N-[(Dimethylamino)methylene]-cinnamamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: N-[(Dimethylamino)methylene]-cinnamamide
• 英文别名: N-(dimethylaminomethylidene)-3-phenylprop-2-enamide
• 化学式: C₁₂H₁₄N₂O
• 分子量: 202.256
• InChiKey: VAVFKJNLIHGGJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-[(Dimethylamino)methylene]-cinnamamide 在 1-丙基磷酸酐 作用下， 以 乙酸乙酯 为溶剂， 反应 12.0h， 以92%的产率得到N-formylcinnamamide
  参考文献：
  名称：

  An efficient method for the preparation of N-formyl-imide via amidine using propylphosphonic anhydride (T3P®)

  摘要：

  An efficient method for the preparation of N-formyl imide via amidine using propylphosphonic anhydride (T3P (R)) has been described. Using this method many aryl, hetero aryl, alkyl as well as amino acid imides were synthesized in high yields. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.12.046
• 作为产物：
  描述：

  N,N-二甲基甲酰胺二甲基缩醛 、 肉桂酰胺 以 甲苯 为溶剂， 反应 12.0h， 生成 N-[(Dimethylamino)methylene]-cinnamamide
  参考文献：
  名称：

  An efficient method for the preparation of N-formyl-imide via amidine using propylphosphonic anhydride (T3P®)

  摘要：

  An efficient method for the preparation of N-formyl imide via amidine using propylphosphonic anhydride (T3P (R)) has been described. Using this method many aryl, hetero aryl, alkyl as well as amino acid imides were synthesized in high yields. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.12.046

文献信息

• Methods of modulating processes mediated by excitatory amino acid receptors
  申请人：Cosford Nicholas D. P.

  公开号：US06956049B1

  公开（公告）日：2005-10-18

  In accordance with the present invention, there are provided methods of modulating the activity of excitatory amino acid receptors using a specifically defined class of heterocyclic compounds. In one embodiment, there are provided methods of modulating metabotropic glutamate receptors. The present invention also discloses methods of treating disease using heterocyclic compounds. Diseases contemplated include cerebral ischemia, chronic neurodegeneration, psychiatric disorders, schizophrenia, mood disorders, emotion disorders, disorders of extrapyramidal motor function, obesity, disorders of respiration, motor control and function, attention deficit disorders, concentration disorders, pain disorders, neurodegenerative disorders, epilepsy, convulsive disorders, eating disorders, sleep disorders, sexual disorders, circadian disorders, drug withdrawal, drug addiction, compulsive disorders, anxiety, panic disorders, depressive disorders, skin disorders, retinal ischemia, retinal degeneration, glaucoma, disorders associated with organ transplantation, asthma, ischemia and astrocytomas. The invention further discloses methods of preventing disease conditions related to diseases of the pulmonary system, diseases of the nervous system, diseases of the cardiovascular system, diseases of the gastrointestinal system, diseases of the endocrine system, diseases of the exocrine system, diseases of the skin, cancer and diseases of the ophthalmic system. The invention also discloses pharmaceutically acceptable salt forms of heterocyclic compounds.

  根据本发明，提供了使用一类特定定义的杂环化合物来调节兴奋性氨基酸受体活性的方法。在一种实施例中，提供了调节代谢型谷氨酸受体的方法。本发明还揭示了使用杂环化合物治疗疾病的方法。所考虑的疾病包括脑缺血、慢性神经退行性疾病、精神障碍、精神分裂症、情绪障碍、运动功能外围疾病、肥胖症、呼吸、运动控制和功能障碍、注意力缺陷障碍、注意力障碍、疼痛障碍、神经退行性疾病、癫痫、惊厥性障碍、进食障碍、睡眠障碍、性障碍、昼夜节律障碍、药物戒断、药物成瘾、强迫障碍、焦虑、恐慌障碍、抑郁障碍、皮肤疾病、视网膜缺血、视网膜退化、青光眼、与器官移植相关的疾病、哮喘、缺血和星形细胞瘤。本发明还揭示了杂环化合物的药物可接受的盐形式的方法。
• An efficient method for the preparation of N-formyl-imide via amidine using propylphosphonic anhydride (T3P®)
  作者：M. Sambaiah、Ramakrishna Gudipati、K. Shiva Kumar、Satyanarayana Yennam、Manoranjan Behera

  DOI：10.1016/j.tetlet.2015.12.046

  日期：2016.1

  An efficient method for the preparation of N-formyl imide via amidine using propylphosphonic anhydride (T3P (R)) has been described. Using this method many aryl, hetero aryl, alkyl as well as amino acid imides were synthesized in high yields. (C) 2015 Elsevier Ltd. All rights reserved.