2-hydroxy-4-methoxy-trans(?)-chalcone | 108837-17-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-hydroxy-4-methoxy-trans(?)-chalcone
• 英文别名: 2-Hydroxy-4-methoxy-trans-chalkon；(E)-3-(2-Hydroxy-4-methoxyphenyl)-1-phenylprop-2-en-1-one
• CAS: 108837-17-8
• 化学式: C₁₆H₁₄O₃
• 分子量: 254.285
• InChiKey: JWIVHKKACZZAJX-CSKARUKUSA-N

物化性质

• 熔点：
  126-128 °C
• 沸点：
  454.2±45.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-hydroxy-4-methoxy-trans(?)-chalcone 在 sodium hydroxide 、 乙醇 、 双氧水 作用下， 生成 3-hydroxy-2-(4-methoxy-phenyl)-chroman-4-one
  参考文献：
  名称：

  Marathey, Journal of the University of Poona, Science and Technology, 1953, # 4, p. 73,78

  摘要：

  DOI：
• 作为产物：
  描述：

  7-methoxy-2-phenyl-chromenylium; chloride 在 溶剂黄146 作用下， 生成 2-hydroxy-4-methoxy-trans(?)-chalcone
  参考文献：
  名称：

  274.黄酮盐的结构

  摘要：

  DOI：

  10.1039/jr9350001161

文献信息

• Insoluble organic UV screening agents of aryl vinylene ketone type, and cosmetic use thereof
  申请人：——

  公开号：US20030053966A1

  公开（公告）日：2003-03-20

  The invention relates to insoluble organic compounds containing one or more aryl vinylene ketone groups, for screening out UV radiation, in the form of fine particles with an average size of between 10 nm and 5 &mgr;m, and also to their use for protecting the skin, the hair or materials that are sensitive to UV radiation. The said compounds may be obtained by a process of grinding coarse particles in the presence of one or more suitable surfactants.

  该发明涉及含有一个或多个芳基乙烯酮基团的不溶性有机化合物，用于筛选出紫外辐射，其形式为平均粒径在10纳米至5微米之间的细颗粒，并且用于保护皮肤、头发或对紫外辐射敏感的材料。所述化合物可通过在存在一个或多个适当表面活性剂的情况下研磨粗颗粒的方法获得。
• [EN] NOTCH INHIBITORS FOR USE IN THE TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA<br/>[FR] INHIBITEURS DE NOTCH DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE LA LEUCÉMIE LYMPHOBLASTIQUE AIGUË À LYMPHOCYTES T
  申请人：UNIV DEGLI STUDI ROMA LA SAPIENZA

  公开号：WO2018122689A1

  公开（公告）日：2018-07-05

  Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).

  式（I）的化合物作为具有抗肿瘤活性的化合物，用于治疗T细胞急性淋巴细胞白血病（T-ALL）。
• Highly enantioselective addition of aliphatic aldehydes to 2-hydroxychalcone enabled by cooperative organocatalysts
  作者：Jiadong Hu、Yu-Qi Gao、Dongyang Xu、Le Chen、Wen Wen、Yi Hou、Lu Chen、Weiqing Xie

  DOI：10.1039/d0cc04424e

  日期：——

  Herein, we developed an enantioselective addition of aliphatic aldehydes to 2-hydroxychalcone promoted by cooperative organocatalysts, giving access to hybrid flavonoids in excellent enantioselectivities. This reaction took advantage of cycloisomerization of 2-hydroxychalcone to form a transient flavylium under the irradiation of 24 W CFL, which was trapped by the in situ generated chiral enamine intermediate

  在这里，我们开发了脂族醛对2-羟基查尔酮的对映选择性加成反应，而2-羟基查耳酮则通过协同有机催化剂促进，从而以优异的对映选择性获得杂合类黄酮。该反应利用2-羟基查耳酮的环异构化在24 W CFL的照射下形成瞬时黄酮，其被原位产生的手性烯胺中间体捕获。通过与瞬时黄酮进行离子配对，手性磷酸的协同作用确保了该反应的出色结果。
• Synthesis of methylene cyclopropane-fused chromenes and dihydroquinolines by sequential [4 + 2]- and [1 + 2]-annulation
  作者：Tianyu Lu、Xuange Zhang、Zhiwei Miao

  DOI：10.1039/d0ob00389a

  日期：——

  A base promoted sequential [4 + 2]- and [1 + 2]-annulation of 2-hydroxychalcones or 2-tosylaminochalcones with prop-2-ynylsulfonium salts has been developed to give the corresponding methylene cyclopropane fused dihydroquinolines or chromenes in moderate to good yields. This transformation has advantage of wide substrate scope and functional group tolerance as well as excellent regioselectivity. Prop-2-ynylsulfonium

  已开发出具有碱促进的2-羟基查尔酮或2-甲苯磺酰基al与丙-2-炔基salts盐依次[4 + 2]-和[1 + 2]环化的方法，可得到中等至良好的相应亚甲基环丙烷稠合的二氢喹啉或色烯。产量。这种转变的优点是底物范围广，官能团耐受性好以及区域选择性好。丙-2-炔基salts盐在串联过程中同时充当C2和C1合成子。
• CYCLOPENTA[C]CHROMIUM COMPOUND AND PREPARATION METHOD THEREFOR
  申请人：SOOCHOW UNIVERSITY

  公开号：US20210147376A1

  公开（公告）日：2021-05-20

  The present invention discloses a cyclopenta[c]chromene compound and a preparation method thereof. A chalcone compound as a reactant, A cationic rare earth metal compound Ln(CH 3 CN) 9 ] 3+ [(AlCl 4 ) 3 ] 3− .CH 3 CN as a catalyst, and 2-naphthalenethiol as an accelerator, react in an organic solvent to prepare the cyclopenta[c]-chromene compound. Ln represents a positive trivalent rare earth metal ion, which is selected from the group consisting of La, Nd, Sm, Gd, and Yb. The starting materials are easy obtained, the reaction process is simple, and the yield of the target product is high, up to 85%.

  本发明揭示了一种环戊[c]色烯化合物及其制备方法。以查尔酮化合物为反应物，以阳离子稀土金属化合物Ln(CH3CN)9]3+[(AlCl4)3]3−.CH3CN为催化剂，以2-萘硫醇为促进剂，在有机溶剂中反应制备环戊[c]-色烯化合物。Ln代表正三价稀土金属离子，选自La、Nd、Sm、Gd和Yb等组。起始材料易于获得，反应过程简单，目标产品的产率高，高达85％。