4-Hydroxy-2-quinolones 155*. Bioreversible chemical modification of chinoxycaine at the tertiary amino group as a method of improving its pharmaceutical activity
摘要:
There are discussed several variants of the chemical modification of the local anesthetic chinoxicaine at the tertiary amino group, initially in use as the hydrochloride. It was found that a significant improvement in its pharmaceutical properties can be achieved by exchange of the hydrogen chloride for an alternative salt forming acid component.
4-Hydroxy-2-quinolones 155*. Bioreversible chemical modification of chinoxycaine at the tertiary amino group as a method of improving its pharmaceutical activity
摘要:
There are discussed several variants of the chemical modification of the local anesthetic chinoxicaine at the tertiary amino group, initially in use as the hydrochloride. It was found that a significant improvement in its pharmaceutical properties can be achieved by exchange of the hydrogen chloride for an alternative salt forming acid component.