(2E,8E)-Deca-2,8-dien-5-yne-4,7-diol | 135468-07-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2E,8E)-Deca-2,8-dien-5-yne-4,7-diol
• 英文别名: deca-2,8-dien-5-yne-4,7-diol；Deca-2,8-dien-5-in-4,7-diol；Dipropenylbutindiol
• CAS: 135468-07-4
• 化学式: C₁₀H₁₄O₂
• 分子量: 166.22
• InChiKey: QUVPYYXBNNSSNY-GGWOSOGESA-N

物化性质

• 沸点：
  271.1±35.0 °C(Predicted)
• 密度：
  1.039±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2E,8E)-Deca-2,8-dien-5-yne-4,7-diol 在 chromium(VI) oxide 、 硫酸 、 丙酮 作用下， 生成 deca-2,8-dien-5-yne-4,7-dione
  参考文献：
  名称：

  15.炔类化合物的研究。第三部分 乙炔基酮中的二烯加成

  摘要：

  DOI：

  10.1039/jr9460000052
• 作为产物：
  描述：

  丁烯-2-醛 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 作用下， 生成 (2E,8E)-Deca-2,8-dien-5-yne-4,7-diol
  参考文献：
  名称：

  Heilbron; Jones; Raphael, Journal of the Chemical Society, 1943, p. 269

  摘要：

  DOI：

文献信息

• Reppe et al., Justus Liebigs Annalen der Chemie, 1955, vol. 596, p. 65
  作者：Reppe et al.

  DOI：——

  日期：——
• Investigation of a Mechanism for Accelerated Breakdown of Immune Tolerance to the Primary Biliary Cirrhosis–Associated Autoantigen, Pyruvate Dehydrogenase Complex
  作者：David E J Jones、Jeremy M Palmer、Kate Bennett、Amanda J Robe、Stephen J Yeaman、Helen Robertson、Margaret F Bassendine、Alastair D Burt、John A Kirby

  DOI：10.1038/labinvest.3780413

  日期：2002.2

  Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by autoreactive T- and B-cell responses to the highly conserved enzyme pyruvate dehydrogenase complex (PDC). In this study we have examined the breakdown of T-cell tolerance to self-PDC using a mouse model. Female SJL/J mice were sensitized intraperitoneally with foreign-PDC (bovine) and/or self-PDC (murine) in complete Freund's adjuvant, and serum, spleen, and liver tissue was taken 8 weeks later. Animals sensitized with foreign-PDC produced IgG antibodies that were reactive with both foreign and self-PDC, but splenic T cells from these animals only responded to stimulation with foreign PDC. Sensitization with self-PDC elicited neither antibodies nor reactive T cells. Significantly, cosensitization with mixed self-PDC and foreign-PDC resulted in a full breakdown of self-tolerance, with generation of both antibody and T-cell responses to self-PDC of the type seen exclusively in human PBC patients. Mild bile duct lesions deficient in CD8(+) T cells were seen 8 weeks after sensitization with either foreign or self-PDC. However, after sensitization with mixed self-PDC and foreign-PDC, these lesions were significantly larger and heavily infiltrated by CD8(+) T cells. Liver-infiltrating T cells derived from the self-PDC and foreign-PDC cosensitized but not from control animals showed reactivity with self-PDC, suggesting a possible role for autoreactive PDC-specific T-cell responses in the pathogenesis of the observed histologic changes. It is likely that B-cell cross-reactivity between foreign and self-PDC enhances the potential for breakdown of T-cell self-tolerance by allowing efficient presentation of self-antigens in the inoculum. This model may provide a useful system for investigating the etiology and treatment of PBC.
• Dupont, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1911, vol. 153, p. 275
  作者：Dupont

  DOI：——

  日期：——
• DE726714
  申请人：——

  公开号：——

  公开（公告）日：——
• Heilbron et al., Journal of the Chemical Society, 1945, p. 84,87
  作者：Heilbron et al.

  DOI：——

  日期：——