三甲基硅烷 | 993-07-7

• 物质功能分类: 化学试剂 - 硅烷试剂
• 分子结构分类: 有机化合物 - 碳氢化合物衍生物
• 中文名称: 三甲基硅烷
• 英文名称: HSiMe3
• 英文别名: trimethylsilan；trimethylsilane
• CAS: 993-07-7
• 化学式: C₃H₁₀Si
• 分子量: 74.1979
• InChiKey: PQDJYEQOELDLCP-UHFFFAOYSA-N

物化性质

• 熔点：
  -135,9°C
• 沸点：
  6,7°C
• 密度：
  0,638 g/cm3
• LogP：
  2.2 at 20℃
• 物理描述：
  GasVapor

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

ADMET

毒理性

• 毒性数据

大鼠LC50 > 5000 ppm/1小时

LC50 (rat) > 5,000 ppm/1hr

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

安全信息

• TSCA：
  Yes
• 安全说明：
  S16,S26,S33,S9
• 危险类别码：
  R36/37/38,R12
• 危险品运输编号：
  UN 3161
• 海关编码：
  2931900090

SDS

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Section 1: Product Identification
Chemical Name: Trimethylsilane, 97%
CAS Registry Number: 993-07-7
Formula: (CH3)3SiH
EINECS Number: 213-603-0
Chemical Family: organosilicon compounds
Synonym: Silane, trimethyl

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Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title Compound 993-07-7 100% no data no data

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Section 3: Hazards Identification
Emergency Overview: May be irritating to skin, eyes, and respiratory tract.
Primary Routes of Exposure: Inhalation, skin, eyes.
Eye Contact: May cause moderate irritation of the eyes.
Skin Contact: May cause slight to mild irritation of the skin.
May cause irritation to the nose, mucous membranes and respiratory tract. May be harmful through inhalation.
Inhalation:
Ingestion: No specific information is available on the physiological effects of ingestion.
Acute Health Affects: May be irritating to skin, eyes and mucous membranes. May be harmful through inhalation.
Chronic Health Affects: No information available on long-term chronic effects.
NTP: No
IARC: No
OSHA: No

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SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

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SECTION 5: Fire Fighting Measures
Flash Point: <-4°F
Autoignition Temperature: no data
Explosion Limits: no data
Extinguishing Medium: carbon dioxide or dry powder
Fire fighters should be equipped with a NIOSH approved positive pressure self-contained breathing apparatus
Special Fire Fighting Procedures:
and full protective clothing.
Hazardous Combustion and Burning material may emit toxic and corrosive fumes.
Decomposion Products:
Unusual Fire or Explosion Hazards: Highly flammable. Material readily ignited with flames, sparks, friction or heat.

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SECTION 6: Accidental Release Measures
The material will evaporate rapidly at room temperature. Leave the area unless fitted with a self-contained
Spill and Leak Procedures: breathing apparatus or until the vapors have dispersed. Larger spills can be absorbed into vermiculite or other
suitable noncombustible adsorbent. Sweep up the material and dispose of properly.

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SECTION 7: Handling and Storage
Handling and Storage: The material is stored in steel cylinder.

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SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection: Wear protective clothing and gloves. Consult with glove manufacturer to determine the proper type of glove.
Ventilation: Handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: Handle the material in an efficient fume hood.
Additional Protection: No additional protection required.

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SECTION 9: Physical and Chemical Properties
Color and Form: gas
Molecular Weight: 74.2
Melting Point: -135.9°
Boiling Point: 6.7°C
Vapor Pressure: no data
Specific Gravity: 0.638 (6.7°)
Odor: not determined
Solubility in Water: insoluble

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SECTION 10: Stability and Reactivity
Stability: air and moisture stable
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: contact with heat or ignition sources.
Incompatibility: Strong oxidizing agents and halogens
Decomposition Products: carbon monoxide, carbon dioxide, silicon dioxide, and organic fumes.

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SECTION 11: Toxicological Information
RTECS Data: No information available in the RTECS files.
Carcinogenic Effects: No data available
Mutagenic Effects: No data available
Tetratogenic Effects: No data available

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SECTION 12: Ecological Information
Ecological Information: No information available

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SECTION 13: Disposal Considerations
Disposal: Dispose of according to federal, state, and local regulations.

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SECTION 14: Transportation
Shipping Name (CFR): Liquefied Gas, Flammable, N.O.S.
Hazard Class (CFR): 2.1
Additional Hazard Class (CFR): NA
Packaging Group (CFR): NA
UN ID Number (CFR): UN# 3161
Shipping Name (IATA): Liquefied Gas, Flammable, N.O.S.
Hazard Class (IATA): 2.1
Additional Hazard Class (IATA): NA
Packaging Group (IATA): NA
UN ID Number (IATA): UN# 3161

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SECTION 15: Regulatory Information
TSCA: Listed in the TSCA inventory.
SARA (Title 313): Title compound not listed.
Second Ingredient: none

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

三甲基硅烷简介

三甲基硅烷或称三甲基硅化氢，是一种有机硅化合物。它极易燃烧，在半导体工业中用作等离子相腐蚀剂。

化学性质

三甲基硅烷是一种无色、具有刺鼻气味的液体，其蒸汽密度大于空气，可能沿地面扩散并引发远处火灾。

用途

近年来，三甲基硅烷在半导体领域的应用日益广泛。它常被用作层间绝缘膜的成膜原料，用途逐渐扩大。

反应信息

• 作为反应物：
  描述：

  三甲基硅烷 在 溴 作用下， 生成 三甲基溴硅烷
  参考文献：
  名称：

  Sliwinski; Mueller, CHEMTECH, 1951, vol. 3, p. 293,295

  摘要：

  DOI：
• 作为产物：
  描述：

  三甲基溴硅烷 在 2,2,6,6-四甲基哌啶 、 氢气 、 tris(2,6-difluorophenyl)borane 作用下， 以 氘代苯 为溶剂， 25.0 ℃ 、1.0 MPa 条件下， 反应 16.0h， 以71%的产率得到三甲基硅烷
  参考文献：
  名称：

  甲硅烷基三氟甲磺酸酯和卤化物无金属催化氢解成氢硅烷**

  摘要：

  甲硅烷基三氟甲磺酸酯和卤化物无金属氢解成氢硅烷的过程被解锁。这是通过使用与金属催化剂竞争的硼基有机催化剂来实现的。

  DOI：

  10.1002/anie.202200911
• 作为试剂：
  描述：

  T406石油添加剂 、 4-硝基苯乙烯 在 dipotassium peroxodisulfate 、 三甲基硅烷 、 二苯基二硒醚 作用下， 以 1,4-二氧六环 为溶剂， 以65%的产率得到2-(1-(4-nitrophenyl)vinyl)-2H-benzo[d][1,2,3]triazole
  参考文献：
  名称：

  烯烃与苯并三唑的有机硒催化的N1-和N2-选择性氮杂-Wacker反应。

  摘要：

  据报道烯烃与苯并三唑的有机硒催化的N1-和N2-选择性氮杂-Wacker反应，可轻松获得N1-和N2-烯化的苯并三唑衍生物。该方法的广泛底物范围，良好的官能团耐受性和简便的放大规模有望促进其在合成化学中的潜在应用。提出了一种初步的机制来解释N1和N2的选择性。

  DOI：

  10.1039/d0cc01079k

文献信息

• ANTI-EGFR ANTIBODY DRUG CONJUGATES
  申请人：AbbVie Inc.

  公开号：US20190153107A1

  公开（公告）日：2019-05-23

  The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods of using said ADCs.

  这项发明涉及抑制Bcl-xL的抗表皮生长因子受体（EGFR）抗体药物结合物（ADCs），包括使用所述ADCs的组合物和方法。
• Efficient Three-Component Strecker Reaction of Acetals and Aromatic Amines Catalysed by Hafnium Tetrachloride at Room Temperature
  作者：Xue-Lin Zhang、Qin-Pei Wu、Qing-Shan Zhang

  DOI：10.3184/174751913x13814077309487

  日期：2013.11

  A straightforward, mild, efficient, one-pot method has been found for the synthesis of α-aminonitriles via three-component Strecker reaction using acetals or cyclic acetals, curious aromatic amines and trimethylsilyl cyanide (TMSCN) catalysed by hafnium tetrachloride at room temperature. It is with good to excellent yields under mild conditions. This developed approach has been successfully applied

  已经找到了一种简单、温和、高效的一锅法，通过三组分 Strecker 反应，使用缩醛或环状缩醛、奇怪的芳香胺和三甲基氰化硅烷 (TMSCN) 在室温下由四氯化铪催化合成 α-氨基腈。它在温和的条件下具有良好的收率。这种开发的方法已成功应用于合成具有多种官能团的各种α-氨基腈。
• [EN] INHIBITORS OF RAF KINASES<br/>[FR] INHIBITEURS DE KINASES RAF
  申请人：KINNATE BIOPHARMA INC

  公开号：WO2020198058A1

  公开（公告）日：2020-10-01

  Provided herein are inhibitors of receptor tyrosine kinase effector, RAF, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

  本文提供了受体酪氨酸激酶效应子RAF的抑制剂，包括所述化合物的药物组合物，以及使用这些化合物治疗疾病的方法。
• The chemistry of tetrakis(trifluoromethyl)cyclopentadienone
  作者：Mark J. Burk、Joseph C. Calabrese、Fredric Davidson、Richard L. Harlow、D. Christopher Roe

  DOI：10.1021/ja00006a045

  日期：1991.3

  Reactivity of tetrakis (trifluoromethyl) cyclopentadienone, which include nucleophilic addition, reaction with proton containing nucleophiles, cyclopropane formation, one-electron reduction leading to a stable radical anion salt and finally chemical reduction with silanes to yield siloxydienes which, upon deprotonation, afford new tetrakis (trifluoromethyl) cyclopentadienyl derivatives

  四（三氟甲基）环戊二烯酮的反应性，包括亲核加成、与含质子亲核试剂的反应、环丙烷的形成、单电子还原导致稳定的自由基阴离子盐，最后用硅烷化学还原生成甲硅烷二烯，在去质子化后，得到新的四甲(三氟甲基)环戊二烯基衍生物
• Lewis Base Catalyzed Selective Chlorination of Monosilanes
  作者：Alexander G. Sturm、Julia I. Schweizer、Lioba Meyer、Tobias Santowski、Norbert Auner、Max C. Holthausen

  DOI：10.1002/chem.201803921

  日期：2018.12.3

  A preparatively facile, highly selective synthesis of bifunctional monosilanes R2SiHCl, RSiHCl2 and RSiH2Cl is reported. By chlorination of R2SiH2 and RSiH3 with concentrated HCl/ether solutions, the stepwise introduction of Si−Cl bonds is readily controlled by temperature and reaction time for a broad range of substrates. In a combined experimental and computational study, we establish a new mode

  据报道，双官能甲硅烷R 2 SiHCl，RSiHCl 2和RSiH 2 Cl的制备容易，选择性高。通过氯化R 2 SiH 2和RSiH 3在浓盐酸/乙醚溶液中，Si-Cl键的逐步引入很容易受温度和反应时间的控制，适用于多种基材。在一项组合的实验和计算研究中，我们建立了一种新的Si-H键激活模式，该模式由路易斯碱（例如醚，胺，膦和氯离子）辅助。对基本反应机理的阐明表明，通过氢键网络的酒精辅助同样有效且具有选择性。值得注意的是，在中等反应条件下未观察到烷氧基硅烷或硅氧烷的形成。

表征谱图