[3-(1H-Indol-3-yl)-propyl]-[2-(naphthalen-1-yloxy)-ethyl]amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [3-(1H-Indol-3-yl)-propyl]-[2-(naphthalen-1-yloxy)-ethyl]amine
• 英文别名: [3-(1H-Indol-3-yl)-propyl]-[2-(naphthalen-1-yloxy)-ethyl]-amine；3-(1H-indol-3-yl)-N-(2-naphthalen-1-yloxyethyl)propan-1-amine
• 化学式: C₂₃H₂₄N₂O
• 分子量: 344.456
• InChiKey: LTMYWNLLSXEOLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-吲哚丙酸 在 lithium aluminium tetrahydride 、 三乙胺 、 N,N'-羰基二咪唑 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 19.0h， 生成 [3-(1H-Indol-3-yl)-propyl]-[2-(naphthalen-1-yloxy)-ethyl]amine
  参考文献：
  名称：

  Studies toward the Discovery of the Next Generation of Antidepressants. 3. Dual 5-HT_1A and Serotonin Transporter Affinity within a Class of N-Aryloxyethylindolylalkylamines

  摘要：

  N-Aryloxylethylindolealkylamines (5) having dual 5-HT transporter and 5-HT1A affinity are described. These compounds represent truncated analogues of our previously reported piperidinyl derivatives (3). Compounds in this investigation were found to have more similar affinities and functional activities for the 5-HT1A receptor and 5-HT transporter. Though 5-HT1A antagonism is not consistently observed throughout series 5, several molecular features were found to be essential to obtain high and balanced activities. The proper placement of a heteroatom in the aryl ring and the length of the linkage used to tether the indole moiety had significant influence on 5-HT1A and 5-HT transporter affinities. Introduction of a halogen into the aryl ring usually lowered intrinsic activity and in some cases led to full 5-HT1A antagonists. Compounds 33 and 34 were observed to be full 5-HT1A antagonists with K-i values of approximately 30 nM for the 5-HT1A receptor and K-i values of 5 and 0.5 nM for the 5-HT transporter, respectively. Unfortunately, similar to our previous series (3), compounds in this report also had high affinity for the alpha(1) receptor.

  DOI：

  10.1021/jm0304010

文献信息

• N-aryloxyethyl-indoly-alkylamines for the treatment of depression
  申请人：American Home Products Corp.

  公开号：US06121307A1

  公开（公告）日：2000-09-19

  Compounds useful for alleviating symptoms of depression are provided which have the following formula: wherein: R.sub.1 is hydrogen, lower alkyl or aryl; R.sub.2 is hydrogen, lower alkyl, phenyl or substituted phenyl; X and Y are each, independently, hydrogen, lower alkyl, lower alkoxy, or halogen, or together combine with the carbon atoms to which they are attached to complete a pyranyl, dihydrofuranyl, furanyl, or dioxanyl, group; Z is hydrogen, halogen or lower alkoxy; with the proviso that when X, Y or Z represent lower alkoxy, they are not present at the ortho position; W is hydrogen, halogen, lower alkyl, cyano or a trifluoromethyl group; and n is 2-5; or pharmaceutically acceptable salts thereof.

  提供了用于缓解抑郁症症状的化合物，其具有以下结构式：其中：R.sub.1为氢、低碳基或芳基；R.sub.2为氢、低碳基、苯基或取代苯基；X和Y分别独立地为氢、低碳基、低烷氧基或卤素，或者与它们连接的碳原子结合在一起形成吡喃基、二氢呋喃基、呋喃基或二氧杂环基；Z为氢、卤素或低烷氧基；但当X、Y或Z代表低烷氧基时，它们不位于邻位；W为氢、卤素、低碳基、氰基或三氟甲基基团；n为2-5；或其药用盐。
• N-arloxyethyl-alkylamines for the treatment of depression
  申请人：American Home Products Corp

  公开号：US06291683B1

  公开（公告）日：2001-09-18

  Compounds useful for alleviating symptoms of depression are provided which have the following formula: wherein: R1 is hydrogen, lower alkyl or aryl; R2 is hydrogen, lower alkyl, phenyl or substituted phenyl; X and Y are each, independently, hydrogen, lower alkyl, lower alkoxy, or halogen, or together combine with the carbon atoms to which they are attached to complete a cyclopentyl, cyclohexyl, phenyl, pyrrolyl, pyranyl, pyridinyl, dihydrofuranyl, furanyl, dioxanyl, oxazolyl or isoxazolyl group; Z is hydrogen, halogen or lower alkoxy; with the proviso that when X, Y or Z represent lower alkoxy, they are not present at the ortho position; W is hydrogen, halogen, lower alkyl, cyano or a trifluoromethyl group; and n is 2-5; or pharmaceutically acceptable salts thereof.

  提供了用于缓解抑郁症状的化合物，其具有以下结构式：其中：R1为氢、低级烷基或芳基；R2为氢、低级烷基、苯基或取代苯基；X和Y各自独立地为氢、低级烷基、低级烷氧基或卤素，或者结合它们所连接的碳原子以完成环戊基、环己基、苯基、吡咯基、吡喃基、吡啶基、二氢呋喃基、呋喃基、二氧杂环己基、噁唑基或异噁唑基；Z为氢、卤素或低级烷氧基；但当X、Y或Z表示低级烷氧基时，它们不出现在邻位；W为氢、卤素、低级烷基、氰基或三氟甲基基团；n为2-5；或其药学上可接受的盐。
• N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS)
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP1070050A1

  公开（公告）日：2001-01-24
• US6121307A
  申请人：——

  公开号：US6121307A

  公开（公告）日：2000-09-19
• US6291683B1
  申请人：——

  公开号：US6291683B1

  公开（公告）日：2001-09-18