2,3-环氧-1,4-苯醌 | 15254-69-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,3-环氧-1,4-苯醌
• 英文名称: benzoquinoepoxide
• 英文别名: 2,3-epoxy-1,4-benzoquinone；2,5-Dioxo-7-oxa-bicyclo<4.1.0>hepten-(3)；Chinonoxid；5,6-epoxy-cyclohex-2-ene-1,4-dione；7-Oxabicyclo[4.1.0]hept-3-ene-2,5-dione
• CAS: 15254-69-0
• 化学式: C₆H₄O₃
• 分子量: 124.096
• InChiKey: XQUCGJMSQRPJEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.7
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  2,3-环氧-1,4-苯醌 、 甲基三苯基溴化膦 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 0.75h， 以39%的产率得到3,6-dimethylidene-1,2-epoxy-4-cyclohexene
  参考文献：
  名称：

  A New Catalytic and Enantioselective Desymmetrization of Symmetrical Methylidene Cycloalkene Oxides

  摘要：

  [GRAPHICS]Chiral copper complexes of C-2-symmetrical phosphoroamidites were found to be highly effective catalysts for both kinetic resolution and novel desymmetrization reactions of new methylidene epoxycycloalkanes.

  DOI：

  10.1021/ol005584o
• 作为产物：
  描述：

  5-氧杂四环[7.2.1.0(2,8).0(4,6)]十二烷-10-烯-3,7-二酮 生成 2,3-环氧-1,4-苯醌
  参考文献：
  名称：

  A New Catalytic and Enantioselective Desymmetrization of Symmetrical Methylidene Cycloalkene Oxides

  摘要：

  [GRAPHICS]Chiral copper complexes of C-2-symmetrical phosphoroamidites were found to be highly effective catalysts for both kinetic resolution and novel desymmetrization reactions of new methylidene epoxycycloalkanes.

  DOI：

  10.1021/ol005584o

文献信息

• Competitive epoxidation and quinone formation in the dimethyldioxirane oxidation of diazoquinones as ambident nucleophiles
  作者：Waldemar Adam、Lazaros Hadjiarapoglou、Karsten Mielke、Alexander Treiber

  DOI：10.1016/s0040-4039(00)77264-9

  日期：1994.8

  In addition to the expected dimethyldioxirane (DMD) oxidation of diazoquinones 1 to their quinones 2, the corresponding epoxy quinones 3 are formed directly and not as secondary overoxidation products of the quinones 2 since the latter are persistent towards DMD under these conditions; this novel oxidation is rationalized in terms of the ambident nucleophilic nature of the diazoquinones and corroborated

  除了重氮醌1预期的二甲基二环氧乙烷（DMD）氧化成其醌2外，相应的环氧醌3是直接形成的，而不是醌2的二次过氧化产物，因为后者在这些条件下对DMD具有持久性。根据重氮醌的亲核性质合理地解释了这种新颖的氧化反应，并通过MO（AM1）计算得到了证实。
• HKOCl-2 Series of Green BODIPY-Based Fluorescent Probes for Hypochlorous Acid Detection and Imaging in Live Cells
  作者：Jun Jacob Hu、Nai-Kei Wong、Qiangshuai Gu、Xiaoyu Bai、Sen Ye、Dan Yang

  DOI：10.1021/ol501496n

  日期：2014.7.3

  A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macrophages. These probes could therefore serve as promising discovery tools to help elucidate biological functions

  报道了用于活细胞中次氯酸（HOCl）检测的HKOCl-2系列新荧光探针。探针表现出优异的选择性，灵敏度和对HOCl的化学稳定性。特别地，HKOC1-2b迅速且选择性地检测人和小鼠巨噬细胞中的内源性HOCl。因此，这些探针可以用作有希望的发现工具，以帮助阐明HOC1的生物学功能。
• Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors
  申请人：Floyd Jr Brawner Middleton

  公开号：US20070299092A1

  公开（公告）日：2007-12-27

  The present invention provides for compounds with the general formula: A compound of formula (1) having the structure (1) wherein Z is a radical selected from the group (a), (b), or (c) as well as methods and compositions containing these compounds useful for treatment of diseases that are characterized, at least in part, by excessive, abnormal, or inappropriate angiogenesis. These disease states, include but are not limited to, cancer, diabetic retinopathy, macular degeneration and rheumatoid arthritis. These compounds inhibit angiogenesis by inhibiting a tyrosine kinase receptor enzyme, specifically KDR, and binding to the KDR in an irreversible manner.

  本发明提供了一般式为：具有结构式（1）的化合物，其中Z是从（a）、（b）或（c）组中选择的基团，以及包含这些化合物的方法和组合物，用于治疗至少部分特征为过度、异常或不适当血管生成的疾病。这些疾病状态包括但不限于癌症、糖尿病视网膜病变、黄斑变性和类风湿性关节炎。这些化合物通过抑制酪氨酸激酶受体酶，特别是KDR，并以不可逆的方式与KDR结合来抑制血管生成。
• Dual-color HIV reporter system for the detection of latently-infected cells
  申请人：THE J. DAVID GLADSTONE INSTITUTES

  公开号：US10106818B2

  公开（公告）日：2018-10-23

  The present disclosure provides for recombinant nucleic acids, and cells and virions comprising the recombinant nucleic acids, that can be used to identify, isolate, and/or purify cells latently infected with immunodeficiency virus. A subject recombinant nucleic acid includes (a) a first nucleotide sequence encoding a first reporter polypeptide that produces a first detectable signal, where the first nucleotide sequence is operably linked to an immunodeficiency virus promoter and is translated as an early gene; and (b) a second nucleotide sequence encoding a second reporter polypeptide that produces a second detectable signal that is distinguishable from the first detectable signal, where the second nucleotide sequence is operably linked to a non-immunodeficiency virus promoter. In some aspects, the first and second nucleotide sequences are both positioned between a shared 5′ long terminal repeat (LTR) and a shared 3′ LTR. Also provided are related methods.

  本公开提供了重组核酸以及包含重组核酸的细胞和病毒，可用于鉴定、分离和/或纯化潜伏感染免疫缺陷病毒的细胞。受试重组核酸包括：(a) 第一核苷酸序列，编码产生第一检测信号的第一报告基因多肽，其中第一核苷酸序列与免疫缺陷病毒启动子可操作连接，并作为早期基因翻译；(b) 编码第二报告基因多肽的第二核苷酸序列，它产生的第二检测信号与第一检测信号不同，其中第二核苷酸序列与非免疫缺陷病毒启动子可操作地连接。在某些方面，第一和第二核苷酸序列都位于共享的 5′长末端重复序列（LTR）和共享的 3′长末端重复序列（LTR）之间。还提供了相关的方法。
• Coxon, James M.; O'Connell, Michael J.; Steel, Peter J., Australian Journal of Chemistry, 1986, vol. 39, # 10, p. 1537 - 1557
  作者：Coxon, James M.、O'Connell, Michael J.、Steel, Peter J.

  DOI：——

  日期：——