6-O-(羟基膦酸)-alpha-D-吡喃葡萄糖钠盐 | 24404-57-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6-O-(羟基膦酸)-alpha-D-吡喃葡萄糖钠盐
• 英文名称: α-D-glucopyranosyl 6-phosphate monosodium salt
• 英文别名: alpha-D-Glucose-6-phosphate,monosodium salt；sodium;[(2R,3S,4S,5R,6S)-3,4,5,6-tetrahydroxyoxan-2-yl]methyl hydrogen phosphate
• CAS: 24404-57-7
• 化学式: C₆H₁₂O₉P*Na
• 分子量: 282.119
• InChiKey: ZALKNDISPIVVKC-WNFIKIDCSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -6.73
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  160
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  6-O-(羟基膦酸)-alpha-D-吡喃葡萄糖钠盐 在 ammonium hydroxide 、 selenium tetrachloride 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以62%的产率得到
  参考文献：
  名称：

  在二元溶剂系统中深入了解6-磷酸葡萄糖（G6P）与V（III），Ru（III），Au（III）和Se（IV）离子的络合

  摘要：

  葡萄糖-6-磷酸（G6P），其为配体（配制为LH - ）与V（III），钌（III），金（III）反应，和Se（IV）离子。获得的复合物的结构通过IR，1 H和13 C NMR，UV-Vis。，摩尔电导，元素和热技术进行表征。体外筛选了该复合物对两种革兰氏阳性和两种革兰氏阴性细菌的抗菌活性。此外，在体外评估了Au（III）配合物对两种不同的人类癌细胞系的细胞毒性通过基于MTT的单元技术。光谱和分析数据表明，G6P充当由磷酸基团的两个氧原子配位的双齿配体。这将形成具有Au（III）和Se（IV）离子的方形平面几何形状以及具有V（III）和Ru（III）离子的八面体几何形状。有趣的是，Au（III）复合物对HepG2和MCF-7细胞系的细胞毒作用分别比游离配体大80倍和45倍。

  DOI：

  10.1016/j.molliq.2019.111999

文献信息

• Fluorescent molecular sensor for targeting changes in protein surfaces, and methods of use thereof
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US10557852B2

  公开（公告）日：2020-02-11

  This invention is directed to monomolecular sensors, comprising a selective binder, a non-selective binder and a fluorophore, which can track changes that occur on the surface of labeled proteins. This invention is further directed to the use of such sensors for identifying binding partners of specific proteins. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins.

  本发明涉及单分子传感器，它由选择性粘合剂、非选择性粘合剂和荧光团组成，可跟踪标记蛋白质表面发生的变化。本发明还涉及利用这种传感器识别特定蛋白质的结合伙伴。本发明进一步涉及 His 标记结合化合物及其在制备基因靶向可检测分子和传感器中的用途，这些分子和传感器可以特异性地结合标记蛋白质。
• FLUORESCENT MOLECULAR SENSOR FOR TARGETING CHANGES IN PROTEIN SURFACES, AND METHODS OF USE THEREOF
  申请人：Yeda Research and Development Co., Ltd.

  公开号：EP3137898A2

  公开（公告）日：2017-03-08
• UNIVERSAL HISTIDINE-TAG BINDING COMPOUNDS AND METHODS OF USE THEREOF AS FLUORESCENT PROBES AND SENSORS
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US20200256857A1

  公开（公告）日：2020-08-13

  This invention is directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further provides a system comprising recombinant cells decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying the cells and methods for using thereof.
• QUINOLINE BASED CYANINE DYE TURN-ON FLUORESCENT PROBES AND METHODS OF USE THEREOF
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US20210156867A1

  公开（公告）日：2021-05-27

  This invention is directed to a turn-on fluorescent probe, wherein said probe comprises a quinoline based cyanine dye derivative (QBC) and a specific protein binder covalently attached thereto directly or via a linker. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further describes methods for using these turn-on probes and compounds for detecting and labelling a wide range of proteins in their native environment.
• [EN] FLUORESCENT MOLECULAR SENSOR FOR TARGETING CHANGES IN PROTEIN SURFACES, AND METHODS OF USE THEREOF<br/>[FR] CAPTEUR MOLÉCULAIRE FLUORESCENT PERMETTANT DE CIBLER DES MODIFICATIONS AFFECTANT LA SURFACE DE PROTÉINES ET SES PROCÉDÉS D'UTILISATION
  申请人：YEDA RES & DEV

  公开号：WO2015166491A2

  公开（公告）日：2015-11-05

  This invention is directed to monomolecular sensors, comprising a selective binder, a non-selective binder and a fluorophore, which can track changes that occur on the surface of labeled proteins. This invention is further directed to the use of such sensors for identifying binding partners of specific proteins. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins.