKey: RYFFRHSMYJVFER-UHFFFAOYSA-N

物化性质

• 沸点：
  112-115 °C(Press: 12 Torr)
• 密度：
  1.170±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2918300090

反应信息

• 作为反应物：
  描述：

  甲酰基琥珀酸二甲酯 在 potassium hydrogensulfate 、 sodium methylate 作用下， 以 氯仿 、 xylene 为溶剂， 生成 α-Acetaminomethylen-α'-aethylmercaptomethylen-bernsteinsaeuredimethylester
  参考文献：
  名称：

  Lingens,F.; Hankwitz,R., Justus Liebigs Annalen der Chemie, 1963, vol. 670, p. 31 - 47

  摘要：

  DOI：
• 作为产物：
  描述：

  丁二酸二甲酯 在 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 12.0h， 生成 甲酰基琥珀酸二甲酯
  参考文献：
  名称：

  [EN] OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS
  [FR] OXADIAZOLONES EN TANT QU'INHIBITEURS DE CANAL POTENTIEL RÉCEPTEUR TRANSITOIRE

  摘要：

  该发明涉及式(I)的化合物及其药用可接受的盐。此外，本发明涉及制备方法和使用式(I)的化合物的方法，以及含有这种化合物的药物组合物。这些化合物可能在治疗由TRPA1介导的疾病和症状，如疼痛方面有用。

  公开号：

  WO2018096159A1

文献信息

• Peptide nucleic acids having 2,6-diaminopurine nucleobases
  申请人：——

  公开号：US06414112B1

  公开（公告）日：2002-07-02

  A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8 alkylamine side chains.

  一种新型化合物类别，被称为肽核酸，比相应的DNA链和RNA链结合更牢固，并表现出增强的序列特异性和结合亲和力。该发明的肽核酸包括从天然存在的核碱基和连接到聚酰胺骨架的非天然核碱基中选择的配体。该发明的一些肽核酸还包含C1-C8烷基胺侧链。
• Peptide nucleic acids having enhanced binding affinity, sequence
  申请人：——

  公开号：US05714331A1

  公开（公告）日：1998-02-03

  A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain C.sub.1 -C.sub.8 alkylamine side chains. Methods of enhancing the solubility, binding affinity and sequence specificity of PNAs are provided.

  一种新型化合物，被称为肽核酸，比相应的DNA链和RNA链结合更牢固，并表现出增强的序列特异性和溶解性。肽核酸包括从天然存在的核碱基和连接到聚酰胺骨架的非天然存在的核碱基中选择的配体，并含有C.sub.1 -C.sub.8烷基胺侧链。提供了增强PNAs溶解性、结合亲和力和序列特异性的方法。
• Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
  申请人：——

  公开号：US06710164B1

  公开（公告）日：2004-03-23

  A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains.

  一种被称为肽核酸的新型化合物类别，能够结合互补的DNA和RNA链，通常比相应的DNA或RNA链结合更牢固，同时表现出增强的序列特异性和溶解性。肽核酸包括从天然存在的核碱基和非天然存在的核碱基（包括2,6-二氨基嘌呤）中选择的配体，这些配体连接在聚酰胺骨架上，并含有烷基胺侧链。
• Peptide nucleic acids
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US06451968B1

  公开（公告）日：2002-09-17

  Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be orientated either parallel or antiparallel to each other.

  新型肽核酸和新型连接的肽核酸与核酸形成三股结构。肽核酸包括配体，例如通过适当的连接剂连接到肽骨架上的天然存在的核碱基。其他核碱基包括C-嘧啶和异嘧啶可以用作胡金氏链中的配体，以增加结合亲和力。两条肽核酸链通过连接剂连接在一起形成双肽核酸。双肽核酸中肽核酸的各个链可以平行或反平行定向。
• Peptide nucleic acids having amino acid side chains
  申请人：——

  公开号：US05719262A1

  公开（公告）日：1998-02-17

  A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain alkylamine side chains.

  一种新型化合物，被称为肽核酸，比相应的DNA或RNA链更强烈地结合互补的DNA和RNA链，并表现出增强的序列特异性和溶解性。肽核酸包括从一组中选择的配体，该组包括天然存在的核碱基和连接到聚酰胺骨架的非天然存在的核碱基，并含有烷基胺侧链。