5-[(7-氯-4-喹啉基)氨基]-2-[(二乙基氨基)甲基]苯酚 | 1643-45-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 5-[(7-氯-4-喹啉基)氨基]-2-[(二乙基氨基)甲基]苯酚
• 英文名称: Isoquine
• 英文别名: 5-((7-chloroquinolin-4-yl)amino)-2-((diethylamino)methyl)phenol；amodiaquine；5-(7-chloro-[4]quinolylamino)-2-diethylaminomethyl-phenol；5-(7-Chlor-[4]chinolylamino)-2-diaethylaminomethyl-phenol；5-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol
• CAS: 1643-45-4
• 化学式: C₂₀H₂₂ClN₃O
• 分子量: 355.867
• InChiKey: QGFYFOHMBDMGBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  48.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(4-((diethylamino)methyl)-3-hydroxyphenyl)acetamide 在 盐酸 作用下， 生成 5-[(7-氯-4-喹啉基)氨基]-2-[(二乙基氨基)甲基]苯酚
  参考文献：
  名称：

  氨基烷基酚作为抗疟药（杂环氨基）-α-氨基-邻甲酚；迷彩的合成。

  摘要：

  DOI：

  10.1021/ja01184a023

文献信息

• [EN] 4-AMINOQUINOLINE COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS<br/>[FR] COMPOSÉS DE 4-AMINOQUINOLINE POUR LE TRAITEMENT DE L'ANGIOGENÈSE
  申请人：SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST

  公开号：WO2019173482A1

  公开（公告）日：2019-09-12

  Described herein is the use of 4-aminoquinoline compounds as inhibitors of angiogenesis, such as retinal pathological angiogensis. Also described herein are compositions and formulations comprising such compounds for the use in treatment of pathological angiogenesis.

  本文描述了4-氨基喹啉化合物作为抑制血管生成的用途，例如视网膜病理性血管生成。本文还描述了包含这些化合物的组合物和配方，用于治疗病理性血管生成。
• [EN] ANTI-MALARIAL COMPOUNDS<br/>[FR] COMPOSES ANTI-MALARIA
  申请人：UNIV LIVERPOOL

  公开号：WO2002072554A1

  公开（公告）日：2002-09-19

  The present invention relates to pharmaceutical compounds for use in the treatment or porphylaxis of malaria having the general formula: where: R is selected from the group consisting of dimethylamino, diethylamino, di-N-propylamino, diisopropylamino, di-N-butylamino, di-sec-butylamino, piperidinyl, piperizinyl, ethylamino, tert-butylamino; and X is selected from the group consisting of chloro, fluoro, iodo, bromo, trifluoromethyl, methoxy and methyl.

  本发明涉及一种用于治疗或预防疟疾的药物化合物，其通式为：其中：R选自二甲氨基，二乙氨基，二-N-丙基氨基，二异丙基氨基，二-N-丁基氨基，二-sec-丁基氨基，哌啶基，哌嗪基，乙基氨基，叔丁基氨基等组成的群体；X选自氯，氟，碘，溴，三氟甲基，甲氧基和甲基等组成的群体。
• Anti-malarial compounds
  申请人：——

  公开号：US20040152729A1

  公开（公告）日：2004-08-05

  The present invention relates to pharmaceutical compounds for use in the treatment or porphylaxis of malaria having the general formula: where: R is selected from the group consisting of dimethylamino, diethylamino, di-N-propylamino, diisopropylamino, di-N-butylamino, di-sec-butylamino, piperidinyl, piperizinyl, ethylamino, tert-butylamino; and X is selected from the group consisting of chloro, fluoro, iodo, bromo, trifluoromethyl, methoxy and methyl. 1

  本发明涉及用于治疗或预防疟疾的药物化合物，其一般公式为：其中：R选自二甲氨基，二乙氨基，二-N-丙基氨基，二异丙基氨基，二-N-丁基氨基，二-sec-丁基氨基，哌啶基，哌嗪基，乙基氨基，叔丁基氨基等组成的群体；X选自氯，氟，碘，溴，三氟甲基，甲氧基和甲基等组成的群体。
• ANTI-MALARIAL COMPOUNDS
  申请人：THE UNIVERSITY OF LIVERPOOL

  公开号：EP1368321A1

  公开（公告）日：2003-12-10
• QUINOLINE COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF
  申请人：Orlow Seth J.

  公开号：US20090298868A1

  公开（公告）日：2009-12-03

  A method of identification of quinoline compounds (formula I) that modify melanin synthesis (melanogenesis), and the use of such compounds and compositions thereof to control (e.g., inhibit) melanin production are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant melanogenesis activity including by way of non-limiting example, pigmentation deficiencies (albinism) and hyperpigmentation and others.