(2R,3R,4S,5R,6R)-2-[(2R,3R,4R,5R,6S)-6-((2R,3S,4R,5R)-6-Benzyloxy-4,5-dihydroxy-2-hydroxymethyl-tetrahydro-pyran-3-yloxy)-4,5-dihydroxy-2-hydroxymethyl-tetrahydro-pyran-3-yloxy]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol | 642441-76-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4S,5R,6R)-2-[(2R,3R,4R,5R,6S)-6-((2R,3S,4R,5R)-6-Benzyloxy-4,5-dihydroxy-2-hydroxymethyl-tetrahydro-pyran-3-yloxy)-4,5-dihydroxy-2-hydroxymethyl-tetrahydro-pyran-3-yloxy]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol
• 英文别名: Gal(a1-4)Gal(b1-4)Glc-O-Bn；(2R,3R,4S,5R,6R)-2-[(2R,3R,4R,5R,6S)-6-[(2R,3S,4R,5R)-4,5-dihydroxy-2-(hydroxymethyl)-6-phenylmethoxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 642441-76-7
• 化学式: C₂₅H₃₈O₁₆
• 分子量: 594.567
• InChiKey: MHJLZPNUWVYFMR-VFKZMABYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  41
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  258
• 氢给体数：
  10
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  uridine 5'-diphospho-N-acetylglucosamine 、 (2R,3R,4S,5R,6R)-2-[(2R,3R,4R,5R,6S)-6-((2R,3S,4R,5R)-6-Benzyloxy-4,5-dihydroxy-2-hydroxymethyl-tetrahydro-pyran-3-yloxy)-4,5-dihydroxy-2-hydroxymethyl-tetrahydro-pyran-3-yloxy]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol 在 α(1->4) galactosyltransferase β(1->3)N-acetylgalactosaminyltransferase-WbgU fusion enzyme 、 manganese(ll) chloride 、 bovine serum albumin 作用下， 以 various solvent(s) 为溶剂， 反应 48.0h， 以78%的产率得到benzyl β-D-N-acetyl-galactosaminyl-(1->3)-α-D-galactopyranosyl-(1->4)-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside
  参考文献：
  名称：

  Efficient synthesis of globoside and isogloboside tetrasaccharides by using β(1→3) N-acetylgalactosaminyltransferase/UDP-N-acetylglucosamine C4 epimerase fusion protein

  摘要：

  构建了β(1→3)N-乙酰半乳糖胺基转移酶/UDP-N-乙酰葡萄糖胺C4差向异构酶融合蛋白，并将其用于耦合酶促反应，以相应的乳糖苷受体为原料合成了多种四糖和异四糖衍生物。

  DOI：

  10.1039/b300831b
• 作为产物：
  描述：

  尿苷(5')二氢二磷酰(1)-alpha-D-葡萄糖 、 benzyl α,β-lactoside 在 α(1->4)galactosyltransferase from N. meningitidis 、 GalE from Escherichia coli K₁₂ 作用下， 生成 (2R,3R,4S,5R,6R)-2-[(2R,3R,4R,5R,6S)-6-((2R,3S,4R,5R)-6-Benzyloxy-4,5-dihydroxy-2-hydroxymethyl-tetrahydro-pyran-3-yloxy)-4,5-dihydroxy-2-hydroxymethyl-tetrahydro-pyran-3-yloxy]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol
  参考文献：
  名称：

  Efficient synthesis of globoside and isogloboside tetrasaccharides by using β(1→3) N-acetylgalactosaminyltransferase/UDP-N-acetylglucosamine C4 epimerase fusion protein

  摘要：

  构建了β(1→3)N-乙酰半乳糖胺基转移酶/UDP-N-乙酰葡萄糖胺C4差向异构酶融合蛋白，并将其用于耦合酶促反应，以相应的乳糖苷受体为原料合成了多种四糖和异四糖衍生物。

  DOI：

  10.1039/b300831b

文献信息

• Efficient synthesis of globoside and isogloboside tetrasaccharides by using β(1→3) N-acetylgalactosaminyltransferase/UDP-N-acetylglucosamine C4 epimerase fusion protein
  作者：Jun Shao、Jianbo Zhang、Przemyslaw Kowal、Yuquan Lu、Peng George Wang

  DOI：10.1039/b300831b

  日期：——

  The β(1→3) N-acetylgalactosaminyltransferase/UDP-N-acetylglucosamine C4 epimerase fusion protein was constructed and used in coupled enzymatic reactions to synthesize a variety of globotetraose and isoglobotetraose derivatives from the corresponding lactoside acceptors.

  构建了β(1→3)N-乙酰半乳糖胺基转移酶/UDP-N-乙酰葡萄糖胺C4差向异构酶融合蛋白，并将其用于耦合酶促反应，以相应的乳糖苷受体为原料合成了多种四糖和异四糖衍生物。