(E)-1-(furan-2-yl)-3-(3-hydroxyphenyl)prop-2-en-1-one | 105904-51-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-1-(furan-2-yl)-3-(3-hydroxyphenyl)prop-2-en-1-one
• 英文别名: 1-(furan-2-yl)-3-(3-hydroxyphenyl)-2-propene-1-one；1-[2]furyl-3t-(3-hydroxy-phenyl)-propenone；1-[2]Furyl-3t-(3-hydroxy-phenyl)-propenon
• CAS: 105904-51-6
• 化学式: C₁₃H₁₀O₃
• 分子量: 214.221
• InChiKey: ZNRZXBKRQBQRRO-VOTSOKGWSA-N

物化性质

• 熔点：
  144.5-146 °C(Solv: benzene (71-43-2))
• 沸点：
  396.7±42.0 °C(Predicted)
• 密度：
  1.252±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-肼基苯并噻唑 、 (E)-1-(furan-2-yl)-3-(3-hydroxyphenyl)prop-2-en-1-one 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 3-(1-(benzo[d]thiazol-2-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)phenol
  参考文献：
  名称：

  Thiophene and furan appended pyrazoline based fluorescent chemosensors for detection of Al3+ ion

  摘要：

  Thiophene and furan appended pyrazoline receptors R1 and R2 were designed and synthesized for selective detection of Al3+ ion. Their photophysical properties were studied by UV-visible and fluorescence spectra. Surprisingly, both receptors R1 and R2 were displayed an excellent selective and sensitive response to Al3+ ion alone over other tested metal ions. Both the receptor R1 and R2 displays 1:1 stoichiometry for [R1-Al3+] and [R2-Al3+] complex and formed with an association constant of 1.84 x 10(4) M-1 and 1.92 x 10(4) M-1 respectively. The limit of detection were calculated for R1 and R2 since 8.92 x 10(-8) M and 1.04 x 10(-7) M by the fluorescence titration method. The thiophene based receptor R1 exhibited superior chemosensor characteristics such as high intensity absorption and emission at longer wavelength as compered that of furan based receptor R2.

  DOI：

  10.1016/j.inoche.2019.01.038
• 作为产物：
  描述：

  2-乙酰基呋喃 、 间羟基苯甲醛 在 potassium hydroxide 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 以58%的产率得到(E)-1-(furan-2-yl)-3-(3-hydroxyphenyl)prop-2-en-1-one
  参考文献：
  名称：

  Simple, Rapid and Reliable Preparation of [11C]-(+)-a-DTBZ of High Quality for Routine Applications

  摘要：

  [11C]-(+)-a-DTBZ已被用作人类纹状体中多巴胺能终端密度的标记物，并在胰腺的胰岛β细胞中表达。我们旨在建立一个完全自动化和简单的程序，以合成[11C]-(+)-a-DTBZ，以便进行常规应用。[11C]-(+)-a-DTBZ是从一种9-羟基前体在丙酮和氢氧化钾的条件下与[11C]-甲基三氟甲磺酸酯合成的，并通过使用Vac tC-18柱的固相提取进行纯化。基于[11C]-甲基三氟甲磺酸酯（已校正衰减）的放射化学产率为82.3% ± 3.6%，具有60 GBq/mmol的比放射活性。从轰击结束到产品释放进行质量控制的时间少于20分钟。

  DOI：

  10.3390/molecules17066697

文献信息

• [EN] CHALCONES AS ENHANCER OF ANTIMICROBIAL AGENTS<br/>[FR] CHALCONES EN TANT QU'AMPLIFICATRICES D'AGENTS ANTIMICROBIENS
  申请人：COLGATE PALMOLIVE CO

  公开号：WO2011075136A1

  公开（公告）日：2011-06-23

  Compounds are described that are effective in enhancing the efficacy of antimicrobial agents. Also described are methods of using such compounds and compositions that include such compounds. The composition includes a chalcone compound and, optionally, an antimicrobial agent.

  描述了一种有效增强抗微生物药物功效的化合物。还描述了使用这种化合物的方法和包含这种化合物的组合物。该组合物包括一种查尔酮化合物，可选地，还包括抗微生物药物。
• CHALCONES AS ENHANCER OF ANTIMICROBIAL AGENTS
  申请人：Subramanyam Ravi

  公开号：US20120251464A1

  公开（公告）日：2012-10-04

  Compounds are described that are effective in enhancing the efficacy of antimicrobial agents. Also described are methods of using such compounds and compositions that include such compounds. The composition includes a chalcone compound and, optionally, an antimicrobial agent.

  本文描述了一些能够增强抗微生物药物疗效的化合物。同时还描述了使用这些化合物的方法和包含这些化合物的组合物。该组合物包括查尔酮化合物和可选的抗微生物药物。
• Heterocyclic chalcone compounds
  申请人：LASDON FOUNDATION INC

  公开号：US02754299A1

  公开（公告）日：1956-07-10
• US9192589B2
  申请人：——

  公开号：US9192589B2

  公开（公告）日：2015-11-24
• Simple, Rapid and Reliable Preparation of [11C]-(+)-a-DTBZ of High Quality for Routine Applications
  作者：Jinming Zhang、Xiaojun Zhang、Yungang Li、Jiahe Tian

  DOI：10.3390/molecules17066697

  日期：——

  [11C]-(+)-a-DTBZ has been used as a marker of dopaminergic terminal densities in human striatum and expressed in islet beta cells in the pancreas. We aimed to establish a fully automated and simple procedure for the synthesis of [11C]-(+)-a-DTBZ for routine applications. [11C]-(+)-a-DTBZ was synthesized from a 9-hydroxy precursor in acetone and potassium hydroxide with [11C]-methyl triflate and was purified by solid phase extraction using a Vac tC-18 cartridge. Radiochemical yields based on [11C]-methyl triflate (corrected for decay) were 82.3% ± 3.6%, with a specific radioactivity of 60 GBq/mmol. Time elapsed was less than 20 min from end of bombardment to release of the product for quality control.

  [11C]-(+)-a-DTBZ已被用作人类纹状体中多巴胺能终端密度的标记物，并在胰腺的胰岛β细胞中表达。我们旨在建立一个完全自动化和简单的程序，以合成[11C]-(+)-a-DTBZ，以便进行常规应用。[11C]-(+)-a-DTBZ是从一种9-羟基前体在丙酮和氢氧化钾的条件下与[11C]-甲基三氟甲磺酸酯合成的，并通过使用Vac tC-18柱的固相提取进行纯化。基于[11C]-甲基三氟甲磺酸酯（已校正衰减）的放射化学产率为82.3% ± 3.6%，具有60 GBq/mmol的比放射活性。从轰击结束到产品释放进行质量控制的时间少于20分钟。