6-methoxy-8-quinolinethiolate hydrochloride | 24186-86-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-methoxy-8-quinolinethiolate hydrochloride
• 英文别名: 6-methoxy-8-quinolinethiol hydrochloride；6-methoxyquinoline-8-thiol;hydrochloride
• CAS: 24186-86-5
• 化学式: C₁₀H₉NOS*ClH
• 分子量: 227.714
• InChiKey: LIMVDPPWCCHBJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.95
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  23.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-methoxy-8-quinolinethiolate hydrochloride 在 K(SbO)C₄H₄O₆*0.5H₂O 作用下， 以 乙醇 、 水 为溶剂， 生成 Antimony(3+);6-methoxyquinoline-8-thiolate
  参考文献：
  名称：

  Synthesis and cytotoxicity of methyl-and methoxy-substituted metal 8-quinolinethiolates

  摘要：

  It has been found that the nature of the substituent, its position in the quinoline ring, and the nature of the metal significantly affect the antitumor activity and toxicity of metal 8-quinolinethiolates. The most cytotoxic towards human fibrosarcoma HT-1080 and mouse hepatoma MG-22A tumor cells are the 6-methoxy-8-quinolinethiolates of rhodium, osmium, iridium, indium, antimony, and bismuth, however these are highly toxic towards normal mouse embryonic NIH 3T3 fibroblasts. The iridium 5-methyl-8-quinolinethiolate is somewhat less active to MG-22A cells but shows quite good selectivity of action because of its markedly lower toxicity.

  DOI：

  10.1007/s10593-008-0075-8

文献信息

• Synthesis and cytotoxicity of complex compounds of tin, vanadium, and molybdenum with quinolinethiol and its methyl and methoxy derivatives
  作者：D. Zaruma、E. Lukevics、L. Ignatovich、I. Shestakova、I. Domracheva、V. Bridane、E. Yashchenko、J. Ashaks

  DOI：10.1007/s10593-012-0945-y

  日期：2012.3

  and majority of the complexes of 8-quinolinethiol derivatives possessed very high cytotoxicity towards both cell lines. Their toxicity in relation to mouse embryo fibroblasts NIH 3T3 depended on the position of the substituent in the quinoline ring. Complexes of tin and vanadium with 4-methyl-, 5-methyl-, and 6-methoxy-8-quinolinethiol derivatives were less toxic. 4-Methyl-, 5-methyl-, and 6-metho

  锡（II），钒（IV）的一系列8-喹啉硫醇盐和3-甲基-，4-甲基-，5-甲基，6-甲基-，7-甲基和6-甲氧基-8-喹啉硫醇盐），并且已经合成了钼（VI）。研究了它们对HT-1080肿瘤细胞（人纤维肉瘤）和MG-22A（小鼠肝癌）细胞的细胞毒性。已经确定，所有研究的8-喹啉硫醇配合物和大多数8-喹啉硫醇衍生物的配合物对两种细胞系都具有非常高的细胞毒性。它们对小鼠胚胎成纤维细胞NIH 3T3的毒性取决于取代基在喹啉环中的位置。锡和钒与4-甲基，5-甲基和6-甲氧基-8-喹啉硫醇衍生物的配合物毒性较小。4-甲基，5-甲基，