1,5-戊二醇二丙烯酸酯 | 36840-85-4

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1,5-戊二醇二丙烯酸酯
• 中文别名: 戊二醇丙烯酸双酯；环戊烷乙二醇二丙烯酸酯；1,5-双(丙烯酰氧基)戊烷；1,5-戊二醇丙烯酸双脂；5戊二醇二丙烯酸酯；1,5戊二醇二丙烯酸酯
• 英文名称: 1,5-pentanediol diacrylate
• 英文别名: 5-prop-2-enoyloxypentyl prop-2-enoate
• CAS: 36840-85-4
• 化学式: C₁₁H₁₆O₄
• mdl: MFCD00078444
• 分子量: 212.246
• InChiKey: XAMCLRBWHRRBCN-UHFFFAOYSA-N

物化性质

• 沸点：
  90-95 °C(Press: 0.1 Torr)
• 密度：
  1.024±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（轻微）、乙酸乙酯

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2916190090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335
• 储存条件：
  存于室温环境，密封保存，并确保干燥。

SDS

1,5-Bis(acryloyloxy)pentane (stabilized with MEHQ) Revision number: 6
SAFETY DATA SHEET

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Section 1. IDENTIFICATION
Product name: 1,5-Bis(acryloyloxy)pentane (stabilized with MEHQ)

Revision number: 6

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Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS Not classified
HEALTH HAZARDS
Skin corrosion/irritation Category 2
Category 2A
Serious eye damage/eye irritation
Skin sensitization Category 1
Not classified
ENVIRONMENTAL HAZARDS
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Signal word Warning
Hazard statements Causes skin irritation
Causes serious eye irritation
May cause an allergic skin reaction
Precautionary statements:
Avoid breathing dust/fume/gas/mist/vapours/spray.
[Prevention]
Contaminated work clothing should not be allowed out of the workplace.
Wash hands thoroughly after handling.
Wear protective gloves/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
[Response]
if present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF ON SKIN: Gently wash with plenty of soap and water.
If skin irritation or rash occurs: Get medical advice/attention.
Wash contaminated clothing before reuse.
Other hazards which do not May cause polimerization.
result in classification

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: 1,5-Bis(acryloyloxy)pentane (stabilized with MEHQ)
Percent: >97.0%(GC)
36840-85-4
CAS Number:
1,5-Bis(acryloyloxy)pentane (stabilized with
MEHQ)

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Synonyms: 1,5-Pentanediol Diacrylate (stabilized with MEHQ) , Pentamethylene Glycol
Diacrylate (stabilized with MEHQ)
Chemical Formula: C11H16O4

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
Protection of first-aiders: A rescuer should wear personal protective equipment, such as rubber gloves and air-
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Dry chemical, foam, water spray, carbon dioxide.
Suitable extinguishing
media:
Unsuitable extinguishing Solid streams of water
media:
Specific hazards arising This substance may polimerize explosively when heated or involved in a fire.
from the chemical: Container may explode when heated. Combat fire from a sheltered position.
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Keep containers cool by
spraying with water. Eliminate all ignition sources if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, Use personal protective equipment. Keep people away from and upwind of spill/leak.
protective equipment and Ensure adequate ventilation. Entry to non-involved personnel should be controlled
emergency procedures: around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in dry sand or inert absorbent before recovering it into a
containment and cleaning covered container. In case of large amount of spillage, contain a spill by bunding.
up: Adhered or collected material should be promptly disposed of, in accordance with
appropriate laws and regulations.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapour or mist. Wash hands and face thoroughly after
handling.
Use a ventilation, local exhaust if vapour or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions: Keep container tightly closed. Store in a cool and dark place.
Store away from incompatible materials such as oxidizing agents.
Packaging material: Comply with laws.
1,5-Bis(acryloyloxy)pentane (stabilized with
MEHQ)

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers should not be
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Vapor respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Safety glasses. A face-shield, if the situation requires.
Eye protection:
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Liquid
Clear
Form:
Colour: Very pale yellow - Pale yellow
No data available
Odour:
pH: No data available
Melting point/freezing point:No data available
Boiling point/range: 95°C/0.01kPa
Flash point: No data available
Flammability or explosive
limits:
Lower: No data available
Upper: No data available
Relative density: 1.04
Solubility(ies):
[Water] No data available
[Other solvents]
Soluble: Acetone

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Section 10. STABILITY AND REACTIVITY
Chemical stability: Polymerization may occur under the influences of heat, light or on contact with
polymelization initiators such as peroxides etc.
Possibility of hazardous No special reactivity has been reported.
reactions:
Conditions to avoid: Heat, Light
Incompatible materials: Oxidizing agents, Strong acids, Strong bases, Heavy metals
Hazardous decomposition Carbon monoxide, Carbon dioxide
products:

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Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity: No data available

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
No data available
Fish:
Crustacea: No data available
No data available
Algae:
Persistence / degradability: No data available
No data available
Bioaccumulative
potential(BCF):
1,5-Bis(acryloyloxy)pentane (stabilized with
MEHQ)

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Section 12. ECOLOGICAL INFORMATION
Mobility in soil
No data available
Log Pow:
Soil adsorption (Koc): No data available
No data available
Henry's Law
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when
disposing of the substance.

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Section 14. TRANSPORT INFORMATION
Does not correspond to the classification standard of the United Nations
Hazards Class:
UN-No: Not listed

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1,5-戊二醇二丙烯酸酯 在 溶剂黄146 作用下， 以 苯 为溶剂， 反应 4.0h， 生成 (RS)/meso-N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis-tetrahydropapaverine
  参考文献：
  名称：

  Stenlake; Waigh; Dewar, European Journal of Medicinal Chemistry, 1984, vol. 19, # 5, p. 441 - 450

  摘要：

  DOI：
• 作为产物：
  描述：

  戊烷-1,5-二基二(3-溴丙酸酯) 在 三乙胺 、 对苯二酚 作用下， 以 苯 为溶剂， 生成 1,5-戊二醇二丙烯酸酯
  参考文献：
  名称：

  抗肿瘤药。8.O，O′-双（丙烯酰基）-α，ω-链烷二醇的合成和细胞毒性活性。

  摘要：

  DOI：

  10.1002/jps.2600630734
• 作为试剂：
  描述：

  1,5-戊二醇二丙烯酸酯 、 R-tetrahydropapaverine N-acetyl-L-leucine 在 1,5-戊二醇二丙烯酸酯 作用下， 以99的产率得到3,4,4-三甲氧基哌啶-1-羧酸乙酯
  参考文献：
  名称：

  WO9200965A1

  摘要：

  公开号：

文献信息

• [EN] NOVEL R,R'-ATRACURIUM SALTS<br/>[FR] NOUVEAUX SELS DE R,R'-ATRACURIUM
  申请人：CHEMAGIS LTD

  公开号：WO2009057086A1

  公开（公告）日：2009-05-07

  The present invention provides R,R'-atracurium salts, processes for producing and purifying such salts, and methods of using such salts to produce highly pure cisatracurium besylate.

  本发明提供了R，R'-阿曲库铵盐，生产和纯化这种盐的方法，以及使用这种盐生产高纯度顺阿曲库铵苄甲酸盐的方法。
• Low molecular weight PEI-based polycationic gene vectors via Michael addition polymerization with improved serum-tolerance
  作者：Miao-Miao Xun、Ya-Ping Xiao、Ji Zhang、Yan-Hong Liu、Qi Peng、Qian Guo、Wan-Xia Wu、Yong Xu、Xiao-Qi Yu

  DOI：10.1016/j.polymer.2015.03.070

  日期：2015.5

  A series of polycationic gene delivery vectors were synthesized via Michael addition from low molecular weight PEI and linking compounds with various heteroatom compositions. Agarose gel electrophoresis results reveal that these polymers can well condense plasmid DNA and can protect DNA from degradation by nuclease. The formed polyplexes, which are stable toward serum, have uniform spherical nanoparticles

  通过迈克尔加成反应，从低分子量PEI合成一系列聚阳离子基因传递载体，并将化合物与各种杂原子组成连接。琼脂糖凝胶电泳结果表明，这些聚合物可以很好地凝聚质粒DNA，并可以保护DNA不受核酸酶降解。所形成的对血清稳定的多链体具有均匀的球形纳米颗粒，其适当大小约为200–350 nm，ζ电位约为+40 mV。体外实验表明，与25 KDa PEI相比，这些聚合物具有更低的细胞毒性和更高的转染效率。此外，标题材料表现出优异的血清耐受性。在存在10％血清的情况下，获得的转染效率是PEI的19倍，即使血清浓度增加到40％以上，也没有观察到TE的明显降低。流式细胞术和共聚焦显微镜研究也证明了该材料具有良好的血清耐受性。
• 一种苯磺顺阿曲库铵的制备方法及其应用
  申请人：江苏诚信药业有限公司

  公开号：CN112778200B

  公开（公告）日：2022-09-23

  本发明提供了一种苯磺顺阿曲库铵的制备方法及其应用，所述制备方法包括以下步骤：(1)将R‑四氢罂粟碱‑N‑乙酰‑L‑亮氨酸盐溶解，用碱性溶液调pH值，之后与3‑溴丙酸甲酯和碱混合反应，得到中间体A；(2)将步骤(1)得到的中间体A与碱混合反应，得到中间体B；(3)将步骤(2)得到的中间体B与甲基化试剂混合反应，得到中间体C；(4)将步骤(3)得到的中间体C、催化剂和脱水剂混合反应，得到所述苯磺顺阿曲库铵。本发明提供的制备方法生产过程安全，收率高，异构体少，最大单杂低。
• 一种苯磺顺阿曲库铵的纯化方法
  申请人：江苏诚信药业有限公司

  公开号：CN112979547B

  公开（公告）日：2022-10-21

  本发明提供一种苯磺顺阿曲库铵的纯化方法。所述苯磺顺阿曲库铵的纯化方法具体包括以下步骤：(1)将反应液浓缩后，采用硅胶柱层析纯化，并采用含苯磺酸的非醇溶剂进行洗脱，得到洗脱液；(2)将步骤(1)得到的洗脱液浓缩后，进行复溶和洗涤，得到粗纯化液；(3)将步骤(2)得到的粗纯化液浓缩后，进行复溶、脱色和干燥，得到苯磺顺阿曲库铵纯品。本发明所述纯化方法简单，更适合工业化，且由本发明所述方法纯化得到的苯磺顺阿曲库铵的HPLC纯度＞99.0％，最大已知杂质＜0.30％，最大未知杂质＜0.10％。
• 一种苯磺顺阿曲库铵杂质H的分离制备方法及其应用
  申请人：江苏诚信药业有限公司

  公开号：CN112939862B

  公开（公告）日：2023-01-10

  本发明提供了一种苯磺顺阿曲库铵杂质H的分离制备方法及其应用，所述分离制备方法包括以下步骤：(1)将苯磺顺阿曲库铵反应液减压浓缩至不滴，之后进行硅胶柱层析纯化洗脱；(2)步骤(1)所述硅胶柱层析纯化洗脱将苯磺顺阿曲库铵成品出料完毕后，改变洗脱液比例继续洗脱，收集洗脱液，得到所述苯磺顺阿曲库铵杂质H。本发明提供的分离制备方法得到的苯磺顺阿曲库铵杂质H纯度高，最大单杂低，用于苯磺顺阿曲库铵的质量控制中能够提高检测的准确度。