2-(3,4-dichlorophenyl)-5-nitroquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(3,4-dichlorophenyl)-5-nitroquinoline
• 英文别名: 2-(3,4-Dichlorophenyl)-5-nitroquinoline
• 化学式: C₁₅H₈Cl₂N₂O₂
• 分子量: 319.147
• InChiKey: YYXJZYMHQZOPCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-硝基喹啉 、 邻二氯苯 在 氧气 、 palladium diacetate 、 silver carbonate 、 三甲基乙酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 150.0 ℃ 、101.33 kPa 条件下， 反应 30.0h， 以71%的产率得到2-(3,4-dichlorophenyl)-5-nitroquinoline
  参考文献：
  名称：

  Palladium-Catalyzed C-2 Selective Arylation of Quinolines

  摘要：

  An efficient method for the Pd-catalyzed regioselective C-2 arylation of quinolines is presented. Reactions of various substituted quinolines and unactivated arenes have been conducted under mild conditions. The result shows good product yields of 2-arylquinolines, which are highly useful building blocks for the synthesis of bioactive alkaloid natural products and drug molecules.

  DOI：

  10.1021/ol402262c

文献信息

• Palladium-Catalyzed C-2 Selective Arylation of Quinolines
  作者：Xiaoyu Ren、Ping Wen、Xiaokang Shi、Yuling Wang、Jian Li、Sizhuo Yang、Hao Yan、Guosheng Huang

  DOI：10.1021/ol402262c

  日期：2013.10.18

  An efficient method for the Pd-catalyzed regioselective C-2 arylation of quinolines is presented. Reactions of various substituted quinolines and unactivated arenes have been conducted under mild conditions. The result shows good product yields of 2-arylquinolines, which are highly useful building blocks for the synthesis of bioactive alkaloid natural products and drug molecules.