4-[(4,6-dichloro-1,3,5-triazin-2-yl)oxy]-benzoic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[(4,6-dichloro-1,3,5-triazin-2-yl)oxy]-benzoic acid
• 英文别名: 4-[(4,6-Dichloro-1,3,5-triazin-2-yl)oxy]benzoic acid；4-[(4,6-dichloro-1,3,5-triazin-2-yl)oxy]benzoic acid
• 化学式: C₁₀H₅Cl₂N₃O₃
• 分子量: 286.074
• InChiKey: LBNXREXRJLSMIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  85.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-[(4,6-dichloro-1,3,5-triazin-2-yl)oxy]-benzoic acid 、 聚甘氨酸 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 0.33h， 以76%的产率得到4-[[4,6-Bis(carboxymethylamino)-1,3,5-triazin-2-yl]oxy]benzoic acid
  参考文献：
  名称：

  Facile and efficient synthesis of C2-symmetrical 1,3,5-triazine polycarboxylate ligands under microwave irradiation

  摘要：

  A rapid and efficient method for preparation of C-2-symmetrical 1,3,5-triazine polycarboxylate ligands was developed. The reactions included either selective mono- or di-substitution of 2,4,6-trichloro-1,3,5-triazine with various nucleophiles containing carboxyl group(s), followed by nucleophilic displacement of the remained chloride(s) in aqueous media under microwave irradiation. Novel C-2-symmetrical tripodal ligands were afforded in good yields and purities under short reaction time with simple work-up, which are potentially useful as structural directing units in metal-organic frameworks. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.06.127
• 作为产物：
  描述：

  三聚氯氰 、 对羟基苯甲酸 在 sodium hydroxide 作用下， 以 水 、 丙酮 为溶剂， 反应 3.0h， 以82%的产率得到4-[(4,6-dichloro-1,3,5-triazin-2-yl)oxy]-benzoic acid
  参考文献：
  名称：

  Facile and efficient synthesis of C2-symmetrical 1,3,5-triazine polycarboxylate ligands under microwave irradiation

  摘要：

  A rapid and efficient method for preparation of C-2-symmetrical 1,3,5-triazine polycarboxylate ligands was developed. The reactions included either selective mono- or di-substitution of 2,4,6-trichloro-1,3,5-triazine with various nucleophiles containing carboxyl group(s), followed by nucleophilic displacement of the remained chloride(s) in aqueous media under microwave irradiation. Novel C-2-symmetrical tripodal ligands were afforded in good yields and purities under short reaction time with simple work-up, which are potentially useful as structural directing units in metal-organic frameworks. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.06.127

文献信息

• Facile and efficient synthesis of C2-symmetrical 1,3,5-triazine polycarboxylate ligands under microwave irradiation
  作者：Watcharee Funfuenha、Wong Phakhodee、Mookda Pattarawarapan

  DOI：10.1016/j.tet.2014.06.127

  日期：2014.9

  A rapid and efficient method for preparation of C-2-symmetrical 1,3,5-triazine polycarboxylate ligands was developed. The reactions included either selective mono- or di-substitution of 2,4,6-trichloro-1,3,5-triazine with various nucleophiles containing carboxyl group(s), followed by nucleophilic displacement of the remained chloride(s) in aqueous media under microwave irradiation. Novel C-2-symmetrical tripodal ligands were afforded in good yields and purities under short reaction time with simple work-up, which are potentially useful as structural directing units in metal-organic frameworks. (C) 2014 Elsevier Ltd. All rights reserved.