癸基-Alpha-D-吡喃葡糖苷 | 29781-81-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 癸基-Alpha-D-吡喃葡糖苷
• 中文别名: 癸基-α-D-吡喃葡糖苷
• 英文名称: decyl α-D-glucopyranoside, anhydrous
• 英文别名: n-decyl-α-D-glucopyranoside；decyl α-D-glucopyranoside；decyl-α-glucopyranoside；n-decyl α-D-glucoside；n-decyl-α-D-glucoside；decyl α-D-glucoside；alpha-D-Glucopyranoside, decyl；(2S,3R,4S,5S,6R)-2-decoxy-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 29781-81-5
• 化学式: C₁₆H₃₂O₆
• 分子量: 320.426
• InChiKey: JDRSMPFHFNXQRB-LJIZCISZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38

反应信息

• 作为反应物：
  描述：

  癸基-Alpha-D-吡喃葡糖苷 在 lithium aluminium tetrahydride 、 四丁基溴化铵 、 对甲苯磺酸 、 sodium hydroxide 作用下， 以 甲醇 、 乙醚 、 氯仿 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 108.5h， 生成 caprylic acid-2,3-di-O-benzle-4,6-di-O-ethanamine-α-D-glucopyranoside
  参考文献：
  名称：

  A New Synthesis of Crown Ether-Based Methyl 4,6-Benzylidene-2,3-Di-O-Benzyl-a-D-Glucopyranosides Ethers as Anticancer Agents

  摘要：

  This study focuses on the synthesis and characterization of Aza and Thia Crown Ether-Based Methyl a-D-glucopyranosides using a phase transfer catalysis method. Characterization involved Fourier transform infrared, 1H NMR, and 13C NMR spectroscopy. The study also evaluated the anticancer potential of these compounds against PC3 (prostate cancer cells) and WRL68 (normal liver cells). Compound 12 exhibited a more significant effect on PC3 cells compared to compound 11. At the highest concentration (400 ?M), compound 12 demonstrated a mean inhibition of 95.72% in PC3 cells, while compound 11 showed a mean inhibition of 33.29% at the same concentration. Furthermore, the IC50 value for compound 12 in PC3 cells was 112.9 ?M, whereas compound 11 had an IC50 value of 24.38 ?M, indicating that compound 11 is less effective in inhibiting PC3 cell growth. These findings suggest that compound 12 may have greater potential as a therapeutic agent for prostate cancer.. KEYWORDS :Anticancer potential, Aza, Crown Ether-Based Methyl a-D-glucopyranosides, Cyclic peptides, Normal liver cells, Prostate cancer cells.

  DOI：

  10.59467/ijhc.2024.34.115
• 作为产物：
  描述：

  β-D-葡萄糖五乙酸酯 在 4 A molecular sieve 、 sodium methylate 、 四氯化锡 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 70.0h， 生成 癸基-Alpha-D-吡喃葡糖苷
  参考文献：
  名称：

  Konstantinovic; Predojevic; Mojsilovic, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 9, p. 796 - 801

  摘要：

  DOI：

文献信息

• [EN] PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS<br/>[FR] PEPTIDOMIMÉTIQUES POUR LE TRAITEMENT D'INFECTIONS PAR CORONAVIRUS ET PICORNAVIRUS
  申请人：UNIV EMORY

  公开号：WO2020247665A1

  公开（公告）日：2020-12-10

  Compounds, compositions and methods for preventing, treating or curing a coronavirus, picornavirus, and/or Hepeviridae virus infection in human subjects or other animal hosts. Specific viruses that can be treated include enteroviruses. In one embodiment, the compounds can be used to treat an infection with a severe acute respiratory syndrome virus, such as human coronavirus 229E, SARS, MERS, SARS-CoV-1 (OC43), and SARS-CoV- 2. In another embodiment, the methods are used to treat a patient co-infected with two or more of these viruses, or a combination of one or more of these viruses and norovirus.

  用于预防、治疗或治愈人类主体或其他动物宿主中的冠状病毒、小RNA病毒和/或肝炎病毒感染的化合物、组合物和方法。可治疗的特定病毒包括肠病毒。在一个实施例中，这些化合物可用于治疗严重急性呼吸综合征病毒感染，如人类冠状病毒229E、SARS、MERS、SARS-CoV-1（OC43）和SARS-CoV-2。在另一个实施例中，这些方法用于治疗患有两种或更多这些病毒的患者，或一种或多种这些病毒与诺如病毒的组合。
• Acylated Exendin-4 Compounds
  申请人：Lau Jesper

  公开号：US20090318353A1

  公开（公告）日：2009-12-24

  This invention provides new therapeutic peptides, i.e. new protracted Exendin-4 compounds, pharmaceutical compositions and the use of such.

  本发明提供了新的治疗性肽，即新的长效Exendin-4化合物、药物组合物及其用途。
• PREPARATION COMPRISING CHROMAN-2-ONE DERIVATIVES
  申请人：Mujica-Fernaud Teresa

  公开号：US20100291009A1

  公开（公告）日：2010-11-18

  The invention relates to preparations comprising at least one compound of the formula (I), where the substituents R 1 to R 4 have a meaning indicated in claim 1 , and salts and solvates thereof, and to the use thereof and selected compounds of the formula (I).

  该发明涉及包含至少一种式(I)化合物的制剂，其中取代基R1至R4具有权利要求1中指示的含义，以及其盐和溶剂合物，以及其用途和选择的式(I)化合物。
• POLYMER STABILIZER
  申请人：KIMURA Yoshikazu

  公开号：US20100179253A1

  公开（公告）日：2010-07-15

  A polymer stabilizer comprising the following alkoxy compound: the alkoxy compound: a compound obtained by alkoxylating at least one hydroxyl group contained in a compound of the following formula (1) containing one formyl group or carbonyl group and (n− 1 ) hydroxyl groups in the molecule with an alkyl group having 1 to 12 carbon atoms: C n H 2n O n (1) (wherein, n represents an integer of 3 or more).

  一种聚合物稳定剂，包含以下烷氧基化合物：所述烷氧基化合物是通过将含有以下通式（1）中的一个甲酰基或羰基以及分子中（n-1）个羟基的化合物中的至少一个羟基进行烷氧基化而得到的化合物，其中烷基团含有1至12个碳原子：CnH2nOn（1）（其中，n代表3或以上的整数）。
• Preparation of alkyl α- and β-d-glucopyranosides, thermotropic properties and X-ray analysis
  作者：Volker Adasch、Bettina Hoffmann、Wolfgang Milius、Gerhard Platz、Gundula Voss

  DOI：10.1016/s0008-6215(98)00302-4

  日期：1998.12

  Monohydrates of heptyl to decyl α- d -glucopyranosides as obtained from product mixtures of the Fischer glucosylation were crystallized from water at the Krafft point. The results of the single-crystal X-ray analysis of anhydrous α anomers and their monohydrates provide for a better understanding of crystal formation and stability of their hydrates. The preparation of alkyl β- d -glucopyranosides—without

  摘要从Fischer葡萄糖基化产物混合物中获得的庚基到癸基α-d-吡喃葡萄糖苷一水合物在克拉夫特点从水中结晶。无水α端基异构体及其一水合物的单晶X射线分析结果可更好地理解其水合物的晶体形成和稳定性。已经描述了烷基β-d-吡喃葡萄糖苷的制备-没有伴随形成副产物α-端基异构体。已经研究了α化合物及其一水合物和β-d-吡喃葡萄糖苷的热致性质。