1-tetracosyl bromide | 6946-24-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: 1-tetracosyl bromide
• 英文别名: 1-bromotetracosane；1-bromo-tetracosane；tetracosyl bromide；1-Brom-tetracosan；Tetracosylbromid；Tetracosanylbromid
• CAS: 6946-24-3
• 化学式: C₂₄H₄₉Br
• 分子量: 417.557
• InChiKey: ZGPCRVNHYNSDIH-UHFFFAOYSA-N

物化性质

• 熔点：
  50.7°C
• 沸点：
  444.34°C (rough estimate)
• 密度：
  0.9876 (rough estimate)
• 保留指数：
  369.5

计算性质

• 辛醇/水分配系数(LogP)：
  13.6
• 重原子数：
  25
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-tetracosyl bromide 在 sodium iodide 作用下， 以 丙酮 为溶剂， 生成 1-iodotetracosane
  参考文献：
  名称：

  与霉菌酸有关的3-羟基-2-烷基羧酸

  摘要：

  报道了一系列在结构上类似于霉菌酸的长链3-羟基-2-烷基酸。使用3-酮酸酯作为中间体进行的合成允许插入与主酸链没有结构关系的2-烷基。

  DOI：

  10.1016/0040-4020(79)88026-6
• 作为产物：
  描述：

  1-癸炔 在 palladium on activated charcoal 正丁基锂 、 硫酸 、 氢溴酸 、 氢气 、 sodium hydride 、 乙二胺 作用下， 以 六甲基磷酰三胺 、 乙醇 为溶剂， 生成 1-tetracosyl bromide
  参考文献：
  名称：

  Hyperextended amphiphiles. Bilayer formation from single-tailed compounds

  摘要：

  DOI：

  10.1021/ja00062a086
• 作为试剂：
  描述：

  、 、 三苯基膦 、 四溴化碳 、 二十四烷醇 在 1-tetracosyl bromide 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以the produced 1-tetracosyl bromide was isolated from the reaction mixture by column chromatography的产率得到1-tetracosyl bromide
  参考文献：
  名称：

  ZEOLITES WITH INCORPORATED DIPOLAR NONLINEAR OPTICAL MOLECULES IN UNIFORM ORIENTATION AND PREPARATION THEREOF

  摘要：

  本发明涉及一种制备均匀排列的沸石超晶体的方法，包括在均匀排列的模板中生长沸石或沸石型材料的晶体，从而制备出均匀排列的沸石超晶体，以及一种均匀排列的沸石超晶体。本发明的均匀排列的沸石超晶体预计通过克服随机定向沸石的缺点来最大化其适用性。

  公开号：

  US20060219989A1

文献信息

• Compounds comprising sulfated nonulonic acid having antiviral activity
  申请人：Nissan Food Products Co., Ltd.

  公开号：US06337390B1

  公开（公告）日：2002-01-08

  In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.

  为了提供具有低抗凝作用和低细胞毒性的抗逆转录病毒活性化合物，提供了包含糖苷或其盐的化合物，其中脂质连接到唾液酸的第2位，其4、7、8和9位的所有羟基完全磺酸化，或者KDN（2-酮-3-脱氧-D-甘油酸）的4、5、7、8和9位的所有羟基完全磺酸化。
• An expedient synthesis of 5-<i>n</i>-alkylresorcinols and novel 5-<i>n</i>-alkylresorcinol haptens
  作者：Kirsti Parikka、Kristiina Wähälä

  DOI：10.3762/bjoc.5.22

  日期：——

  The first synthesis of bioactive long alkyl chain 5-n-alkylresorcinols, present in whole grain products, by a novel modification of the Wittig reaction is described. All the main long chain 5-n-alkylresorcinols present in rye and wheat, including C₂₃ and C₂₅ analogues and haptens, which have not been previously prepared, were synthesised. Microwave-promoted reactions of a semi-stabilized ylid and alkanals in water gave good yields in both pressurized and open systems. An alternative microwave-promoted synthesis starting from non-stabilized alkyltriphenylphosphonium salts and 3,5-dimethoxybenzaldehyde worked as well. Aqueous media were suitable for the reactions even if the starting materials were not soluble in water. The 5-n-alkylresorcinols are potential biomarkers of whole grain intake, and the new hapten derivatives of 5-n-alkylresorcinols will open the way for the immunochemical detection techniques of alkylresorcinols.

  描述了通过一种新颖的Wittig反应改进合成生物活性长烷基链5-烷基间苯二酚，这种物质存在于全谷物产品中。合成了黑麦和小麦中所有主要的长链5-烷基间苯二酚，包括C23和C25类似物以及以前未制备的半抗原。在水中，半稳定叶立德和烷醛的微波促进反应在加压和开放系统中均获得良好产率。另一种微波促进合成方法是从非稳定的烷基三苯基膦盐和3,5-二甲氧基苯甲醛出发。即使起始材料在水中不溶解，水介质也适用于这些反应。5-烷基间苯二酚是全谷物摄入的潜在生物标志物，而新的5-烷基间苯二酚半抗原衍生物将为烷基间苯二酚的免疫化学检测技术打开道路。
• Comparison of the Antiviral Activities of Alkoxyalkyl and Alkyl Esters of Cidofovir against Human and Murine Cytomegalovirus Replication In Vitro
  作者：William B. Wan、James R. Beadle、Caroll Hartline、Earl R. Kern、Stephanie L. Ciesla、Nadejda Valiaeva、Karl Y. Hostetler

  DOI：10.1128/aac.49.2.656-662.2005

  日期：2005.2

  Alkoxyalkyl esters of cidofovir (CDV) have substantially greater antiviral activity and selectivity than unmodified CDV against herpesviruses and orthopoxviruses in vitro. Enhancement of antiviral activity was also noted when cyclic CDV was esterified with alkoxyalkanols. In vitro antiviral activity of the most active analogs against human cytomegalovirus (HCMV) and orthopoxviruses was increased relative to CDV up to 1,000- or 200-fold, respectively. Alkyl chain length and linker structure are important potential modifiers of antiviral activity and selectivity. In this study, we synthesized a series of alkoxyalkyl esters of CDV or cyclic CDV with alkyl chains from 8 to 24 atoms and having linker moieties of glycerol, propanediol, and ethanediol. We also synthesized alkyl esters of CDV which lack the linker to determine if the alkoxyalkyl linker moiety is required for activity. The new compounds were evaluated in vitro against HCMV and murine CMV (MCMV). CDV or cyclic CDV analogs both with and without linker moieties were highly active against HCMV and MCMV, and their activities were strongly dependent on chain length. The most active compounds had 20 atoms esterified to the phosphonate of CDV. Both alkoxypropyl and alkyl esters of CDV provided enhanced antiviral activities against CMV in vitro. Thus, the oxypropyl linker moiety is not required for enhanced activity. CDV analogs having alkyl ethers linked to glycerol or ethanediol linker groups also demonstrated increased activity against CMV.

  摘要 西多福韦（CDV）的烷氧基烷基酯在体外对疱疹病毒和正疱疹病毒的抗病毒活性和选择性大大高于未改性的 CDV。当环状 CDV 与烷氧基烷醇酯化时，抗病毒活性也会增强。与 CDV 相比，最活跃的类似物对人类巨细胞病毒（HCMV）和正痘病毒的体外抗病毒活性分别提高了 1000 倍和 200 倍。烷基链长度和连接体结构是抗病毒活性和选择性的重要潜在调节剂。在这项研究中，我们合成了一系列 CDV 烷氧基烷基酯或环 CDV 烷氧基烷基酯，其烷基链长度为 8 至 24 个原子，链接分子为甘油、丙二醇和乙二醇。我们还合成了缺少连接基的 CDV 烷基酯，以确定烷氧基烷基连接基是否为活性所必需。我们对这些新化合物进行了抗 HCMV 和小鼠 CMV (MCMV) 的体外评估。含有或不含连接基的 CDV 或环状 CDV 类似物对 HCMV 和 MCMV 都具有很高的活性，而且它们的活性与链长密切相关。活性最强的化合物有 20 个原子酯化到 CDV 的膦酸盐上。CDV 的烷氧基丙基酯和烷基酯都能在体外增强对 CMV 的抗病毒活性。因此，增强活性并不需要氧丙基连接分子。烷基醚与甘油或乙二醇连接基连接的 CDV 类似物也显示出更强的抗 CMV 活性。
• Identification of very long chain fatty acids from sugar cane wax by atmospheric pressure chemical ionization liquid chromatography–mass spectroscopy
  作者：Tomáš Řezanka、Karel Sigler

  DOI：10.1016/j.phytochem.2006.02.014

  日期：2006.5

  enrichment of very long chain fatty acids (VLCFAs) from total fatty acids of sugar cane wax and their identification as picolinyl esters by means of liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization (LC-MS/APCI). The method is based on the use of preparative reversed phase HPLC of 100 mg amounts and their subsequent identification by microbore APCI LC-MS. The combination of

  描述了一种从甘蔗蜡的总脂肪酸中富集超长链脂肪酸 (VLCFA) 并通过液相色谱-质谱联用常压化学电离 (LC-MS/APCI) 将其鉴定为吡啶甲基酯的方法. 该方法基于使用 100 mg 量的制备型反相 HPLC 并随后通过微孔 APCI LC-MS 进行鉴定。这两种技术的组合被用来识别高达 C(50) 的不寻常饱和 VLCFA。
• Pharmacologically active agents containing esterified phosphonates and methods for use thereof
  申请人：Hostetler Y. Karl

  公开号：US20050192246A1

  公开（公告）日：2005-09-01

  Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections, cell proliferation and bone metabolism. The compounds provided herein are alkyl esters of phosphonates.

  提供了用于治疗、预防或改善与病毒感染、细胞增殖和骨代谢相关的各种医学疾病的化合物和组合物。本文提供的化合物是磷酸酯的烷基酯。

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