4-[(四氢化-2-呋喃基)氧基]-1-丁醇 | 64001-06-5

• 物质功能分类: 香精与香料 - 合成香料 - 内酯和含氧杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 中文名称: 4-[(四氢化-2-呋喃基)氧基]-1-丁醇
• 中文别名: 2-(4-羟基丁氧基)四氢呋喃
• 英文名称: 2-(4'-hydroxybutoxy)-tetrahydrofuran
• 英文别名: 2-(4-hydroxybutyloxy)tetrahydrofuran；2-(4'-hydroxybutoxy)tetrahydrofuran；2-(4-hydroxybutoxy)-tetrahydrofuran；2-(4-hydroxybutoxy)tetrahydrofurane；2-(4-hydroxybutoxy)tetrahydrofuran；4-((Tetrahydrofuran-2-yl)oxy)butan-1-ol；4-(oxolan-2-yloxy)butan-1-ol
• CAS: 64001-06-5
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: NMPJHMFXHISVBR-UHFFFAOYSA-N

物化性质

• 沸点：
  260.0±35.0 °C(Predicted)
• 密度：
  1.04±0.1 g/cm3(Predicted)
• 溶解度：
  氯仿（微溶）、乙酸乙酯（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2932190090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335
• 储存条件：
  存储条件：2-8°C，需干燥密封保存。

制备方法与用途

应用4-[(四氢化-2-呋喃基)氧基]-1-丁醇作为有机合成中间体和医药中间体，主要应用于实验室研发及化工生产过程。

反应信息

• 作为反应物：
  描述：

  4-[(四氢化-2-呋喃基)氧基]-1-丁醇 以17%的产率得到1,4-二(2-四氢呋喃基氧基)丁烷
  参考文献：
  名称：

  Preparation of 1,4-butanediol and tetrahydrofuran

  摘要：

  含有1,4-丁二醇和四氢呋喃的混合物是通过在存在或不存在1,4-丁二醇的情况下，在20℃-300℃下加热式的4-羟基丁醛的制备，并将所得的式为##STR2##的缩醛在50℃-300℃和1-350巴的催化氢化下处理而得到的。

  公开号：

  US05008408A1
• 作为产物：
  描述：

  2-(4-Phenylmethoxybutoxy)oxolane 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 为溶剂， 以58 %的产率得到4-[(四氢化-2-呋喃基)氧基]-1-丁醇
  参考文献：
  名称：

  [EN] GAMMA-HYDROXYBUTYRATE DELIVERING COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM
  [FR] COMPOSÉS D'ADMINISTRATION DE GAMMA-HYDROXYBUTYRATE ET LEURS PROCÉDÉS DE PRÉPARATION ET MÉTHODES D'UTILISATION

  摘要：

  Disclosed are compounds comprising chemically modified gamma-hydroxybutyrate (GHB) having the structure of Formula I, and salts of such compounds (GHB delivering compounds and salts thereof). Also disclosed are compositions comprising at least one GHB delivering compound, or a salt thereof, methods of making such compounds, and methods of using such GHB delivering compounds and compositions. Methods of treatment are also disclosed.

  公开号：

  WO2023205233A1

文献信息

• PROCESS FOR PRODUCING POLYHYDRIC ALCOHOL
  申请人：KURARAY CO., LTD.

  公开号：US20160115108A1

  公开（公告）日：2016-04-28

  A process for producing a polyhydric alcohol includes a step (I) of hydrogenating hemiacetal having a specific structure to obtain a reaction solution (I), and a step (II) of adding water to the reaction solution (I) obtained in the step (I) and further conducting hydrogenation.

  生产多元醇的过程包括以下步骤：步骤（I）对具有特定结构的半缩醛进行加氢反应，得到反应溶液（I）；步骤（II）向步骤（I）中得到的反应溶液（I）中加入水，然后继续进行加氢反应。
• [EN] PROCESS FOR PRODUCING 1,4- BUTANEDIOL BY HYDROGENATING DIALKYL MALEATE IN MIXED LIQUID/VAPOR PHASE<br/>[FR] PROCÉDÉ DE PRODUCTION DE 1,4-BUTANEDIOL PAR HYDROGÉNATION DE MALÉATE DE DIALKYLE DANS UNE PHASE MIXTE LIQUIDE/VAPEUR
  申请人：CONSER SPA

  公开号：WO2013076747A1

  公开（公告）日：2013-05-30

  A process is described for the production of 1,4-butanediol and tetrahydrofuran by catalytic hydrogenation of dialkyl maleates. The process consists essentially in the following steps: a) hydrogenating a stream of dialkyl maleate in a first stage of reaction over suitable catalysts to produce dialkyl succinate; b) further hydrogenating the dialkyl succinate in a second stage of reaction, by using a different suitable catalyst, for producing mainly 1,4-butanediol, together with gamma-butyrolactone and tetrahydrofuran as co-products. In both stages of reaction the conditions, as hydrogen/ organic feed ratio, pressure and temperature, are such to maintain the reactors in mixed liquid/vapor phase.

  描述了一种通过催化加氢二烯丙二酸二烷基酯生产1,4-丁二醇和四氢呋喃的方法。该过程主要包括以下步骤：a) 在适当的催化剂作用下，在第一阶段的反应中加氢处理二烯丙酸二烷基酯流以产生二烷基琥酯；b) 进一步在第二阶段的反应中使用不同的适当催化剂加氢处理二烷基琥酯，主要产生1,4-丁二醇，同时生成γ-丁内酯和四氢呋喃作为共同产物。在两个反应阶段中，通过氢气/有机物料比、压力和温度等条件，使反应器保持在混合液/气相状态。
• METHODS FOR PRODUCING TETRAHYDROFURAN
  申请人：DAIREN CHEMICAL CORPORATION

  公开号：US20210061780A1

  公开（公告）日：2021-03-04

  The present disclosure provides a method for producing tetrahydrofuran (THF). The method includes: feeding 1,4-butanediol into a reactive distillation apparatus; performing the dehydration reaction in the presence of an acidic catalyst; and producing the top stream containing product THF and the bottom stream from the reactive distillation apparatus, wherein a weight ratio of a water content in the bottom stream to a water content in the top stream is 0.05 to 2.4, thereby providing a high conversion rate and more cost-effectiveness, and enhancing the value of the industrial application.

  本公开提供一种生产四氢呋喃（THF）的方法。该方法包括：将1,4-丁二醇送入反应精馏装置；在酸性催化剂存在下进行脱水反应；并从反应精馏装置产生含有产品THF的顶部流和底部流，其中底部流中水含量与顶部流中水含量的重量比为0.05至2.4，从而提供高转化率和更具成本效益性，并增强工业应用的价值。
• Method for producing 1,4-butanediol
  申请人：BASF Aktiengesellschaft

  公开号：US06350924B1

  公开（公告）日：2002-02-26

  A process for preparing 1,4-butanediol and, if desired, &ggr;-butyrolactone and THF by oxidizing butane or benzene to form a product stream including maleic anhydride, absorbing maleic anhydride from the product stream with a high-boiling inert solvent in an absorption stage to give a liquid absorption product, esterifying the liquid absorption product with a C1-C5 esterifying alcohol in an esterification stage to form an esterification product comprising the corresponding diester and high-boiling inert solvent, then hydrogenating the esterification product to give a hydrogenation product which comprises the products of value, 1,4-butanediol and, if desired, &ggr;-butyrolactone and tetrahydrofuran and the esterifying alcohol and which is separated by distillation into the products of value and the esterifying alcohol, and recycling the esterifying alcohol to the esterification zone, which comprises separating the esterification product into the diester and the inert solvent by distillation under reduced pressure prior to the hydrogenation, recycling the inert solvent to the absorption stage, and hydrogenating the diester in the liquid phase over a fixed-bed catalyst.

  一种制备1,4-丁二醇，如有需要还包括γ-丁内酯和THF的方法，通过氧化丁烷或苯生成包括马来酸酐的产品流，用高沸点惰性溶剂在吸收阶段从产品流中吸收马来酸酐，得到液体吸收产物，将液体吸收产物与C1-C5酯化醇在酯化阶段酯化，形成包括相应二酯和高沸点惰性溶剂的酯化产物，然后加氢酯化产物，得到包括有价值产品1,4-丁二醇，如有需要还包括γ-丁内酯和四氢呋喃和酯化醇的加氢产物，通过蒸馏分离为有价值产品和酯化醇，将酯化醇回收到酯化区域，其中包括在加氢之前通过减压蒸馏将酯化产物分离为二酯和惰性溶剂，将惰性溶剂回收到吸收阶段，液相中在固定床催化剂上加氢二酯。
• METHOD FOR PRODUCING TETRAHYDROFURAN
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US20140121390A1

  公开（公告）日：2014-05-01

  The present invention relates to a method for producing tetrahydrofuran comprising: feeding raw material 1,4-butanediol containing gamma butyrolactone to a reaction tank, and performing a dehydration cyclization reaction in the presence of a homogeneous acid catalyst having a pKa of 4 or less and being dissolvable in 1,4-butanediol to produce tetrahydrofuran, wherein a gas containing tetrahydrofuran, gamma butyrolactone and water in the reaction tank is introduced into a heat exchanger and when obtaining a condensate from the outlet of the heat exchanger, the ratio of the concentration of gamma butyrolactone in the condensate based on the concentration of gamma butyrolactone in the raw material 1,4-butanediol is from 20 to 100%.

  本发明涉及一种生产四氢呋喃的方法，包括：将含有γ-丁内酯的原料1,4-丁二醇送入反应罐，在存在具有pKa值为4或更低且可溶于1,4-丁二醇的均相酸催化剂的情况下进行脱水环化反应，以产生四氢呋喃，其中在反应罐中含有四氢呋喃、γ-丁内酯和水的气体被引入换热器，当从换热器出口获取冷凝物时，基于原料1,4-丁二醇中γ-丁内酯浓度的浓度比为20%至100%。