9,10-dihydro-acridine-9-carboxylic acid | 197156-36-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9,10-dihydro-acridine-9-carboxylic acid
• 英文别名: 9,10-Dihydro-acridin-9-carbonsaeure；9,10-Dihydroacridine-9-carboxylic acid
• CAS: 197156-36-8
• 化学式: C₁₄H₁₁NO₂
• 分子量: 225.247
• InChiKey: XQZQGXKLCXJLKB-UHFFFAOYSA-N

物化性质

• 熔点：
  229 °C (decomp)
• 沸点：
  429.2±44.0 °C(Predicted)
• 密度：
  1.291±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  9,10-dihydro-acridine-9-carboxylic acid 在 五氯化磷 、 Petroleum ether 作用下， 生成 10-acetyl-9,10-dihydro-acridine-9-carbonyl chloride
  参考文献：
  名称：

  Carbinolamines Derived from N-Acetyl-9-ι-bromoacetyl-9,10-dihydroacridine. Rearrangement of the Halomethyl Ketone¹

  摘要：

  DOI：

  10.1021/jo01117a019
• 作为产物：
  描述：

  9,10-二氢吖啶 在 乙醚 、 lithium 作用下， 生成 9,10-dihydro-acridine-9-carboxylic acid
  参考文献：
  名称：

  Bergmann; Fujise, Justus Liebigs Annalen der Chemie, 1930, vol. 483, p. 65,76

  摘要：

  DOI：

文献信息

• Ultra-Sensitive Chemiluminescent Substrates for Enzymes and Their Conjugates
  申请人：Giri Pal Brij

  公开号：US20070225498A1

  公开（公告）日：2007-09-27

  New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridanebased compounds and (1,2)-dioxetanes. Among the new acridanebased compounds are water-soluble acridanes, enhancer coupled acridanes, bis and trisacridanes as well as acridane-(1,2)-dioxetanes. Among the new (1,2)-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The (1,2)-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent. An aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.

  新的化学发光化合物，稳定在水性缓冲液中，用于生物分析包括基于吖啶的化合物和(1,2)-二氧杂环辛烷。在新的基于吖啶的化合物中包括水溶性吖啶、增强剂偶联的吖啶、双吖啶和三吖啶以及吖啶-(1,2)-二氧杂环辛烷。在新的(1,2)-二氧杂环辛烷中包括含电子亏损基团的二氧杂环辛烷和连接的双-1,2-二氧杂环辛烷。这些(1,2)-二氧杂环辛烷可作为各种酶的底物。吖啶可以与氧化剂混合。水性缓冲液和可选的稳定剂可形成用于分析的底物或试剂配方，用于分析，包括HRP等。
• Processes and synthetic intermediates for preparing N-arylacridancarboxylic acid derivatives
  申请人：——

  公开号：US20010031869A1

  公开（公告）日：2001-10-18

  Synthetic processes and intermediates are disclosed for the preparation of N-arylacridancarboxylic acid derivatives. The derivatives are esters, thioesters, amides and sulfonimides. A key feature of the processes is the preparation of N-aryl substituted intermendiates by formation of a bond between the nitrogen atom of the acridan ring and a carbon atom of another aromatic or heteroaromatic ring compound. The arylation reaction is catalyzed by a palladium catalyst. The N-arylacridancarboxylic acid derivatives are useful in methods for producing light and in assays for peroxidase enzymes and enzyme inhibitors and in assays employing enzyme-labeled specific binding pairs.

  揭示了用于制备N-芳基吖啶并羧酸衍生物的合成过程和中间体。这些衍生物是酯、硫酯、酰胺和磺酰亚胺。该过程的一个关键特征是通过在吖啶环的氮原子和另一芳香或杂芳环化合物的碳原子之间形成键来制备N-芳基取代的中间体。芳基化反应由钯催化剂催化。N-芳基吖啶并羧酸衍生物在制备光和过氧化物酶以及酶抑制剂的方法中是有用的，并在采用酶标记的特异结合对的测定中也是有用的。
• ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES
  申请人：Giri Brij Pal

  公开号：US20150031889A1

  公开（公告）日：2015-01-29

  New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent, an aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.

  新的化学发光化合物，稳定在水溶液缓冲液中，用于生物测定，包括基于蒽醌的化合物和1,2-二氧杂环烷。新的基于蒽醌的化合物包括水溶性蒽醌，增强剂偶联蒽醌，双蒽醌和三蒽醌以及蒽醌-1,2-二氧杂环烷。新的1,2-二氧杂环烷包括含电子亏损基团的二氧杂环烷和连接的双1,2-二氧杂环烷。1,2-二氧杂环烷可用作各种酶的底物。蒽醌可以与氧化剂、水溶液缓冲液和必要时稳定剂混合，形成用于测定HRP等的底物或试剂配方。
• NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES
  申请人：Giri Brij Pal

  公开号：US20140073771A1

  公开（公告）日：2014-03-13

  New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent. an aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.

  新的化学发光化合物，可以在水性缓冲液中稳定使用，用于生物测定，包括基于蒽醌的化合物和1,2-二氧杂环烷。其中，新的基于蒽醌的化合物包括水溶性蒽醌、增强剂偶联蒽醌、双蒽醌和三蒽醌以及蒽醌-1,2-二氧杂环烷。新的1,2-二氧杂环烷包括含电子亏损基团的二氧杂环烷和连接的双1,2-二氧杂环烷。1,2-二氧杂环烷可用作各种酶的底物。蒽醌可以与氧化剂、水性缓冲液以及可选的稳定剂混合，形成用于测定HRP等的底物或试剂配方。
• Stabilised imide graft of ethylene copolymeric additives for lubricants, process for their preparation, process for stabilising additive concentrates for lubricants based on the imide graft ethylene copolymer and lubricating oil compositions comprising the stabilised additive
  申请人：EXXON RESEARCH AND ENGINEERING COMPANY

  公开号：EP0000648A1

  公开（公告）日：1979-02-07

  Oil-soluble, derivatized ethylene copolymers used as additives for lubricants, derived from about 2 to 98 weight % ethylene, and one or more C, to C28 alpha-olefins, e.g. propylene, which are grafted in the presence of a high-temperature decomposable free-radical initiator, with an ethylenically-unsaturated dicarboxylic acid material and thereafter reacted with a polyamine having at least two primary amine groups, e.g. an alkylene polyamine such as diethylene triamine, to form carboxyl-grafted polymeric imide derivatives are subsequently reacted with an anhydride of a C1-C30 hydrocarbyl-substituted acid, preferably acetic anhydride, to yield an oil-soluble stable amide of said polyamine. The oil solutions of said amide derivative are characterized by minimal viscosity change over an extended period of time.

  用于润滑油添加剂的油溶性衍生化乙烯共聚物，由重量百分比约为 2 至 98% 的乙烯和一种或多种 C 至 C28 α-烯烃（如丙烯）衍生而成，在高温可分解自由基引发剂存在下与乙烯不饱和二羧酸材料接枝，然后与具有至少两个伯胺基团的聚胺（如二乙三胺）反应，形成羧基接枝聚合酰亚胺衍生物。g.烷基多胺（如二乙烯三胺）反应，形成羧基接枝的聚合酰亚胺衍生物，然后与 C1-C30 烃基取代酸的酸酐（最好是乙酸酐）反应，得到所述多胺的油溶性稳定酰胺。所述酰胺衍生物油溶液的特点是在较长时间内粘度变化极小。