2,3-O-isopropylidene-1,4-dithiol-Lg-threitol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3-O-isopropylidene-1,4-dithiol-Lg-threitol
• 英文别名: 2,3-O-isopropylidene-1,4-dithiol-L-threitol；(4R)-4r,5t-bis-mercaptomethyl-2,2-dimethyl-[1,3]dioxolane；((4R)-2,2-dimethyl-[1,3]dioxolane-4r,5t-diyl)-bis-methanethiol；[(4R,5R)-2,2-dimethyl-5-(sulfanylmethyl)-1,3-dioxolan-4-yl]methanethiol
• 化学式: C₇H₁₄O₂S₂
• 分子量: 194.319
• InChiKey: BGBHERJPEXJSJO-WDSKDSINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,3-O-isopropylidene-1,4-dithiol-Lg-threitol 在 盐酸 作用下， 以 甲醇 为溶剂， 生成 L-1,4-二硫代苏糖醇
  参考文献：
  名称：

  Synthesis of optically active Cleland's reagent [( - )-1,4-dithio-L-threitol]

  摘要：

  DOI：

  10.1021/jo01269a123

文献信息

• Mononuclear Pt(II) and Pd(II) 1,4-dithiolato complexes. Crystal structures of [Pt((−) DIOS) (PPh3)2] and [Pd(S(CH2) 4S)(Ph2P(CH2) 3PPh2)]. Application in styrene hydroformylation
  作者：J. Forniés-Cámer、A. Aaliti、N. Ruiz、A.M. Masdeu-Bultó、C. Claver、C.J. Cardin

  DOI：10.1016/s0022-328x(96)06662-4

  日期：1997.3

  Ph2P(CH2)4PPh2; dithiolato = −S(CH2)4S−, (−)-DIOS) were prepared by the same method. The structure of [Pt((−)DIOS)(PPh3)2] and [Pd(S(CH2)4S)(Ph2P(CH2)3PPh2)] complexes was determined by X-ray diffraction methods. Pt—dithiolato—SnC12 systems are active in the hydroformylation of styrene. At 100 atm and 125°C [Pt(dithiolate)(P-P)]/SnCl2 (Pt:Sn = 20) systems provided aldehyde conversion up to 80%.

  在[PtCl 2（PP）]（PP =（PPh 3）2，Ph 2 P（CH 2）3 PPh 2，Phd 2 P（CH 2）4 PPh 2 ; 1的二氯甲烷溶液中添加1,4-二硫醇，4-二硫醇= HS（CH 2）4 SH，（-）DIOSH 2（2,3 - O-异亚丙基-1,4-二硫醇-1-苏糖醇），BINASH 2（1,1'-二萘-2， 2'-二硫醇））在NEt 3的存在下产生单核络合物[Pt（1,4-二硫代巯基）（PP）]。相关钯（II）配合物[Pd（dithiolato）（PP）]（PP = Ph2 P（CH 2）3 PPh 2，Ph 2 P（CH 2）4 PPh 2；dithiolato = - S（CH 2）4小号- ，（- ） - DIOS）通过相同的方法制备。通过X射线衍射确定[Pt（（-）DIOS）（PPh 3）2 ]和[Pd（S（CH 2）4 S）（Ph 2 P（CH 2）3 PPh
• Synthesis and Properties of Novel Medium-sized Heterocyclic Compounds Containing Two Sulfur Atoms in the Ring and Synthetic Approaches to Conjugated Cyclic Disulfonium Ylides
  作者：Hiroshi Shimizu、Hiroyoshi Watanabe、Masahiro Mizuno、Tadashi Kataoka、Mikio Hori

  DOI：10.3987/com-99-s(i)5

  日期：——

  Tribenzo[b,f,h][1,4]dithiecin (8) was prepared by coupling 2,2'-bis(bromomethyl)biphenyl (10) with 1,2-benzenedithiol (11) in the presence of NaH in acetonitrile. Another novel dithiecin derivative, 1,8-dihydro-2,7-benzodithiecin (9) was synthesized by coupling of 1,4-dimercapto-2,3-O-isopropylidene-Lg-threitol (13a) with alpha,alpha'-dibromo-o-xylene (12), followed by hydrolysis and subsequent dehydration via the mesylate derivative (16). The benzodithiecin (9) was also prepared by treatment of dithiol (18) with butadiyne along with alpha,alpha'-bis(1-buten-3-ynylthio)-o-xylene (19) as a byproduct. Compound (19) was subjected to an intramolecular coupling reaction using CuCl-pyridine-O-2 in benzene to yield the 12-membered ring compound (23). We also describe our effort to prepare the corresponding cyclic diylide compounds from the above new dithiecins (8) and (9), and known dithiecin (7).
• COMPOSITION FOR THE TREATMENT OF A BONE FRACTURE
  申请人：Biomedical Bonding AB

  公开号：EP2490727B1

  公开（公告）日：2020-09-23