An antibody-drug conjugate (ADC) has a structure represented by Formula (I):
[D
2
-L
2
-Cn
2
y
G
2
-Ab-Sg
1
G
1
-L
1
-D
1
]
x
Formula (I)
or a pharmaceutically acceptable salt thereof, wherein
Ab is an antibody without glycans (i.e., the protein portion of an antibody);
G
1
and G
2
are glycan moieties, which may be the same or different;
Cn
1
and Cn
2
are conjugation moieties, which may be the same or different;
L
1
and L
2
are linker moieties, which may be the same or different;
D
1
and D
2
are drug units which may be the same or different; and
x and y are independently an integer from 0 to 8, provided that x+y≠0.
一种
抗体药物偶联物(ADC)具有以下式(I)所代表的结构:
[D2-
L2-Cn2yG2-Ab-Sg1G1-L1-D1]x
式(I)
或其药用可接受的盐,其中
Ab是没有糖基的
抗体(即
抗体的蛋白质部分);
G1和G2是糖基部分,可以相同也可以不同;
Cn1和Cn2是结合基部分,可以相同也可以不同;
L1和
L2是连接基部分,可以相同也可以不同;
D1和D2是药物单元,可以相同也可以不同;
x和y分别是从0到8的整数,但要求x+y≠0。