[G0]-PGLSA-bzld | 374107-87-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: [G0]-PGLSA-bzld
• 英文别名: Bis(2-phenyl-1,3-dioxan-5-yl) butanedioate
• CAS: 374107-87-6
• 化学式: C₂₄H₂₆O₈
• 分子量: 442.466
• InChiKey: JIMZODIEMMQWPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  89.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  [G0]-PGLSA-bzld 在 Pd(OH)2/C (10% w/w) 氢气 作用下， 以 四氢呋喃 为溶剂， 反应 10.0h， 生成 [G0]-PGLSA-OH
  参考文献：
  名称：

  [EN] DENTRITIC POLYMERS, CROSSLINKED GELS, AND THEIR USES IN ORTHOPEDIC APPLICATIONS
  [FR] POLYMERES DENDRITIQUES ET GELS RETICULES: UTILISATIONS DANS DES APPLICATIONS ORTHOPEDIQUES

  摘要：

  公开号：

  WO2006031388A3
• 作为产物：
  描述：

  丁二酸 、 2-苯基-1,3-二氧六环-5-醇 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 14.0h， 以90%的产率得到[G0]-PGLSA-bzld
  参考文献：
  名称：

  [EN] DENDRITIC POLYMERS, CROSSLINKED GELS, AND THEIR USES AS OPHTHALMIC SEALANTS AND LENSES
  [FR] POLYMERES DENDRITIQUES, GELS RETICULES, ET LEURS UTILISATIONS COMME AGENTS DE SCELLEMENT ET LENTILLES OPHTALMIQUES

  摘要：

  公开号：

  WO2006031358A3

文献信息

• POLYMER CONJUGATED PROSTAGLANDIN ANALOGUES
  申请人：O'Shea Michael Shane

  公开号：US20140120058A1

  公开（公告）日：2014-05-01

  The present invention relates in general to polymer-drug conjugates. In particular, the invention relates to polymer-drug conjugates wherein the conjugated drugs are selected from prostaglandins and substituted prostaglandins, to a method of delivering such prostaglandin drugs to a subject, to a sustained drug delivery system comprising the polymer-drug conjugates, to a method of preparing the polymer-drug conjugates, and to an implant comprising the polymer-drug conjugates. The polymer-drug conjugates may be useful for delivering prostaglandins and substituted prostaglandins for the treatment of glaucoma.

  本发明通常涉及聚合物-药物共轭物。具体而言，本发明涉及聚合物-药物共轭物，其中共轭药物选自前列腺素和取代前列腺素，以及将这样的前列腺素药物传递给受体的方法，包括聚合物-药物共轭物的持续性药物传递系统，制备聚合物-药物共轭物的方法，以及包含聚合物-药物共轭物的植入物。聚合物-药物共轭物可用于传递前列腺素和取代前列腺素，用于治疗青光眼。
• Method of preparing dendritic drugs
  申请人：Chai Minghui

  公开号：US20070190151A1

  公开（公告）日：2007-08-16

  Synthetic design of drug-incorporated novel dendrimer structures for quantitatively controlled drug delivery. The dendritic drugs have better control and thus a quantitative drug release can be obtained. There are no prior art dendritic drugs that control release both sequentially and quantitatively like the dendritic drugs disclosed herein. The dendritic drugs are formed by incorporating multiple same type drug units or more than two different drug types into a dendritic cascade structure to form a dendrimer drug.
• METHOD OF PREPARING DENDRITIC DRUGS
  申请人：Chai Minghui

  公开号：US20160206746A1

  公开（公告）日：2016-07-21

  Synthetic design of drug-incorporated novel dendrimer structures for quantitatively controlled drug delivery. The dendritic drugs have better control and thus a quantitative drug release can be obtained. There are no prior art dendritic drugs that control release both sequentially and quantitatively like the dendritic drugs disclosed herein. The dendritic drugs are formed by incorporating multiple same type drug units or more than two different drug types into a dendritic cascade structure to form a dendrimer drug.
• US9603941B2
  申请人：——

  公开号：US9603941B2

  公开（公告）日：2017-03-28
• [EN] POLYMER CONJUGATED PROSTAGLANDIN ANALOGUES<br/>[FR] ANALOGUES DE PROSTAGLANDINE CONJUGUÉS À UN POLYMÈRE
  申请人：POLYACTIVA PTY LTD

  公开号：WO2012139164A1

  公开（公告）日：2012-10-18

  The present invention relates in general to polymer-drug conjugates. In particular, the invention relates to polymer-drug conjugates wherein the conjugated drugs are selected from prostaglandins and substituted prostaglandins, to a method of delivering such prostaglandin drugs to a subject, to a sustained drug delivery system comprising the polymer-drug conjugates, to a method of preparing the polymer-drug conjugates, and to an implant comprising the polymer-drug conjugates. The polymer-drug conjugates may be useful for delivering prostaglandins and substituted prostaglandins for the treatment of glaucoma.