mannose triflate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: mannose triflate
• 英文别名: [(2S,3S,4R,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl] trifluoromethanesulfonate
• 化学式: C₇H₁₁F₃O₈S
• 分子量: 312.221
• InChiKey: ZRVBETDBTSLGRE-KVTDHHQDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  150
• 氢给体数：
  4
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  mannose triflate 在 K 2.2.2 、 potassium carbonate 、 氢氟酸 作用下， 以 乙腈 为溶剂， 反应 0.08h， 生成 2-脱氧-2-(18F)氟葡萄糖
  参考文献：
  名称：

  Gomzina, N. A.; Zaitsev, V. V.; Krasikova, R. N., Journal of Labelled Compounds and Radiopharmaceuticals, 2001, vol. 44, p. S895 - S897

  摘要：

  DOI：

文献信息

• Sulfinyl hexose derivatives useful for glycosylation
  申请人：The Trustees of Princeton University

  公开号：US06040433A1

  公开（公告）日：2000-03-21

  Hexose derivatives are described which facilitate control over the stereochemistry of the glycosyl bond formed in the course of a solid phase glycosylation reaction. Methods for their use are also described.

  描述了一种帮助控制固相糖基化反应过程中形成的糖苷键立体化学的己糖衍生物。还描述了它们的使用方法。
• [EN] RADIOFLUORINATION METHOD<br/>[FR] PROCÉDÉ DE RADIOFLUORINATION
  申请人：UNIV DENMARK TECH DTU

  公开号：WO2014020035A1

  公开（公告）日：2014-02-06

  A method of conducting radiofluorination of a substrate, comprising the steps of: (a) contacting an aqueous solution of [18F] fluoride with a polymer supported phosphazene base for sufficient time for trapping of [18F] fluoride on the polymer supported phosphazene base; and (b) contacting a solution of the substrate with the polymer supported phosphazene base having [18F] fluoride trapped thereon obtained in step (a) for sufficient time for a radiofluorination reaction to take place; an apparatus for conducting radiofluorination; use of the apparatus; and an apparatus for production of a dose of a radiotracer for administration to a patient.

  一种进行底物的放射氟化方法，包括以下步骤：(a)将[18F]氟化物的水溶液与聚合物支撑的磷氮烷碱接触足够长的时间，以使[18F]氟化物被捕集在聚合物支撑的磷氮烷碱上；以及(b)将底物的溶液与在步骤(a)中获得的具有[18F]氟化物被捕集在上面的聚合物支撑的磷氮烷碱接触足够长的时间，以进行放射氟化反应；用于进行放射氟化的装置；使用该装置；以及用于生产用于给患者使用的放射示踪剂剂量的装置。
• Microfluidic apparatus and method for synthesis of molecular imaging probes including FDG
  申请人：Buchanan Russell Charles

  公开号：US20050232861A1

  公开（公告）日：2005-10-20

  The invention provides a method and apparatus for preparation of radiochemicals wherein the reaction that couples the radioactive isotope to the reactive precursor to form a positron-emitting molecular imaging probe is performed in a microfluidic environment. The method comprises: providing a micro reactor; introducing a liquid reactive precursor dissolved in a polar aprotic solvent into an inlet port of the micro reactor, the reactive precursor adapted for reaction with a radioactive isotope to form a radiochemical; introducing a solution comprising a radioactive isotope dissolved in a polar aprotic solvent into another inlet port of the micro reactor; contacting the reactive precursor with the isotope-containing solution in a microchannel of the micro reactor; reacting the reactive precursor with the isotope-containing solution as the reactive precursor and isotope-containing solution flow through the microchannel of the micro reactor, wherein the reacting step is conducted at a temperature above the boiling point of the polar aprotic solvent at 1 atm and at a pressure sufficient to maintain the polar aprotic solvent in liquid form; and collecting the resulting radiochemical from the micro reactor.

  该发明提供了一种用于制备放射化学品的方法和装置，其中将将放射性同位素与反应前体耦合以形成正电子发射分子成像探针的反应在微流体环境中进行。该方法包括：提供微反应器；将溶解在极性无水溶剂中的液态反应前体引入微反应器的入口端口，所述反应前体适用于与放射性同位素反应以形成放射化学品；将包含放射性同位素的溶液溶解在极性无水溶剂中的溶液引入微反应器的另一个入口端口；在微反应器的微通道中将反应前体与含同位素的溶液接触；当反应前体和含同位素的溶液通过微反应器的微通道流动时，将反应前体与含同位素的溶液反应，其中反应步骤在1大气压下的极性无水溶剂的沸点以上的温度和足以维持极性无水溶剂处于液态的压力下进行；并从微反应器中收集所得的放射化学品。
• Fluorinated carbohydrate conjugates
  申请人：McBride J. William

  公开号：US20050136001A1

  公开（公告）日：2005-06-23

  Disclosed are novel conjugates that include fluorinated carbohydrate molecules and methods for synthesizing the conjugates. The fluorinated carbohydrate molecule may include a radioisotope. The method of synthesizing the conjugate is useful for labeling selected molecules, and the conjugates may be useful in diagnostic or therapeutic methods. Particularly, the conjugates may be useful in diagnostic or therapeutic kits.

  本文披露了包括氟化碳水化合物分子的新型共轭物以及合成这些共轭物的方法。氟化碳水化合物分子可能包括放射性同位素。合成共轭物的方法可用于标记选择的分子，这些共轭物可能在诊断或治疗方法中有用。特别是，这些共轭物可能在诊断或治疗试剂盒中有用。
• Microfluidic Chemical Reaction Circuits
  申请人：Lee Cheng-Chung

  公开号：US20080281090A1

  公开（公告）日：2008-11-13

  New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.

  提供了用于进行化学反应的新微流体器件。这些器件适用于芯片内的溶剂交换、需要多种化学反应的化学过程以及试剂的快速浓缩。