(2,2-二氯-1-苯乙烯基)苯 | 2779-69-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2,2-二氯-1-苯乙烯基)苯
• 英文名称: 1,1-dichloro-2,2-diphenylethene
• 英文别名: Ethene, 1,1-diphenyl-2,2-dichloro-；(2,2-dichloro-1-phenylethenyl)benzene
• CAS: 2779-69-3
• 化学式: C₁₄H₁₀Cl₂
• 分子量: 249.139
• InChiKey: GVLRAPLHURDGPL-UHFFFAOYSA-N

物化性质

• 保留指数：
  1754

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903999090

反应信息

• 作为反应物：
  描述：

  (2,2-二氯-1-苯乙烯基)苯 在 氢氧化钾 作用下， 生成 2,2-二苯基乙酸
  参考文献：
  名称：

  The Halogenation of Unsymmetrical Diphenylethane¹

  摘要：

  DOI：

  10.1021/ja01861a037
• 作为产物：
  描述：

  苯基乙苯 在 乙醇 、 氯 、 锌 作用下， 生成 (2,2-二氯-1-苯乙烯基)苯
  参考文献：
  名称：

  Li, Nippon Kagaku Kaishi/Journal of the Chemical Society of Japan, 1943, vol. 64, p. 1399,1404

  摘要：

  DOI：

文献信息

• The Influence of Growth Hormone Deficiency, Growth Hormone Replacement Therapy, and Other Aspects of Hypopituitarism on Fracture Rate and Bone Mineral Density
  作者：Christian Wüster、Roger Abs、Bengt-Åke Bengtsson、Helge Bennmarker、Ulla Feldt-Rasmussen、Elizabeth Hernberg-Ståhl、John P. Monson、Bjørn Westberg、Patrick Wilton

  DOI：10.1359/jbmr.2001.16.2.398

  日期：——

  To assess the influence of factors affecting fracture risk and bone density in adult hypopituitary patients with growth hormone deficiency (GHD), data from a large‐scale pharmacoepidemiological survey (the Pharmacia & Upjohn International Metabolic Database [KIMS]) were analyzed and compared with data from a control population (the European Vertebral Osteoporosis Study [EVOS]). The KIMS group consisted of 2084 patients (1112 men and 972 women) with various types of pituitary disease and EVOS consisted of 1176 individuals (581 men and 595 women). Fracture and bone mineral density (BMD) data were available from 2024 patients from the KIMS group and 392 patients from EVOS. The prevalence of fractures in patients with hypopituitarism was 2.66 times that in the non‐GH‐deficient EVOS population. Adult‐onset hypopituitarism with GHD was associated with a higher fracture risk than childhood‐onset disease, and patients with isolated GHD had a similar prevalence of fractures to those with multiple pituitary hormone deficiencies. Hormonal replacement therapy with L‐thyroxine, glucocorticoids, and sex steroids did not affect the risk of fracture in KIMS patients. In addition, fracture rates in KIMS were independent of body mass index (BMI) and the country of origin. However, smoking was associated with a higher fracture rate in this group. In summary, this is the first large‐scale analysis to support the hypothesis of an increased fracture risk in adult patients with hypopituitarism and GHD. This increased risk appears to be attributable to GHD alone, rather than to other pituitary hormone deficiencies or to their replacement therapy.

  为了评估影响成年垂体功能减退症患者骨折风险和骨密度的因素，特别是生长激素缺乏症（GHD）的影响，我们分析了一项大规模药物流行病学调查（法玛西亚与安万特国际代谢数据库[KIMS]）的数据，并与对照人群（欧洲椎骨骨质疏松症研究[EVOS]）的数据进行了比较。KIMS组包括2084名患者（1112名男性和972名女性），他们患有各种类型的垂体疾病，而EVOS组包括1176名个体（581名男性和595名女性）。从KIMS组的2024名患者和EVOS组的392名患者中获得了骨折和骨矿物质密度（BMD）数据。垂体功能减退症患者的骨折发生率是GH非缺乏的EVOS人群的2.66倍。与儿童期发病的疾病相比，成年期发病的垂体功能减退症伴GHD与更高的骨折风险相关，而孤立性GHD患者的骨折发生率与多重垂体激素缺乏症患者的骨折发生率相似。使用L-甲状腺素、糖皮质激素和性激素的激素替代疗法并未影响KIMS患者的骨折风险。此外，KIMS中的骨折率与体重指数（BMI）和原籍国无关。然而，吸烟与该组较高的骨折率相关。总之，这是首次大规模分析支持成年垂体功能减退症和GHD患者骨折风险增加的假设。这种增加的风险似乎仅归因于GHD，而非其他垂体激素缺乏或其替代疗法。
• Kinetic and quantum chemical studies of the mechanism of dehydrochlorination of 2,2-diaryl-1,1,1-trichloroethanes with nitrite ions
  作者：V. N. Kazin、M. B. Kuzhin、A. V. Sirik、E. A. Guzov

  DOI：10.1134/s1070428016090049

  日期：2016.9

  The E2 mechanism has been proposed for the dehydrochlorination of 2,2-diaryl-1,1,1-trichloroethanes with nitrite ion, leading to 2,2-diaryl-1,1-dichloroethenes, on the basis of experimental kinetic study and quantum chemical simulation.

  在实验动力学研究和量子力学的基础上，提出了利用亚硝酸根离子将2,2-二芳基-1,1,1-三氯乙烷脱氯化氢，生成2,2-二芳基-1,1-二氯乙烯的E2机理。化学模拟。
• Photocycloelimination of α,α-dichlorocyclobutanones
  作者：Jailall Ramnauth、Edward Lee-Ruff

  DOI：10.1139/v99-110

  日期：1999.7.1

  Direct irradiation of a series of α,α-dichlorocyclobutanones in benzene solutions results in photocycloelimination to give 1,1-dichloroalkenes in yields ranging from 30-65%. The α,α-dichlorocyclobutanones were formed in good yields from the [2+2] cycloaddition of the terminal olefins with dichloroketene. This two-step sequence formally represents a "metathesis" of two olefinic functions and provides an easy access to functionalized 1,1-dichloroalkenes. Irradiation of the dichlorocyclobutanones in the solid state led to poor yields of 1,1-dichloroalkenes and polymeric mixtures, however, photoreactions performed in zeolites gave similar yields as those run in benzene solutions.Key words: dichlorocyclobutanones, dichloroalkenes, olefin metathesis, photocycloelimination.

  在苯溶液中直接照射一系列α,α-二氯环丁酮会发生光环丁烯消除反应，产生收率在30-65%之间的1,1-二氯烯。α,α-二氯环丁酮是通过末端烯烃与二氯酮烯的[2+2]环加成反应高收率形成的。这个两步反应序列形式上代表了两个烯烃功能的“转化”，并提供了一种易于获得官能化1,1-二氯烯的途径。在固态中照射二氯环丁酮会导致1,1-二氯烯和聚合物混合物的收率较低，然而，在沸石中进行的光反应与在苯溶液中进行的反应产生了类似的收率。关键词：二氯环丁酮，二氯烯，烯烃转化，光环丁烯消除。
• Synthesis of annulated oligothiophenes
  作者：V. G. Nenajdenko、E. S. Balenkova、K. Y. Chernichenko、S. S. Vshivenko

  DOI：10.1007/s11172-012-0188-1

  日期：2012.7

  Reactions of 1,1-di(2-naphthyl)-2,2-dichloroethene and 1,1-di(2-benzothienyl)-2,2-dichloroethene with sulfur at 220–225 °C resulted in hitherto unknown oligothiophenes. Tetrathio[6]helicene was synthesized from 1,1-di(3-benzothienyl)-2,2-dichloroethene. Preparative pathway to helicene involving intramolecular ring closure of dithiol derived from 1,1-di-(3-benzothienyl)-2,2-dichloroethene was developed as an alternative to high temperature synthesis.

  1,1-二（2-萘基）-2,2-二氯乙烯和1,1-二（2-苯并噻烷基）-2,2-二氯乙烯与硫在220-225°C下反应生成了迄今为止未知的寡硫烯。四硫[6]螺旋烯是由1,1-二（3-苯并噻烷基）-2,2-二氯乙烯合成的。开发了一条合成螺旋烯的新路径，该路径涉及从1,1-二（3-苯并噻烷基）-2,2-二氯乙烯衍生的二硫醇的分子内环闭合，作为高温合成的替代方案。
• Ramberg-Bäcklund rearrangement vs. β-Elimination of haloform from trichloro and trifluoromethyl sulfones
  作者：Samuel Braverman、Yossi Zafrani

  DOI：10.1016/s0040-4020(97)10404-5

  日期：1998.2

  A new and convenient method for the preparation of trichloro and trifluoromethanesulfinates is described. These esters readily undergo rearrangement to the corresponding sulfones at room temperature, in high yields. In contrast to trichloromethyl sulfoxides which undergo base-induced β-elimination of chloroform to sulfines, the corresponding sulfones undergo an unusually facile Ramberg-Bäcklund rearrangement

  描述了一种新的方便的制备三氯和三氟甲烷亚磺酸盐的方法。这些酯在室温下容易以高产率重排成相应的砜。与三氯甲基亚砜经历碱诱导的氯仿的β-消除作用成亚砜相反，相应的砜经历了异常容易的Ramberg-Bäcklund重排并形成了二氯亚甲基产物。即使在剧烈的碱性条件下，用CF 3代替CCl 3也会导致反应性完全丧失。

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