4,4’-二羟基苯偶酰 | 33288-79-8

• 物质功能分类: 材料化学 - 配体
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 4,4’-二羟基苯偶酰
• 中文别名: 4,4'-二羟基苯偶酰；4,4'-二羟基二苯基乙二酮
• 英文名称: 4,4'-dihydroxybenzil
• 英文别名: 1,2-bis(4-hydroxyphenyl)ethane-1,2-dione；4,4’-dihydroxybenzil；4,4′-dihydroxy-benzil；4,4'-dihydroxydiphenyl ethylenedione
• CAS: 33288-79-8
• 化学式: C₁₄H₁₀O₄
• 分子量: 242.231
• InChiKey: FMYXOBBPXQZKKY-UHFFFAOYSA-N

物化性质

• 熔点：
  235 °C(Solv: water (7732-18-5))
• 沸点：
  500.4±35.0 °C(Predicted)
• 密度：
  1.366±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2914501900
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  室温下，应保存于惰性气体中。

反应信息

• 作为反应物：
  描述：

  4,4’-二羟基苯偶酰 在 potassium carbonate 、 氯化铵 、 锌 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成 4,4’-dihexyloxybenzoin
  参考文献：
  名称：

  (Z)-Tetraphenylbut-2-ene-1,4-diones: facile synthesis, tunable aggregation-induced emission and fluorescence acid sensing

  摘要：

  一种简便的方法来合成立体特异性的(Z)-芳基功能化1,4-烯酮已被提出。

  DOI：

  10.1039/c7tc00173h
• 作为产物：
  描述：

  脱氧茴香偶姻 在 氢溴酸 、 吡啶盐酸盐 、 溶剂黄146 、 copper(ll) bromide 作用下， 以 二甲基亚砜 、 乙酸乙酯 为溶剂， 反应 13.0h， 生成 4,4’-二羟基苯偶酰
  参考文献：
  名称：

  Hyperbranched Polyphenylquinoxalines from Self-Polymerizable AB₂ and A₂B Monomers

  摘要：

  A self-polymerizable AB(2) monomer, 2,3-bis(4-hydroxyphenyl)-6-fluoroquinoxaline, and an A(2)B monomer, 2,3-bis(4-fluorophenyl)-6-(4-hydroxyphenoxy)quinoxaline, were prepared and polymerized to afford phenol-terminated and aryl fluoride terminated, hyperbranched polyphenylquinoxalines (HPPQs), respectively. MALDI-TOF analysis showed that intramolecular cyclization was a dominant process for the low molecular weight portion during the polymerizations. After isolation and complete dryness, the phenol-terminated HPPQ 1 was only soluble in strong organic acids, while the aryl fluoride terminated HPPQ 2 was soluble in most common organic solvents. HPPQ 1 was treated with allyl bromide to afford an allyl ether terminated HPPQ 3, which was also soluble in most organic solvents. Intrinsic viscosity measurements and SEC analysis indicated that HPPQ 2 had a much higher M-w and a much broader molecular weight distribution (PDI similar to 60) than HPPQ 1 and HPPQ 3 (PDI similar to 4). The results also suggested that HPPQ 1 formed aggregates in solution and that HPPQ 2 had a much more extended and open conformation. All the HPPQs, which were highly fluorescent, had UV absorption maxima near 375 nm in THF. However, the wavelength of their emission maxima, which ranged from 424 to 466 nm, depended on their end groups.

  DOI：

  10.1021/ma0489467

文献信息

• Vasculostatic agents and methods of use thereof
  申请人：Wrasidlo Wolfgang

  公开号：US20050282814A1

  公开（公告）日：2005-12-22

  Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.

  提供了用于治疗与血管稳态受损相关的疾病的组合物和方法。发明的方法和组合物可用于治疗各种疾病，包括中风、心肌梗死、癌症、缺血/再灌注损伤、类风湿性关节炎等自身免疫疾病、眼部疾病如视网膜病变或黄斑变性或其他玻璃体视网膜疾病、炎症性疾病、血管渗漏综合征、水肿、移植排斥反应、成人/急性呼吸窘迫综合征（ARDS）等。
• Glycoluril core molecules for combinatorial libraries
  申请人：Rebek, Jr. Julius

  公开号：US06939973B1

  公开（公告）日：2005-09-06

  The present invention provides novel glycoluril derivatives for use as core molecules in combinatorial chemistry. Core molecules of the present invention can contain from one to six building blocks. Preferred building blocks are substituted amine radicals. Combinatorial libraries containing such core molecules are also provided.

  本发明提供了用作组合化学中核心分子的新型甘氨酰脲衍生物。本发明的核心分子可以包含从一个到六个构建块。首选的构建块是取代胺基团。还提供了含有这种核心分子的组合式文库。
• Plasminogen activator inhibitor antagonists
  申请人：Corvas International INC

  公开号：US06677473B1

  公开（公告）日：2004-01-13

  Compounds and pharmaceutical compositions useful as plasminogen activator inhibitor (PAI) antagonists are provided. In particular, methods of antagonizing PAI with substituted and unsubstituted aryl and heteroaryl ethers and thioethers, benzils, benzyl ethers, benzoate esters, sulfones and benzophenones are provided.

  提供了一种作为纤溶酶原激活剂抑制剂（PAI）拮抗剂的化合物和药物组合物。特别是，提供了用取代和未取代的芳基和杂芳基醚和硫醚、苯偶姻、苄基醚、苯甲酸酯、磺酰和苯甲酮拮抗PAI的方法。
• [EN] CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS<br/>[FR] COMPOSÉS DE NORBORNÉNONE LIBÉRANT DU MONOXYDE DE CARBONE
  申请人：SAMMUT IVAN ANDREW

  公开号：WO2017095237A1

  公开（公告）日：2017-06-08

  The present invention provides organic compounds which are capable of releasing carbon monoxide under physiological conditions or pH trigger, and to the use of such compounds for conditioning a cell, tissue or organ, for example, to protect against ischaemic injury during a transplant event.

  本发明提供了在生理条件或pH触发下能够释放一氧化碳的有机化合物，以及将这种化合物用于调节细胞、组织或器官，例如，在移植事件中保护免受缺血性损伤的使用方法。
• [EN] DENTAL COMPOSITION CONTAINING POLYOXOMETALATES, PROCESS OF PRODUCTION AND USE THEREOF<br/>[FR] COMPOSITION DENTAIRE CONTENANT DES POLYOXOMÉTALATES, PROCÉDÉS DE PRODUCTION ET D'UTILISATION DE LADITE COMPOSITION
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2015034977A1

  公开（公告）日：2015-03-12

  The invention relates to a curable composition for dental use comprising polyoxymetalates and/or derivatives thereof in an amount of at least about 5 wt.-% with respect to the weight of the composition.

  该发明涉及一种可治疗的牙科用组合物，其包括聚氧金属酸盐和/或其衍生物，其在组合物的重量上占至少约5重量百分比。