1-乙基-3-甲基咪唑氨基乙酸鎓盐 | 766537-74-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1-乙基-3-甲基咪唑氨基乙酸鎓盐
• 英文名称: 1-ethyl-3-methylimidazolium glycinate
• 英文别名: 1-Ethyl-3-methylimidazolium aminoacetate；2-aminoacetate;1-ethyl-3-methylimidazol-3-ium
• CAS: 766537-74-0
• 化学式: C₂H₄NO₂*C₆H₁₁N₂
• 分子量: 185.226
• InChiKey: DVTRRYWFKKZCIE-UHFFFAOYSA-M

物化性质

• 密度：
  1.1651 g/cm3(Temp: 15.00 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.97
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  75
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933290090
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  存于室温下，请密封并保持干燥。

反应信息

• 作为反应物：
  描述：

  甘氨酸甲酯盐酸盐 、 1-乙基-3-甲基咪唑氨基乙酸鎓盐 在 磷酸 作用下， 反应 3.0h， 以50%的产率得到双甘肽
  参考文献：
  名称：

  使用氨基酸离子液体的无偶联试剂的二肽和三肽合成

  摘要：

  已经开发了合成二肽的通用方法，该方法不需要任何偶联剂。该方法基于容易获得的氨基酸甲酯的HCl盐与四丁基phosph氨基酸离子液体的反应。用AcOH逐步处理的分离过程很容易进行。该方法还扩展到IMREG-1中也存在的三肽酪氨酰甘氨酰甘氨酸的合成。

  DOI：

  10.1002/chem.201501783
• 作为产物：
  描述：

  氯化 1-乙基-3-甲基咪唑 在 SUPELCO AMBERLITE IRN-78 作用下， 以 水 为溶剂， 反应 12.0h， 生成 1-乙基-3-甲基咪唑氨基乙酸鎓盐
  参考文献：
  名称：

  Density, Viscosity, and Refractive Index of Ionic Liquid Mixtures Containing Cyano and Amino Acid-Based Anions

  摘要：

  In this work, mixtures of five ionic liquids (ILs) based on a common cation, 1-ethyl-3-methylimidazolium ([C(2)mim](+)), and amino acid anions, namely glycinate ([Gly](-)), l-alaninate ([l-Ala](-)), taurinate ([Tau](-)), L-serinate ([L-Ser](-)), and L-prolinate ([L-Pro](-)) with 1-ethyl-3-methylimidazolium tricyanomethane, [C(2)mim][C(CN)(3)], were prepared. The thermophysical properties, namely density, viscosity, and refractive index, of the neat ILs and their mixtures were measured in the temperature range of T = (293.15 up to 353.15) K. The thermal expansion coefficients were calculated for the neat ILs and were considered to be independent of temperature in the working temperature range. Overall, experimental density, viscosity, and refractive index data of the neat AAILs were in a good agreement with those reported in literature. A dramatic decrease in the viscosity was observed for the IL mixtures as the [C(2)mim][C(CN)(3)] content increased. The obtained results indicate that mixing [C(2)mim][C(CN)(3)] with amino acid-based ILs is a potential mean to further increase flexibility and the fine-tune capacity of the physical and chemical properties of amino acid-based ILs.

  DOI：

  10.1021/acs.jced.5b00242
• 作为试剂：
  描述：

  2-环己烯-1-酮 、 苯胺 在 1-乙基-3-甲基咪唑氨基乙酸鎓盐 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以35%的产率得到3-phenylamino-cyclohexan-1-one
  参考文献：
  名称：

  Ionic amino acids: Application as organocatalysts in the aza-Michael reaction

  摘要：

  The ethyl methyl imidazolium salts of amino acids, [emiml[AA], have been used as catalysts in the aza-Michael reaction. Furthermore, when chiral amino acids were used, a stereoselective reaction was achieved. The mechanism of the transformation was verified by the detection of a key intermediate by electrospray ionization mass spectroscopy (ESI-MS). (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2012.11.012

文献信息

• Amino acid ionic liquid-based facilitated transport membranes for CO2 separation
  作者：Shohei Kasahara、Eiji Kamio、Toru Ishigami、Hideto Matsuyama

  DOI：10.1039/c2cc17380h

  日期：——

  Supported liquid membranes incorporating amino acid ionic liquids remarkably facilitate CO2 permeation under dry and low humid conditions.

  含有氨基酸离子液体的支撑液体膜在干燥和低湿条件下显著促进了二氧化碳的渗透。
• Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs): Nanostructure of the Glassy State Studied by Electron Paramagnetic Resonance Spectroscopy
  作者：Olga D. Bakulina、Mikhail Yu. Ivanov、Dmitriy V. Alimov、Sergey A. Prikhod’ko、Nicolay Yu. Adonin、Matvey V. Fedin

  DOI：10.3390/molecules27165117

  日期：——

  for pharmaceutical applications. Although nanostructuring phenomena were actively investigated in common ILs, their studies in API-ILs are scarce so far. In this work, using the complex methodology of Electron Paramagnetic Resonance (EPR) and dissolved spin probes, we investigate nanostructuring phenomena in a series of API-ILs: [Cnmim][Ibu], [Cnmim][Gly], and [Cnmim][Sal] with n = 2, 4, and 6, respectively

  活性药物成分离子液体 (API-IL) 作为一类特殊的离子液体，具有不寻常的理化特性以及同时具有药物应用潜力的特性，引起了越来越多的关注。尽管纳米结构现象在普通离子液体中得到了积极的研究，但迄今为止在 API-IL 中的研究还很少。在这项工作中，我们使用电子顺磁共振 (EPR) 和溶解自旋探针的复杂方法，研究了一系列 API-IL 中的纳米结构现象：[C n mim][Ibu]、[C n mim][Gly]、和 [C n mim][Sal]，其中n分别为 2、4 和 6。我们揭示了 API-IL 和常见 IL 的相似趋势，以及所研究的 API-IL 固有的特性。 [C n mim][Ibu] 观察到的异常行为归因于 [Ibu] -阴离子中存在非极性片段，与常见的 IL 相比，这导致在自由基周围形成更复杂的纳米结构。了解这种自组织分子结构形成的一般趋势对于应用 API-IL 具有根本意义和重要性。
• SILICONE ADHESIVE COMPOSITION AND ADHESIVE TAPE
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP3290489A1

  公开（公告）日：2018-03-07

  One of the purposes of the present invention is to provide a silicone adhesive composition which provides an adhesive layer having an excellent antistatic property and which has an excellent bond strength to a tape substrate and, therefore, when an adhesive tape or film having the adhesive layer is peeled from a tape-stuck body, less residual adhesive occurs on the tape-stuck body. The other purpose of the present invention is to provide a silicone adhesive composition which cures well by heating for a short time, particularly for less than 5 minutes, to provide an adhesive layer having an excellent antistatic property. The present invention first provides a silicone adhesive composition comprising (A) an addition reaction-curable silicone, (B1) a compound having at least two unsaturated hydrocarbon groups and two (poly)oxyalkylene residues in one molecule, and (C) an ionic liquid containing no lithium. The present invention secondly provides a silicone adhesive composition comprising (A) an addition reaction-curable silicone, (B) a compound having at least one unsaturated hydrocarbon group and at least one (poly) oxyalkylene residue in one molecule, (C) an ionic liquid containg no lithium and (e) a platinum group metal catalyst which is not a complex with a compound having an unsaturated hydrocarbon bond.

  本发明的目的之一是提供一种硅酮粘合剂组合物，该组合物提供的粘合剂层具有极佳的抗静电性能，并且与胶带基材具有极佳的粘合强度，因此，当具有该粘合剂层的胶带或薄膜从胶带粘贴体上剥离时，胶带粘贴体上的残留粘合剂较少。本发明的另一个目的是提供一种硅酮粘合剂组合物，该组合物通过短时间，特别是少于 5 分钟的加热就能很好地固化，从而提供具有优异抗静电性能的粘合层。本发明首先提供了一种有机硅粘合剂组合物，该组合物包括（A）加成反应固化的有机硅，（B1）在一个分子中具有至少两个不饱和烃基和两个（聚）氧烷基残基的化合物，以及（C）不含锂的离子液体。本发明其次提供了一种有机硅粘合剂组合物，该组合物包含 (A) 加成反应固化有机硅，(B) 在一个分子中具有至少一个不饱和烃基和至少一个（聚）氧烷基残基的化合物，(C) 不含锂的离子液体，以及 (e) 不与具有不饱和烃键的化合物形成络合物的铂族金属催化剂。
• Process for the production of a hybrid structure consisting of coupled silk fibroin microfibers and nanofibers, hybrid structure thus obtained and its use as implantable medical device
  申请人：SILK BIOMATERIALS S.R.L.

  公开号：US10758641B2

  公开（公告）日：2020-09-01

  A method is described for the production of hybrid structures formed by the coupling of nanofibrous parts and microfibrous parts made with silk fibroin, possibly hierarchically organized into complex structures comprising more than two of said parts; these hybrid structures are used as implantable biomedical devices with tailored biological, geometrical and structural features, such that they can be adapted to different application requirements in the field of regenerative medicine.

  本文介绍了一种生产混合结构的方法，这种混合结构由纳米纤维部分和丝纤维素微纤维部分耦合而成，可能分层组织成由两个以上所述部分组成的复杂结构；这些混合结构可用作具有定制生物、几何和结构特征的可植入生物医学装置，从而使其能够适应再生医学领域的不同应用要求。
• Liquid protein formulations containing 4-(3-butyl-1-imidazolio)-1-butane sulfonate (BIM)
  申请人：Eagle Biologics, Inc.

  公开号：US10821183B2

  公开（公告）日：2020-11-03

  Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous or intramuscular injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and viscosity-reducing ionic liquids.

  目前已开发出浓缩、低粘度、低容量的液体蛋白质药物制剂。这些制剂可以通过皮下注射或肌肉注射快速方便地给药，而不需要长时间的静脉注射。这些制剂包括低分子量和/或高分子量蛋白质（如 mAbs）以及降粘离子液体。