1-(3-Fluoro-4-methoxyphenyl)indole | 118575-84-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-(3-Fluoro-4-methoxyphenyl)indole
• CAS: 118575-84-1
• 化学式: C₁₅H₁₂FNO
• 分子量: 241.265
• InChiKey: BCIYGRKNVQHPJC-UHFFFAOYSA-N

物化性质

• 沸点：
  374.8±42.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  14.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3-Fluoro-4-methoxyphenyl)indole 在 N-氯代丁二酰亚胺 、 磷酸 、 溶剂黄146 作用下， 生成 1-(3-Fluoro-4-methoxyphenyl)oxindole
  参考文献：
  名称：

  A novel class of "GABAergic" agents: 1-aryl-3-(aminoalkylidene)oxindoles

  摘要：

  Antagonism of mercaptopropionic acid (MPA) induced convulsions, reflecting a GABAergic mechanism, was observed in a series of 1-aryl-3-(aminoalkylidene)oxindoles. Optimal MPA antagonism was associated with 3-halo, 3-alkyl, and/or 4-alkoxy substituents in the pendant aryl ring and with (dimethylamino)methylene, 1-(dimethylamino)-ethylidene and N-methyl-2-pyrrolidinylidene side chains. The precise mechanism of action of these agents is unclear at this time; however, they are not GABA mimics and they do not affect GABA levels. Like other GABAergic agents, these compounds are potent enhancers of benzodiazepine binding and they antagonize cyclic GMP elevations induced by isoniazid. Compounds from this series may therefore have potential therapeutic utility as anticonvulsants or anxiolytics.

  DOI：

  10.1021/jm00122a025
• 作为产物：
  描述：

  吲哚 、 4-溴-2-氟苯甲醚 在 N-甲基吡咯烷酮 、 copper(I) bromide 、 potassium carbonate 作用下， 以35%的产率得到1-(3-Fluoro-4-methoxyphenyl)indole
  参考文献：
  名称：

  A novel class of "GABAergic" agents: 1-aryl-3-(aminoalkylidene)oxindoles

  摘要：

  Antagonism of mercaptopropionic acid (MPA) induced convulsions, reflecting a GABAergic mechanism, was observed in a series of 1-aryl-3-(aminoalkylidene)oxindoles. Optimal MPA antagonism was associated with 3-halo, 3-alkyl, and/or 4-alkoxy substituents in the pendant aryl ring and with (dimethylamino)methylene, 1-(dimethylamino)-ethylidene and N-methyl-2-pyrrolidinylidene side chains. The precise mechanism of action of these agents is unclear at this time; however, they are not GABA mimics and they do not affect GABA levels. Like other GABAergic agents, these compounds are potent enhancers of benzodiazepine binding and they antagonize cyclic GMP elevations induced by isoniazid. Compounds from this series may therefore have potential therapeutic utility as anticonvulsants or anxiolytics.

  DOI：

  10.1021/jm00122a025

文献信息

• Heteroylidene indolone compounds
  申请人：Pfizer Inc.

  公开号：US04476307A1

  公开（公告）日：1984-10-09

  Certain substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones are highly potent gabaergic agents, valuable in the treatment of individuals suffering from schizophrenia or reversing the side effects of a previously or concurrently administered neuroleptic agent; or in the treatment of epilepsy. A wider class of substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones, together with 1-phenyl-3-(2-pyrrolidinylidene)-2(1H,3H)-indolones, and homologs thereof, are valuable in the treatment of anxiety.

  某些取代的1-苯基-3-(氨基烯基)-2(1H,3H)-吲哚酮是高效的GABA能药物，在治疗患有精神分裂症的个体或逆转先前或同时使用的神经阻滞剂药物的副作用方面非常有价值；或者在癫痫的治疗中。更广泛的一类取代的1-苯基-3-(氨基烯基)-2(1H,3H)-吲哚酮，以及1-苯基-3-(2-吡咯烯基)-2(1H,3H)-吲哚酮及其同系物，在焦虑症的治疗中非常有价值。
• Method of treating anxiety and depression with
  申请人：Pfizer Inc.

  公开号：US04977178A1

  公开（公告）日：1990-12-11

  Certain substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones are highly potent gabaergic agents, valuable in the treatment of individuals suffering from schizophrenia or reversing the side effects of a previously or concurrently administered neuroleptic agent; or in the treatment of epilepsy. A wider class of substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones, together with 1-phenyl-3-(2-pyrrolidinylidene)-2(1H,3H)-indolones, and homologs thereof, are valuable in the treatment of anxiety.

  某些取代的1-苯基-3-(氨基烷基亚甲基)-2(1H,3H)-吲哚酮是高效的GABA能药物，在治疗患有精神分裂症或逆转先前或同时给予的神经阻滞剂药物的副作用方面非常有价值；或在治疗癫痫方面也非常有价值。更广泛的一类取代的1-苯基-3-(氨基烷基亚甲基)-2(1H,3H)-吲哚酮，以及1-苯基-3-(2-吡咯烷亚甲基)-2(1H,3H)-吲哚酮及其同系物，在治疗焦虑方面也非常有价值。
• 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents
  申请人：Pfizer Inc.

  公开号：US04861880A1

  公开（公告）日：1989-08-29

  Certain substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones are highly potent gabaergic agents, valuable in the treatment of individuals suffering from schizophrenia or reversing the side effects of a previously or concurrently administered neuroleptic agent; or in the treatment of epilepsy. A wider class of substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones, together with 1-phenyl-3-(2-pyrrolidinylidene)-2(1H,3H)-indolones, and homologs thereof, are valuable in the treatment of anxiety.

  某些取代的1-苯基-3-(氨基烷基亚甲基)-2(1H,3H)-吲哚酮是高效的GABA能药物，在治疗患有精神分裂症或逆转先前或同时给予的神经类药物的副作用，或治疗癫痫方面具有价值。更广泛的一类取代的1-苯基-3-(氨基烷基亚甲基)-2(1H,3H)-吲哚酮，连同1-苯基-3-(2-吡咯烷基亚甲基)-2(1H,3H)-吲哚酮及其同系物，在治疗焦虑方面具有价值。
• 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents
  申请人：Pfizer Inc.

  公开号：US04879391A1

  公开（公告）日：1989-11-07

  Certain substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones are highly potent gabaergic agents, valuable in the treatment of individuals suffering from schizophrenia or reversing the side effects of a previously or concurrently administered neuroleptic agent; or in the treatment of epilepsy. A wider class of substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones, together with 1-phenyl-3-(2-pyrrolidinylidiene-2(1H,3H)-indolones, and homologs thereof, are valuable in the treatment of anxiety.

  某些取代的1-苯基-3-(氨基烷基亚甲基)-2(1H,3H)-吲哚酮是高效的GABA能药物，在治疗患有精神分裂症或逆转先前或同时给予的神经类药物副作用方面非常有价值；或在治疗癫痫方面也有用。更广泛的取代的1-苯基-3-(氨基烷基亚甲基)-2(1H,3H)-吲哚酮，连同1-苯基-3-(2-吡咯烷基亚甲基)-2(1H,3H)-吲哚酮及其同系物，在治疗焦虑方面也很有价值。
• 1-Phenyl-2(1H,3H)-indolone psycho-therapeutic agents
  申请人：PFIZER INC.

  公开号：EP0104860A1

  公开（公告）日：1984-04-04

  Certain substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones are highly potent gabaergic agents, valuable in the treatment of individuals suffering from schizophrenia or reversing the side effects of a previously or concurrently administered neuroleptic agent; or in the treatment of epilepsy. A wider class of substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones, together with 1-phenyl-3-(2-pyrrolidinylidene)-2(1H,3H)-indolones, and homologs thereof, are valuable in the treatment of anxiety.

  某些取代的 1-苯基-3-(氨基亚烷基)-2(1H,3H)-吲哚酮是强效的伽巴能药物，对治疗精神分裂症患者或逆转之前或同时使用的神经安定剂的副作用，或治疗癫痫很有价值。还有一类取代的 1-苯基-3-(氨基亚烷基)-2(1H,3H)-吲哚酮，以及 1-苯基-3-(2-吡咯烷亚基)-2(1H,3H)-吲哚酮及其同系物，对治疗焦虑症很有价值。