4-苯基-4-哌啶环己醇 | 60756-83-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-苯基-4-哌啶环己醇
• 英文名称: 1-phenyl-1-piperidino-4-cyclohexanol
• 英文别名: 4-phenyl-4-(1-piperidinyl)cyclohexanol；-phenyl-4-piperidino-cyclohexanol；4-Phenyl-4-piperidinocyclohexanol；4-Hydroxyxyclohexyl-Phencyclidine；4-phenyl-4-piperidin-1-yl-cyclohexanol；4-phenyl-4-piperidin-1-ylcyclohexan-1-ol
• CAS: 60756-83-4
• 化学式: C₁₇H₂₅NO
• 分子量: 259.392
• InChiKey: KPRUAZBLIREHPD-UHFFFAOYSA-N

物化性质

• 保留指数：
  2549

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

ADMET

代谢

C-PPC/t-PPC 是苯环利定（PCP）的一种已知人体代谢物。

C-PPC/t-PPC is a known human metabolite of phencyclidine.

来源:NORMAN Suspect List Exchange

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  4-苯基-4-哌啶环己醇 以 水 、 溶剂黄146 为溶剂， 以93%的产率得到4-Phenyl-4-(1-piperidinyl)cyclohexanon
  参考文献：
  名称：

  Phencyclidine compounds and assays for its determination

  摘要：

  提供了新颖的苯环哌啶羟肟衍生物，作为与蛋白质结合的前体，可用于制备抗体或酶结合物，这些抗体和酶结合物可用作免疫分析中的试剂。抗体和酶结合物的组合提供了对苯环哌啶的敏感、准确、快速的检测方法，而且不受常用药物（如右美沙芬、哌替啶和氯丙嗪）的干扰。

  公开号：

  US04446065A1
• 作为产物：
  描述：

  4-Benzoyloxy-1-piperidinocyclohexanecarbonitrile 生成 4-苯基-4-哌啶环己醇
  参考文献：
  名称：

  LIN, CHENG-I.;SINGH, PRITHIPAL

  摘要：

  DOI：

文献信息

• Application of chemical P450 model systems to studies on drug metabolism. I. Phencyclidine. A multi-functional model substrate.
  作者：Hiroshi MASUMOTO、Kaoru TAKEUCHI、Shigeru OHTA、Masaaki HIROBE

  DOI：10.1248/cpb.37.1788

  日期：——

  Cytochrome P450 model and liver microsomal oxidations of drugs were compared using phencyclidine. In general, the chemical reaction systems produced many oxidation products. Besides the formation of the cyclohexane-4-hydroxyl compound (2), hydroxylation of the aromatic ring was favored in the Fenton reaction system (Fe2++H2O2). Formation of an m-hydroxylated product (m-5) was the main aromatic oxidation pathway in the Udenfriend reaction (Fe2+-ascorbic acid-O2), and 2, the piperidine-3-hydroxyl compound (3), and the piperidine-4-hydroxyl compound (4) were also formed. In the system using meso-tetraphenylporphinatoiron chloride (Fe(III)TPPC1) with an oxidant, the main product was the piperidine-3-oxo compound (8). In the liver microsomes system, 2, 4, 8, and m-5, which were all generated by the chemical oxidation reactions, were detected as metabolites of phencyclidine. They were formed by cytochrome P450-dependent reactions. Chemical oxidation systems can be used to study drug metabolism; they can reveal some tendencies of the real metabolis reactions, are easy to operate, and yield sufficient amounts of product.

  使用苯环利定比较了细胞色素P450模型和肝微粒体的药物氧化。一般来说，化学反应系统产生了许多氧化产物。除了形成环己烷-4-羟基化合物（2）外，在芬顿反应体系（Fe2++H2O2）中芳香环的羟基化反应被优先生成。在尤登友反应（Fe2+-抗坏血酸-O2）中，形成m-羟基化产物（m-5）是主要的芳香氧化途径，同时也形成了化合物2、哌啶-3-羟基化合物（3）和哌啶-4-羟基化合物（4）。在使用含氧化剂的美索-四苯基卟啉铁氯化物（Fe(III)TPPC1）体系中，主要产物是哌啶-3-氧化物（8）。在肝微粒体系统中，2、4、8和m-5都是通过化学氧化反应生成的苯环利定代谢物，它们是通过细胞色素P450依赖的反应形成的。化学氧化系统可用于研究药物代谢；它们能够揭示一些真实代谢反应的趋势，操作简单，并能产生足够的产物。
• Phencyclidine and phencyclidine metabolites assay, tracers, immunogens, antibodies and reagent kit
  申请人：ABBOTT LABORATORIES

  公开号：EP0459387A2

  公开（公告）日：1991-12-04

  The present invention is directed to a fluorescence polarization assay for phencyclidine and phencyclidine derivatives, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for making them, and a reagent kit containing them. The tracers and the immunogens are made from substituted phencyclidine compounds. A fluorescein moiety is included in the tracer, while a poly(amino acid) forms a part of the immunogen. The assay is conducted by measuring the degree of polarization retention of plane polarized light that has been passed through a sample containing antiserum and tracer.

  本发明涉及苯环利定和苯环利定衍生物的荧光偏振测定法、制备和进行这种测定法所需的各种成分以及制造这些成分的方法。具体而言，本发明公开了示踪剂、免疫原和抗体，以及制造它们的方法和含有它们的试剂盒。示踪剂和免疫原由取代的苯环利定化合物制成。示踪剂中含有荧光素分子，而免疫原中含有聚氨基酸分子。检测方法是测量通过含有抗血清和示踪剂的样品的平面偏振光的偏振保留程度。
• Methods of characterizing a urine sample
  申请人：Genotox Laboratories

  公开号：US10451544B2

  公开（公告）日：2019-10-22

  This disclosure relates to methods of characterizing a urine sample from a subject.

  本公开涉及鉴定受试者尿样特征的方法。
• Dual swab fluid sample collection for split sample testing and fingerprint identification device
  申请人：Guirguis Raouf A

  公开号：US10564155B2

  公开（公告）日：2020-02-18

  An apparatus for testing a fluid sample including a sample receiving member having an opening for receiving a fluid sample, wherein the sample receiving member comprises at least a first and second sample collection chambers, a sample retention member, in fluid communication with the first sample collection chamber, to retain a portion of the fluid sample, and at least one test strip, in fluid communication with the second collection chamber, to indicate the presence or absence of at least one analyte in the fluid sample, wherein the first collection chamber is not in fluid communication with the second collection chamber.

  一种用于检测流体样品的仪器，包括一个样品接收部件，该部件具有一个用于接收流体样品的开口，其中样品接收部件包括至少一个第一和第二样品收集室、一个与第一样品收集室流体相通的用于保留部分流体样品的样品保留部件，以及至少一个与第二收集室流体相通的用于指示流体样品中是否存在至少一种分析物的测试条，其中第一收集室不与第二收集室流体相通。
• An efficient synthesis of 1-phenyl-1-piperidino-trans-4-methylcyclohexane: Unanticipated total stereoselectivity in the catalytic hydrogenation of an olefin
  作者：F.J. Vinick、J. Nowakowska、S. Jung

  DOI：10.1016/s0040-4039(01)80977-1

  日期：1987.1