Gly-tetra-n-butyl-ammonium salt | 113790-35-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Gly-tetra-n-butyl-ammonium salt
• 英文别名: glycine tetrabutylammonium salt；tetra-nbutylammonium glycinate；tetrabutylammonium glycinate；tetrabutylammonium glycin；2-aminoacetate;tetrabutylazanium
• CAS: 113790-35-5
• 化学式: C₂H₄NO₂*C₁₆H₃₆N
• 分子量: 316.528
• InChiKey: YIUHWLIUHXPXEI-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  66.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甘氨酸甲酯盐酸盐 、 Gly-tetra-n-butyl-ammonium salt 在 磷酸 作用下， 反应 3.0h， 以39%的产率得到双甘肽
  参考文献：
  名称：

  使用氨基酸离子液体的无偶联试剂的二肽和三肽合成

  摘要：

  已经开发了合成二肽的通用方法，该方法不需要任何偶联剂。该方法基于容易获得的氨基酸甲酯的HCl盐与四丁基phosph氨基酸离子液体的反应。用AcOH逐步处理的分离过程很容易进行。该方法还扩展到IMREG-1中也存在的三肽酪氨酰甘氨酰甘氨酸的合成。

  DOI：

  10.1002/chem.201501783
• 作为产物：
  描述：

  四丁基氢氧化铵 、 聚甘氨酸 以 甲醇 、 水 为溶剂， 反应 1.0h， 生成 Gly-tetra-n-butyl-ammonium salt
  参考文献：
  名称：

  使用Kaiser肟树脂制备保护肽段的实用方法

  摘要：

  可以使用侧链保护的氨基酸的四正丁基铵盐从Kaiser肟树脂上裂解树脂结合的肽，以直接提供α-氨基保护（Boc），侧链保护的肽。提供了完整的实验细节。可以纯化保护的肽片段并将其用于片段偶联合成策略。

  DOI：

  10.1016/s0040-4039(01)80541-4
• 作为试剂：
  描述：

  2-甲基吲哚 、 水杨醛 、 丙二腈 在 Gly-tetra-n-butyl-ammonium salt 作用下， 以 neat (no solvent) 为溶剂， 反应 2.0h， 以94%的产率得到2-amino-4-(2-methyl-1H-indol-3-yl)-4H-chromene-3-carbonitrile
  参考文献：
  名称：

  [TBA][Gly] ionic liquid promoted multi-component synthesis of 3-substituted indoles and indolyl-4H-chromenes

  摘要：

  Tetrabutylammonium glycinate [TBA][Gly] ionic liquid was found to be an efficient recyclable and biodegradable organocatalyst for selective synthesis of 3-substituted indoles and indolyl-4H-chromenes. The reaction between substituted aliphatic/aromatic aldehydes, malononitrile, and indoles in the presence of [TBA][Gly] IL at 60 degrees C under solvent free conditions afforded 3-substituted indoles in excellent yields. Indolyl-4H-chromenes were achieved in excellent yields by replacing the benzaldehydes with salicylaldehyde under optimized reaction conditions. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.02.058

文献信息

• Chiral discrimination of α-amino acids with a C₂-symmetric homoditopic receptor
  作者：Sunderraman Sambasivan、Dae-sik Kim、Kyo Han Ahn

  DOI：10.1039/b919957h

  日期：——

  Chiral discrimination of α-amino acids has been realized by a C2-symmetric homoditopic receptor, which is based on a binaphthyl chiral skeleton with 2,2′diisopropoxy substituents and a common binding side arm, (o-carboxamido)-trifluoroacetophenone moiety, in the 3,3′-positions, which recognizes α-amino acids as their amino carboxylate forms through formation of stabilized adducts.

  通过一种C2对称的同位受体实现了对α-氨基酸的手性分辨，该受体基于具有2,2'-二异丙氧基取代基和共通结合侧臂（o-氨基酰基）-三氟乙酰苯酮部分的双萘手性骨架，在3,3'-位置，能够以其氨基羧酸盐形式识别α-氨基酸，通过形成稳定的加合物。
• Synthesis of SB-214857 using Copper Catalysed Amination of Arylbromides with l-Aspartic Acid
  作者：Jean-Baptiste Clement、Jerome F. Hayes、Helen M. Sheldrake、Peter W. Sheldrake、Andrew S. Wells

  DOI：10.1055/s-2001-16780

  日期：——

  An efficient synthesis of a 1,4-benzodiazepine was accomplished using copper catalysed amination of an arylbromide with the soluble bis-tetrabutylammonium salt of l-aspartic acid as a key step.

  通过铜催化芳基溴化物与可溶性双四丁基铵盐的氨基化反应，实现了1,4-苯并二氮杂卓的高效合成，其中l-天冬氨酸是关键步骤。
• Fast-curing benzoxazine compounds
  申请人：Henkel AG & Co. KGaA

  公开号：EP2314579A1

  公开（公告）日：2011-04-27

  The present invention relates to a specific benzoxazine compound A of formula (I), wherein q is an integer from 1 to 4, M is hydrogen, a monovalent cation, or an equivalent of a polyvalent cation, Z is selected from the group consisting of a direct bond (when q is 2), hydrogen (when q is 1), alkyl (when q is 1), alkylene (when q is 2 to 4), carbonyl (when q is 2), oxygen (when q is 2), thiol (when q is 1), sulfur (when q is 2), sulfoxide (when q is 2), and sulfone (when q is 2), R6 is a linear or branched divalent alkylene group, comprising 1 to 15 carbon atoms, which may be interrupted by one or more heteroatom(s), selected from oxygen, nitrogen and sulfur, and R5 is selected from hydrogen, halogen, alkyl, alkenyl or R5 is a divalent residue creating a naphthoxazine residue out of the benzoxazine structure. A further object of the present invention is a polymerizable composition and a cured product obtained from the polymerizable composition, wherein said composition comprises at least one benzoxazine compound A and at least one benzoxazine compound B, which is different from benzoxazine compound A.

  本发明涉及一种特定的苯并噁啉化合物A，其化学式为(I)，其中q为1到4的整数，M为氢、一价阳离子或多价阳离子的等价物，Z选自以下组成的一组：直接键（当q为2时）、氢（当q为1时）、烷基（当q为1时）、烷烃（当q为2到4时）、酰基（当q为2时）、氧（当q为2时）、硫醇（当q为1时）、硫（当q为2时）、亚砜（当q为2时）和砜（当q为2时），R6为线性或支链的二价烷基烷基，包括1到15个碳原子，可以被一个或多个氧、氮和硫等杂原子打断，R5选自氢、卤素、烷基、烯基或R5是一个二价残基，使苯并噁啉结构变为萘噁啉残基。本发明的另一个目的是一种可聚合的组合物和从该可聚合组合物获得的固化产物，其中所述组合物至少包括一种苯并噁啉化合物A和至少一种与苯并噁啉化合物A不同的苯并噁啉化合物B。
• Functional benzoxazines containing ammonium salt of carboxylic acid: Synthesis and highly activated thermally induced ring-opening polymerization
  作者：Atsushi Sudo、Ryoichi Kudoh、Takeshi Endo

  DOI：10.1002/pola.24594

  日期：2011.4.1

  1,3‐Benzoxazine monomers having ammonium salt of carboxylic acid have been developed. These 1,3‐benzoxazines 1a and 1b were easily synthesized from the corresponding tetrabutylammonium salts of glycine and β‐alanine, respectively. The glycine‐derived benzoxazine 1a exhibited remarkably high reactivity, which allowed its thermally induced ring‐opening polymerization in bulk at 100 °C, at which N‐methyl‐1

  已开发出具有羧酸铵盐的1,3-苯并恶嗪单体。这些1,3-苯并恶嗪1a和1b分别由甘氨酸和β-丙氨酸的相应四丁基铵盐轻松合成。甘氨酸衍生的苯并恶嗪1a表现出极高的反应活性，使其在100°C时发生热诱导的开环聚合反应，在该温度下N-甲基-1,3-苯并恶嗪1d完全不发生聚合反应。©2011 Wiley Periodicals，Inc. J Polym Sci A部分：Polym Chem，2011年
• Specific spectroscopic behavior of Reichardt's betaine dye in binary mixtures of tetra-n-butylammonium glycinate and tetra-n-butylammonium l-alaninate with molecular solvents
  作者：Ali Reza Harifi-Mood、Meysam Aryafard、Babak Minoofar、Azim Ziyaei-Halimehjani

  DOI：10.1016/j.molliq.2014.05.010

  日期：2014.9

  spectrophotometrical behavior of pyridinium N-phenolate betaine dye used as a solvatochromic indicator of solvent polarity is studied in binary mixtures of tetra-n-butylammonium glycinate and tetra-n-butylammonium l-alaninate with molecular solvents such as acetonitrile, ethyl acetate, and 1-butanol. This study shows that the solvent/solvent interactions, which cause preferential solvation of the dye solute, should

  在甘氨酸四正丁基铵和四正丁基铵l的二元混合物中研究了吡啶鎓N-酚盐甜菜碱染料的分光光度行为，作为溶剂极性的变色指示剂用分子溶剂（如乙腈，乙酸乙酯和1-丁醇）进行丙氨酸酯化。这项研究表明，对于使用常规分子溶剂混合物的氨基酸基离子液体，不应建立引起染料溶质优先溶剂化的溶剂/溶剂相互作用。加入离子液体的摩尔分数后，甜菜碱染料的分子内电荷转移吸收光谱显示出双峰结构。UV-Vis光谱的变化证明了与分子溶剂类型的关系。分子动力学模拟显示甜菜碱染料的溶剂化壳中的组成明显不同。