[2-(3-Formyl-4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester | 220686-71-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [2-(3-Formyl-4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[2-(3-formyl-4-hydroxyphenyl)ethyl]carbamate
• CAS: 220686-71-5
• 化学式: C₁₄H₁₉NO₄
• 分子量: 265.309
• InChiKey: OTJPRLHRUAQIEL-UHFFFAOYSA-N

物化性质

• 沸点：
  415.6±40.0 °C(Predicted)
• 密度：
  1.167±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [2-(3-Formyl-4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 在 sodium hydroxide 作用下， 以 甲醇 、 二甲基亚砜 为溶剂， 生成 tert-butyl N-[2-[4-(3-imidazol-1-ylpropyl)-5-(2-methoxyethylcarbamoyl)-3-oxo-5H-1,4-benzoxazepin-7-yl]ethyl]carbamate
  参考文献：
  名称：

  Unique Structures Generated by Ugi 3CC Reactions Using Bifunctional Starting Materials Containing Aldehyde and Carboxylic Acid

  摘要：

  DOI：

  10.1021/jo982192a
• 作为产物：
  描述：

  氯仿 、 N-Boc-酪胺 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 7.0h， 以49%的产率得到[2-(3-Formyl-4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  [EN] QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION
  [FR] AMPLIFICATION DU SIGNAL D'ANALOGUES DE QUINONEMÉTHIDES

  摘要：

  本文披露了一种新型的醌甲烯类似物前体，以及使用该前体的方法和套件的实施例，用于检测生物样本中的一个或多个靶标。检测方法包括将样本与检测探针接触，然后将样本与包含酶的标记共轭物接触。酶与包含可检测标记的醌甲烯类似物前体相互作用，形成具有可检测标记的反应性醌甲烯类似物，该类似物与生物样本中的靶标近距离或直接结合。然后检测可检测标记。在某些实施例中，通过多个醌甲烯类似物前体与不同酶相互作用，无需酶去活化步骤即可检测多个靶标。

  公开号：

  WO2015124703A1

文献信息

• Chemical Synthesis of Proteins with Base‐Labile Posttranslational Modifications Enabled by a Boc‐SPPS Based General Strategy Towards Peptide C‐Terminal Salicylaldehyde Esters
  作者：Wenjie Ma、Hongxiang Wu、Sha Liu、Tongyao Wei、Xiang David Li、Han Liu、Xuechen Li

  DOI：10.1002/anie.202214053

  日期：2023.1.2

  A Boc-SPPS based method towards the synthesis of peptide C-terminal salicylaldehyde esters compatible with all canonical amino acids was developed. The method could facilitate the synthesis of proteins bearing base-labile post-translational modifications, e.g., O-acetylation and S-palmitoylation.

  开发了一种基于 Boc-SPPS 的方法来合成与所有规范氨基酸相容的肽 C 末端水杨醛酯。该方法可以促进带有碱不稳定翻译后修饰的蛋白质的合成，例如，O-乙酰化和S-棕榈酰化。
• QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION
  申请人：Ventana Medical Systems, Inc.

  公开号：EP3492919A2

  公开（公告）日：2019-06-05

  Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a biological sample. The method of detection comprises contacting the sample with a detection probe, then contacting the sample with a labeling conjugate that comprises an enzyme. The enzyme interacts with a quinone methide analog precursor comprising a detectable label, forming a reactive quinone methide analog, which binds to the biological sample proximally to or directly on the target. The detectable label is then detected. In some embodiments, multiple targets can be detected by multiple quinone methide analog precursors interacting with different enzymes without the need for an enzyme deactivation step.

  本文公开了新型醌甲醚类似物前体，以及使用其检测生物样本中一个或多个目标的方法和试剂盒的实施方案。检测方法包括将样品与检测探针接触，然后将样品与包含酶的标记共轭物接触。酶与含有可检测标签的甲喹酮类似物前体相互作用，形成反应性甲喹酮类似物，该类似物与生物样本中的目标物近距离结合或直接结合在目标物上。然后检测可检测标签。在某些实施方案中，多个醌甲酰类似物前体与不同的酶相互作用，可检测多个靶标，而无需酶失活步骤。
• Quinone methide analog signal amplification
  申请人：Ventana Medical Systems, Inc.

  公开号：US10168336B2

  公开（公告）日：2019-01-01

  Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a biological sample. The method of detection comprises contacting the sample with a detection probe, then contacting the sample with a labeling conjugate that comprises an enzyme. The enzyme interacts with a quinone methide analog precursor comprising a detectable label, forming a reactive quinone methide analog, which binds to the biological sample proximally to or directly on the target. The detectable label is then detected. In some embodiments, multiple targets can be detected by multiple quinone methide analog precursors interacting with different enzymes without the need for an enzyme deactivation step.

  本文公开了新型醌甲醚类似物前体，以及使用其检测生物样本中一个或多个目标的方法和试剂盒的实施方案。检测方法包括将样品与检测探针接触，然后将样品与包含酶的标记共轭物接触。酶与含有可检测标签的甲喹酮类似物前体相互作用，形成反应性甲喹酮类似物，该类似物与生物样本中的目标物近距离结合或直接结合在目标物上。然后检测可检测标签。在某些实施方案中，多个醌甲酰类似物前体与不同的酶相互作用，可检测多个靶标，而无需酶失活步骤。
• Oxone-mediated dakin reaction of benzaldehydes to phenols
  作者：Tomoya Nobuta、Kiriko Funayama、Tomoko Mineno

  DOI：10.1016/j.jics.2024.101186

  日期：2024.8

  We report the Dakin reaction using Oxone as a mild and green oxidant. This protocol does not require acidic additives or transition metal catalysts. It effectively operates on salicylaldehyde and benzaldehyde substrates, yielding catechols and phenols in moderate to high yields.

  我们报告了使用 Oxone 作为温和的绿色氧化剂的 Dakin 反应。该方案不需要酸性添加剂或过渡金属催化剂。它可以有效地作用于水杨醛和苯甲醛底物，以中等到高产率产生儿茶酚和苯酚。
• STRONG BINDING METAL-CHELATING RESINS USING MACROCYCLE MOLECULES
  申请人：Sachem, Inc.

  公开号：US20220380520A1

  公开（公告）日：2022-12-01

  A metal-chelating resin includes (a) a compound represented by Formula (I): or a stereoisomeric form thereof or a salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R a , R b , R c and R d are as defined herein; and (b) an organic polymer resin having at least one complementary reactive functional group covalently linked with at least one linking group of the compound represented by Formula (I).