1-bromo-4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene | 125808-05-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-bromo-4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene
• 英文别名: 1-Bromo-4-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzene；1-bromo-4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]benzene
• CAS: 125808-05-1
• 化学式: C₁₃H₁₉BrO₄
• mdl: MFCD26319147
• 分子量: 319.195
• InChiKey: XYMRNKPBIQIHHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-bromo-4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene 在 正丁基锂 作用下， 以 乙醚 、 二甲基亚砜 为溶剂， 反应 9.0h， 生成
  参考文献：
  名称：

  Staudinger-Phosphonite Reactions for the Chemoselective Transformation of Azido-Containing Peptides and Proteins

  摘要：

  Site-specific functionalization of proteins by bloorthogonal modification offers a convenient pathway to create, modify, and study biologically active biopolymers. In this paper the Staudinger reaction of aryl-phosphonites for the chemoselective functionalization of azido-peptides and proteins was probed. Different water-soluble phosphonites with ollgoethylene substituents were synthesized and reacted with unprotected azido-containing peptides in aqueous systems at room temperature in high conversions. Finally, the Staudinger-phosphonite reaction was successfully applied to the site-specific modification of the protein calmodulin.

  DOI：

  10.1021/ol2020175
• 作为产物：
  描述：

  2-(2-苯氧基乙氧基)乙醇 在 氢氧化钾 、 溴 、 十六烷基三甲基溴化铵 、 sodium 、 三溴化磷 作用下， 以 吡啶 、 甲醇 、 水 为溶剂， 反应 52.0h， 生成 1-bromo-4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene
  参考文献：
  名称：

  Selective bromination of the aromatic ring in ω-phenylpolyoxaalkanes and alkanols in micelles

  摘要：

  DOI：

  10.1016/s0040-4020(01)85934-2

文献信息

• Synthesis and characterization of symmetrical sulfur-fused polycyclic aromatic hydrocarbons with controlled shapes
  作者：Jianghui Yin、Yumiao Hu、Dengqing Zhang、Xianying Li、Wusong Jin

  DOI：10.1016/j.tet.2017.08.020

  日期：2017.9

  Here we report and establish a facile synthetic method for these unprecedented sulfur-fused polycyclic aromatic hydrocarbons (S-PAHs) with symmetrical structures (C2-rectangle and D6h-hexagonal shape). Characterization by laser desorption/ionization time-of-flight mass spectrometry unambiguously validate the successful formation of these novel S-PAHs. The C2-rectangle and D6h-hexagonal-shaped S-PAHs

  这里，我们报告和建立这些前所未有含硫稠合多环芳族烃（S-多环芳烃）具有对称结构（一种简便合成法Ç 2 -rectangle和d 6H -hexagonal形状）。通过激光解吸/电离飞行时间质谱的表征明确验证了这些新型S-PAH的成功形成。的c ^ 2 -rectangle和d 6H -hexagonal形S-多环芳烃（1和2）通过使用的FeCl相应前体的舍尔型环化脱氢得到3作为氧化剂，以及它们的光谱特性，热和电性能进行了研究。
• Development of an aquacatalytic system based on the formation of vesicles of an amphiphilic palladium NNC-pincer complex
  作者：Fumie Sakurai、Go Hamasaka、Yasuhiro Uozumi

  DOI：10.1039/c5dt00434a

  日期：——

  Two amphiphilic palladium NNC-pincer complexes bearing hydrophilic tri(ethylene glycol) chains and hydrophobic dodecyl chains were designed and prepared for the development of a new aquacatalytic system.

  两种含有亲水性三(乙二醇)链和疏水性十二烷基链的两性钯NNC夹心配合物被设计并制备，用于开发新的水相催化系统。
• Mercury detection in a microfluidic device by using a molecular sensor soluble in organoaqueous solvent
  作者：Djibril Faye、Haitao Zhang、Jean-Pierre Lefevre、Jérémy Bell、Jacques A. Delaire、Isabelle Leray

  DOI：10.1039/c2pp25103e

  日期：2012.11

  A series of fluorescent sensor molecules based on a phosphane sulfide derivative that is soluble in an organoaqueous solvent were designed and synthesized. The structure of the fluorophore has been optimized in order to have the best compromise in terms of solubility and photophysical properties. The obtained properties are in full agreement with quantum chemical calculations. A fluorescent molecular sensor containing one polyoxoethylene group has been synthesized and an efficient quenching upon mercury complexation has been observed. Finally, this sensing molecule has been introduced in a microfluidic chip in which fluorescence detection has been integrated. An efficient fluorescence response was observed upon mercury addition.

  设计并合成了一系列基于可溶于有机水相溶剂的磷硫化物衍生物的荧光传感器分子。荧光团的结构经过优化，以在溶解性和光物理性质之间达到最佳折衷。所获得的性质与量子化学计算完全一致。合成了一种含有一个聚氧乙烯基团的荧光分子传感器，观察到在汞复合物形成时发生了有效的猝灭。最后，该传感分子被引入到一个微流控芯片中，并集成了荧光检测。在添加汞后观察到了有效的荧光响应。
• Twisted Charge-Transfer Antennae for Ultra-Bright Terbium(III) and Dysprosium(III) Bioprobes
  作者：Anh Thy Bui、Amandine Roux、Alexei Grichine、Alain Duperray、Chantal Andraud、Olivier Maury

  DOI：10.1002/chem.201705933

  日期：2018.3.7

  design of original twisted charge transfer antennae in which a non‐planar geometry is enforced thanks to one or two bulky ortho‐Me substituents allows us to prepare the corresponding ultra‐bright TbIII and DyIII bioprobes. The brightness of the TbIII derivative compares well with that of the benchmark Tb‐Lumi4 complex. The first bio‐imaging experiments with a DyIII luminescent bioprobe are also reported

  原始的扭曲电荷转移天线的设计由于一个或两个庞大的邻-我取代基而具有非平面几何形状，这使我们能够制备相应的超亮Tb III和Dy III生物探针。Tb III衍生物的亮度与基准Tb-Lumi4复合物的亮度相当。还报道了使用Dy III发光生物探针进行的第一批生物成像实验。
• High-Performance Aqueous/Organic Dye-Sensitized Solar Cells Based on Sensitizers Containing Triethylene Oxide Methyl Ether
  作者：Ryan Yeh-Yung Lin、Feng-Ling Wu、Chun-Ting Li、Pei-Yu Chen、Kuo-Chuan Ho、Jiann T. Lin

  DOI：10.1002/cssc.201500589

  日期：2015.8.10

  Metal‐free dyes (EO1 to EO4) containing the hydrophilic triethylene oxide methyl ether (TEOME) unit in the spacer have been synthesized and used in dye‐sensitized solar cells (DSSCs). Efficient lithium‐ion trapping by TEOME results in improved open‐circuit voltage (VOC), leading to excellent conversion efficiency of the cells, ranging from 9.02 to 9.98 % with I−/I3− electrolyte in acetonitrile under

  合成了在间隔物中包含亲水性三环氧乙烷甲基醚（TEOME）单元的无金属染料（EO1至EO4），并将其用于染料敏化太阳能电池（DSSC）。通过TEOME导致改进的开路电压（有效的锂离子俘获V OC），从而导致细胞的优良转换效率，从9.02到9.98％的I - / I 3 -电解质的乙腈下AM 1.5的照明。TEOME单元还增强了染料分子在水性DSSC中的润湿性。具有双TEMPO /碘化物电解质的水基DSSC表现出较高的V OC值（0.80–0.88 V），电池性能非常有希望，最高可达5.97％。