Peptide bond formation by aminolysin-A catalysis: A simple approach to enzymatic synthesis of diverse short oligopeptides and biologically active puromycins
peptide bonds to give linear homo-oligopeptides, hetero-dipeptides, and cyclicdipeptides using cost-effective substrates in a one-pot reaction. Aminolysin-A can recognize several C-terminal-modified aminoacids, including the L- and D-forms, as acyl donors as well as free amines, including aminoacids and puromycin aminonucleoside, as acyl acceptors. The absence of aminoacid esters prevents the formation
Puromycin based inhibitors of aminopeptidases for the potential treatment of hematologic malignancies
作者:Rohit Singh、Jessica Williams、Robert Vince
DOI:10.1016/j.ejmech.2017.07.048
日期:2017.10
study of puromycin and its analogs for antibiotic properties. However, the peptidase inhibitory activity of related analogs has not been explored as extensively. Specifically, inhibiting aminopeptidases for achieving antitumor effect has been sparsely investigated. Herein, we address this challenge by reporting the synthesis of a series of analogs based on the structural template of puromycin. We also