4,4’-二苯基二苯甲酮 | 3478-90-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4,4’-二苯基二苯甲酮
• 中文别名: 4,4'-联苯苯甲酮；4,4"-二苯基二苯甲酮；4,4"-二苯基苯甲酮
• 英文名称: 4,4'-diphenylbenzophenone
• 英文别名: Dibiphenylketon；bis(4-phenylphenyl)methanone
• CAS: 3478-90-8
• 化学式: C₂₅H₁₈O
• 分子量: 334.417
• InChiKey: QRQHCGWCUVLPSQ-UHFFFAOYSA-N

物化性质

• 熔点：
  228-229°C
• 沸点：
  523.7±39.0 °C(Predicted)
• 密度：
  1.121±0.06 g/cm3(Predicted)
• 稳定性/保质期：

  在常温常压下保持稳定

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 安全说明：
  S22,S24/25
• 海关编码：
  2914399090
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  常温、避光、通风干燥处，密封保存。

SDS

Version 1.0
Regulation (EC) No 1907/2006

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1 - Product and Company Information

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Product Name 4,4'-DIPHENYLBENZOPHENONE - 250 MG

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2 - Hazards Identification

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SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Not hazardous according to Directive 67/548/EEC.

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3 - Composition/Information on Ingredients

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Product Name CAS # EC no Annex I
Index Number
4,4'-DIPHENYLBENZOPHENONE 3478-90-8 None None
Formula C25H18O
Molecular Weight 334,4100 AMU

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4 - First Aid Measures

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AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.

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5 - Fire Fighting Measures

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EXTINGUISHING MEDIA
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Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.

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6 - Accidental Release Measures

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PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Exercise appropriate precautions to minimize direct contact with
skin or eyes and prevent inhalation of dust.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.

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7 - Handling and Storage

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HANDLING
Directions for Safe Handling: Avoid inhalation. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.

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8 - Exposure Controls / Personal Protection

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ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US)
or CEN (EU). Respiratory protection is not required. Where
protection from nuisance levels of dusts are desired, use type N95
(US) or type P1 (EN 143) dust masks.
Hand Protection: Protective gloves.
Eye Protection: Chemical safety goggles.

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9 - Physical and Chemical Properties

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Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 228,000. - 229,000 °
C.
Flash Point N/A
Flammability N/A
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Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
Partition Coefficient Log Kow: 6,748
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A

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10 - Stability and Reactivity

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STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur

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11 - Toxicological Information

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SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.

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12 - Ecological Information

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No data available.

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13 - Disposal Considerations

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SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.

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14 - Transport Information

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RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.

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15 - Regulatory Information

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Not hazardous according to Directive 67/548/EEC.
Caution: Substance not yet fully tested (EU).

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16 - Other Information

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WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2010 Co. License granted to make
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
ALDRICH www.molbase.com

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4,4’-二苯基二苯甲酮 在 乙醚 、 sodium 、 苯 作用下， 生成 2-羟基-2,2-二(4-苯基苯基)乙酸
  参考文献：
  名称：

  Tribology of MEMS

  摘要：

  由于大表面积与体积比以及低恢复力，不受欢迎的粘附和摩擦可能主导微电子机械系统（MEMS）设备的性能。为了确保MEMS设备的功能和可靠性，摩擦学家必须了解从宏观到分子级的广泛长度尺度范围内粘附、摩擦和磨损的起源。在本文中，我们概述了挑战、成功以及朝着基本理解迈出的初步步骤。

  DOI：

  10.1557/mrs2001.65
• 作为产物：
  描述：

  bis(4-biphenylyl)methane 在 manganese(IV) oxide 作用下， 生成 4,4’-二苯基二苯甲酮
  参考文献：
  名称：

  Oxidation by Solids. II. The Preparation of Either Tetraarylethanes or Diaryl Ketones by the Oxidation of Diarylmethanes with Manganese Dioxide

  摘要：

  DOI：

  10.1021/jo01038a009

文献信息

• Photoreactive Composition, Reaction Product, and Method of Producing Reaction Product
  申请人：Tokyo University of Science Foundation

  公开号：US20210253826A1

  公开（公告）日：2021-08-19

  A photoreactive composition including a base-reactive compound, a photobase generator that is represented by the following Formula (1) and that generates a base when irradiated with light, and at least one compound selected from the group consisting of a polycyclic aromatic compound having a fused ring structure having two or more rings and a polycyclic aromatic compound having three or more aromatic rings and having a conjugated structure including any two or more of the three or more aromatic rings, in which the base-reactive compound is a compound having two or more groups that will have their polarity converted by the action of a base and that exhibit reactivity, in one molecule, or a compound having two or more groups that will react under the action of a base, in one molecule.

  一种光反应性组合物，包括一种基反应性化合物，一种由以下化学式（1）表示的光碱发生剂，在受光照射时生成碱，并且从以下组中选择的至少一种化合物：具有具有两个或两个以上环的融合环结构的多环芳香化合物，以及具有三个或三个以上芳香环并具有包括三个或三个以上芳香环中的任意两个或两个以上的共轭结构的多环芳香化合物，其中基反应性化合物是一种具有两个或两个以上基团的化合物，这些基团将通过碱的作用转变极性并表现出反应性，在一个分子中，或者是一种具有两个或两个以上基团的化合物，在一个分子中在碱的作用下发生反应。
• [EN] NICOTINE-BASED COMPOUNDS USEFUL FOR ASYMMETRIC SYNTHESIS<br/>[FR] COMPOSÉS À BASE DE NICOTINE UTILES POUR UNE SYNTHÈSE ASYMÉTRIQUE
  申请人：UNIV NORTH CAROLINA STATE

  公开号：WO2010040059A1

  公开（公告）日：2010-04-08

  Chiral amino alcohol and amino phosphine compounds are provided herein, which compounds are useful for asymmetric synthesis.

  这里提供了手性氨醇和氨基膦化合物，这些化合物对于不对称合成是有用的。
• Photochemical phenylation and oxidation of halogen-substituted di-phenylmethanes in benzene
  作者：G. E. Robinson、J. M. Vernon

  DOI：10.1039/j39700002586

  日期：——

  Several chloro- and bromo-diphenylmethanes are photolysed in benzene under nitrogen to the corresponding phenylated and reduced compounds. Photolysis in presence of air gives additionally ketonic products, whose formation is explained in terms of a halogen-catalysed photo-oxidation reaction.

  数种氯和溴代二苯甲烷在氮气氛下在苯中光解为相应的苯基化和还原的化合物。在空气存在下的光解还产生了酮类产物，其形成是通过卤素催化的光氧化反应来解释的。
• Photochromic naphthopyran compounds
  申请人：Vision-Ease Lens, Inc.

  公开号：US06337409B1

  公开（公告）日：2002-01-08

  A naphthopyran compound represented by the formula: wherein R4, R5, R6, R7, R8, R9, R10, and R11 are each selected from the group consisting essentially of hydrogen, a first stable organic radical, a heterocyclic group, halogen, a first nitrogen-substituted group, and a first nitrogen-substituted ring compound; A and B are each selected from the group consisting essentially of hydrogen, substituted phenyl, and substituted naphthyl, provided that at least one of A or B is substituted phenyl or substituted naphthyl; and any substituent of any substituted phenyl or substituted naphthyl at A or B is selected from the group consisting essentially of hydrogen, a second stable organic radical, a heterocyclic group, halogen, a second nitrogen-substituted group, and a second nitrogen-substituted ring compound, provided that at least one substituent of any substituted phenyl or substituted naphthyl at either A or B is phenyl, naphthyl, or furyl.

  一种以以下式表示的萘吡喃化合物： 其中R4、R5、R6、R7、R8、R9、R10和R11分别选自氢、第一稳定有机自由基、杂环基团、卤素、第一氮取代基团和第一氮取代环化合物组成的群体；A和B分别选自氢、取代苯基和取代萘基的群体，前提是A或B中至少有一个是取代苯基或取代萘基；在A或B处的任何取代苯基或取代萘基的任何取代基选自氢、第二稳定有机自由基、杂环基团、卤素、第二氮取代基团和第二氮取代环化合物组成的群体，前提是在A或B处的任何取代苯基或取代萘基的至少一个取代基是苯基、萘基或呋喃基。
• Site-selective D₂O-mediated deuteration of diaryl alcohols <i>via</i> quantum dots photocatalysis
  作者：Xiao-Lei Nan、Yao Wang、Xu-Bing Li、Chen-Ho Tung、Li-Zhu Wu

  DOI：10.1039/d1cc02551a

  日期：——

  Owing to the high synthetic value of deuteration in the pharmaceutical industry, we describe herein the conversions of a range of aromatic ketones to deuterium-labeled products in good to excellent yields.

  由于氘在制药工业中具有很高的合成价值，我们在本文中描述了一系列芳香酮转化为氘标记产物的转化，产率良好至优秀。