1-Ethoxycyclohexa-1,3-diene | 83443-35-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Ethoxycyclohexa-1,3-diene
• 英文别名: 1-ethoxy-1,3-cyclohexadiene
• CAS: 83443-35-0
• 化学式: C₈H₁₂O
• 分子量: 124.183
• InChiKey: OTAIOQQPWJKNSK-UHFFFAOYSA-N

物化性质

• 沸点：
  195.8±19.0 °C(Predicted)
• 密度：
  0.92±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-chloro-1-phenyl-ethanone oxime 、 1-Ethoxycyclohexa-1,3-diene 在 sodium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以49.2%的产率得到7-ethoxy-3-phenyl-4a,5,6,8a-tetrahydro-4H-1,2-benzoxazine
  参考文献：
  名称：

  Iskanderl, George M.; Gulta, Violette S., Journal of the Chemical Society. Perkin transactions I, 1982, # 8, p. 1891 - 1896

  摘要：

  DOI：

文献信息

• Synthesis of cis-3-hexen-1-ol
  申请人：Givaudan Corporation

  公开号：US03962354A1

  公开（公告）日：1976-06-08

  There is provided a novel method of preparing the highly desired odorant cis-3-hexen-1-ol from alkyl phenyl ethers. The method comprises Birch reduction of the alkyl phenyl ether, sequentially followed by oxidative ring cleavage and reduction.

  提供了一种新颖的制备高度期望的香味物质顺式-3-己烯-1-醇的方法，该方法包括对烷基苯醚进行伯胺还原，然后顺序进行氧化环裂解和还原。
• Perkin communications. Stereochemistry of substituted 1-alkoxybicyclo[2.2.2]octenes; Diels–Alder synthesis versus Tandem-Michael strategy
  作者：John H. Bateson、Carol F. Smith、J. Bruce Wilkinson

  DOI：10.1039/p19910000651

  日期：——

  Diels-Alder reactions of 1-methoxy- and 1 -ethoxy-cyclohexa-1,3-?? dienes with ethyl cinnamate or ethyl 4,4,4-trifluorocrotonate favour the (1RS,2RS,3SR,4RS) (exo-carboxylate) bicyclo[2.2.2]octene stereochemistry, 5,6,9, whereas the bicyclo-octenes derived from 3-alkoxycyclohex-2-enones by Tandem-Michael additions are obtained exclusively as the (1RS,2SR,3RS,4RS) (endo-carboxylate) isomers 16.
• ISKANDERL, G. M.;GULTA, V. S., J. CHEM. SOC. PERKIN TRANS., 1982, N 8, 1891-1895
  作者：ISKANDERL, G. M.、GULTA, V. S.

  DOI：——

  日期：——
• Pyrrolidine Melanocortin-Specific Compounds
  申请人：Sharma D. Shubh

  公开号：US20070155670A1

  公开（公告）日：2007-07-05

  Melanocortin receptor-specific pyrrolidine compounds having the structure: and stereoisomer and pharmaceutically acceptable salts thereof, where R 1 , R 2 , and R 3 are as described in the specification, preferably where R 3 is a D-amino acid with at least one substituted or unsubstituted phenyl or naphthyl aromatic ring, and where R 3 optionally further includes an amine capping group or from one to three additional amino acid residues, optionally with an amine capping group, which compounds are agonists, antagonists or mixed agonists and antagonists at one or more melanocortin receptors, and having utility in the treatment of melanocortin receptor-related disorders and conditions. Methods of synthesis of compounds of structure (I), pharmaceutical compositions containing a compound of structure (I) and methods relating to the use thereof are also disclosed.
• Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections
  申请人：Hedstrom Lizbeth K.

  公开号：US20120264760A1

  公开（公告）日：2012-10-18

  One aspect of the present invention relates to compounds, and pharmaceutically acceptable salts and prodrugs thereof, that are useful as inhibitors of IMPDH. The invention also provides pharmaceutical compositions comprising the compounds of the invention which selectively inhibit parasitic IMPDH. In certain embodiments, the present invention relates to selective inhibition of C. parvum inosine-5′-monophosphate-dehydrogenase over human inosine-5′-monophosphate-dehydrogenase (IMPDH type I and type II). These compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.