N-(9-吖啶基)-N'-[3-(9-吖啶基氨基)丙基]-1,1-丁烷二胺 | 58478-34-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: N-(9-吖啶基)-N'-[3-(9-吖啶基氨基)丙基]-1,1-丁烷二胺
• 英文名称: N-<3-(9-acridinylamino)propyl>-N-<4-(9-acridinylamino)butyl>amine
• 英文别名: Spermidine-Diacridine；4-[(Acridin-9(10H)-ylidene)amino]-N-{3-[(acridin-9(10H)-ylidene)amino]propyl}butan-1-amine；N'-acridin-9-yl-N-[3-(acridin-9-ylamino)propyl]butane-1,4-diamine
• CAS: 58478-34-5
• 化学式: C₃₃H₃₃N₅
• 分子量: 499.659
• InChiKey: LWQBIDWWCLPUBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  38
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  61.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  9-氯吖啶 、 亚精胺 在 苯酚 作用下， 反应 3.5h， 生成 N-(9-吖啶基)-N'-[3-(9-吖啶基氨基)丙基]-1,1-丁烷二胺
  参考文献：
  名称：

  Multisignal labeling reagents and processes and uses therefor

  摘要：

  提供的是由连接基团共价连接的两个DNA超分子结合分子组成的化合物。还提供了多信号标记试剂，包括（i）核苷酸或核苷酸类似物的寡聚物；（ii）非共价结合于寡聚物的DNA超分子结合分子；以及（iii）共价结合于寡聚物的第一反应性基团或第一结合对的第一配对体。此外还提供了制备多信号标记试剂的方法。

  公开号：

  US09156986B2

文献信息

• Potential antitumor agents. 44. Synthesis and antitumor activity of new classes of diacridines: importance of linker chain rigidity for DNA binding kinetics and biological activity
  作者：William A. Denny、Graham J. Atwell、Bruce C. Baguley、Laurence P. G. Wakelin

  DOI：10.1021/jm00149a005

  日期：1985.11

  Four classes of diacridines, joined at the 9-position by linker chains of varying length, rigidity, and polarity, were evaluated for DNA-binding properties and antitumor activity. Diacridines linked by flexible chains of varying polarity show relatively fast chromophore exchange kinetics among DNA binding sites but slower dissociation rates, suggesting the potential for considerable "creeping" of the drug along the helix, and are inactive in vivo. The exchange kinetics can be slowed dramatically by inclusion of positive charges in the side chain, but the resulting polycationic drugs are inactive in vivo, possibly due to poor distribution. Diacridines linked by a rigid, polar but neutral dicarbamoylpyrazole chain retain slow exchange kinetics, have a greatly reduced potential "creep rate", and possess good in vitro potency and significant in vivo antileukemic activity.
• DENNY, W. A.;ATWELL, G. J.;BAGULEY, B. C.;WAKALIN, L. P. G., J. MED. CHEM., 1985, 28, N 11, 1568-1574
  作者：DENNY, W. A.、ATWELL, G. J.、BAGULEY, B. C.、WAKALIN, L. P. G.

  DOI：——

  日期：——
• MULTISIGNAL LABELING REAGENTS AND PROCESSES AND USES THEREFOR
  申请人：Enzo Life Science, Inc., c/o Enzo Biochem, Inc.

  公开号：US20160025716A1

  公开（公告）日：2016-01-28

  Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.
• US5990089A
  申请人：——

  公开号：US5990089A

  公开（公告）日：1999-11-23
• US6113946A
  申请人：——

  公开号：US6113946A

  公开（公告）日：2000-09-05