3-[4-(3-氧代丙基氨基)丁基氨基]丙醛 | 2578-88-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-[4-(3-氧代丙基氨基)丁基氨基]丙醛
• 英文名称: Spermine dialdehyde
• 英文别名: 3-[4-(3-oxopropylamino)butylamino]propanal
• CAS: 2578-88-3
• 化学式: C₁₀H₂₀N₂O₂
• 分子量: 200.281
• InChiKey: WPBJCXUUUSDQJO-UHFFFAOYSA-N

物化性质

• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  14
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  精胺 、 3-[4-(3-氧代丙基氨基)丁基氨基]丙醛 生成
  参考文献：
  名称：

  Oxidation of di- and polyamines: in vitro effect of amino aldehydes on the vitality of Leishmania promastigotes

  摘要：

  The aminoaldehydes 4-aminobutanal and 5-aminopentanal, derived from the oxidation of the diamines putrescine and cadaverine, and 1-(3-aminopropyl)-4-aminobutanal and aminodialdehyde, derived from the oxidation of the polyamines spermidine and spermine, were produced utilizing a copper amine oxidase (CAO) from Euphorbia characias latex and tested with in vitro cultivation of Leishmania infantum promastigotes. Whereas the aminoaldehydes derived from the oxidation of the diamines were stimulating factors for growth of Leishmania infantum promastigotes, the aldehydes derived from polyamines oxidation had a drastic inhibitory effect on the vitality and growth of these parasites. Thus, a double scenario arises, showing the use of aldehydes from diamines to obtain a large number of organisms of Leishmania infantum promastigotes to use in serological studies, whereas the aldehydes derived from polyamines could be used as a new strategy for therapeutic treatment against these parasites.

  DOI：

  10.1007/s00044-009-9173-0
• 作为产物：
  描述：

  精胺 在 copper amine oxidase 作用下， 反应 0.5h， 生成 3-[4-(3-氧代丙基氨基)丁基氨基]丙醛
  参考文献：
  名称：

  Oxidation of di- and polyamines: in vitro effect of amino aldehydes on the vitality of Leishmania promastigotes

  摘要：

  The aminoaldehydes 4-aminobutanal and 5-aminopentanal, derived from the oxidation of the diamines putrescine and cadaverine, and 1-(3-aminopropyl)-4-aminobutanal and aminodialdehyde, derived from the oxidation of the polyamines spermidine and spermine, were produced utilizing a copper amine oxidase (CAO) from Euphorbia characias latex and tested with in vitro cultivation of Leishmania infantum promastigotes. Whereas the aminoaldehydes derived from the oxidation of the diamines were stimulating factors for growth of Leishmania infantum promastigotes, the aldehydes derived from polyamines oxidation had a drastic inhibitory effect on the vitality and growth of these parasites. Thus, a double scenario arises, showing the use of aldehydes from diamines to obtain a large number of organisms of Leishmania infantum promastigotes to use in serological studies, whereas the aldehydes derived from polyamines could be used as a new strategy for therapeutic treatment against these parasites.

  DOI：

  10.1007/s00044-009-9173-0

文献信息

• Synthesis and antitumor evaluation of the presumed cytotoxic metabolites of spermine and N,N'-bis(3-aminopropyl)nonane-1,9-diamine
  作者：Mervyn Israel、Estelle C. Zoll、Naseem Muhammad、Edward J. Modest

  DOI：10.1021/jm00259a001

  日期：1973.1