16,17-二氢-17-甲基-15H-环戊二烯并[a]菲 | 549-38-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 中文名称: 16,17-二氢-17-甲基-15H-环戊二烯并[a]菲
• 英文名称: 17-methyl-16,17-dihydro-15H-cyclopenta[a]phenanthrene
• 英文别名: 17-Methyl-16,17-dihydro-15H-cyclopenta-phenanthren；3'-Methyl-1,2-cyclopentenophenanthrene；17-methyl-16,17-dihydro-15H-cyclopenta[a]phenanthrene
• CAS: 549-38-2
• 化学式: C₁₈H₁₆
• 分子量: 232.325
• InChiKey: GRGSXXHCCGOGRX-UHFFFAOYSA-N

物化性质

• 保留指数：
  374.63;375.72

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

SDS

反应信息

• 作为反应物：
  描述：

  16,17-二氢-17-甲基-15H-环戊二烯并[a]菲 、 硝酸 生成 苯偏四甲酸
  参考文献：
  名称：

  Hillemann, Chemische Berichte, 1935, vol. 68, p. 102,104

  摘要：

  DOI：
• 作为产物：
  描述：

  cholesterol 在 selenium 作用下， 生成 16,17-二氢-17-甲基-15H-环戊二烯并[a]菲
  参考文献：
  名称：

  The Effect of Laboratory-Induced Depressed Mood State on Responses to Pain

  摘要：

  Some researchers have suggested that a depressed mood state is associated with alterations in responses to pain. The authors examined cognitive, behavioral, and affective responses of 75 randomly assigned participants to depressed, neutral, or elated mood state induction conditions and subjected them to the cold-pressor task. Because they were unsuccessful in inducing elated moods, the authors used only the data for the depressed and neutral states as they measured pain threshold, tolerance, and unpleasantness during the test. After the task, the authors measured sensory, affective, and evaluative responses to the cold-pressor pain, as well as the participants' catastrophizing ideation about the painful procedure. The depressed mood state group, compared with the neutral group, had significantly lower cold-pressor tolerance times and higher pain catastrophizing scores. These results support previous findings that a depressed mood state may be associated with alterations in some pain responses.

  DOI：

  10.1080/08964280209596395

文献信息

• Combustion synthesis of mechanically activated powders in the Nb–Si system
  作者：Filippo Maglia、Chiara Milanese、Umberto Anselmi-Tamburini、Stefania Doppiu、Giorgio Cocco

  DOI：10.1557/jmr.2002.0295

  日期：2002.8

  The effect of the mechanical activation of the reactants on the self-propagating high-temperature synthesis (SHS) of niobium silicides was investigated. SHS experiments were performed on reactant powder blends of composition Nb:Si = 1:2 and Nb:Si = 5:3 pretreated for selected milling times. A self-sustaining reaction could be initiated when a sufficiently long milling time was employed. At short milling

  研究了反应物的机械活化对铌硅化物自蔓延高温合成 (SHS) 的影响。SHS 实验是对组成 Nb:Si = 1:2 和 Nb:Si = 5:3 的反应物粉末混合物进行的，这些混合物经过选定的研磨时间预处理。当使用足够长的研磨时间时，可以引发自持反应。在较短的研磨时间内，反应自熄或以不稳定模式传播。燃烧峰值温度、波速和产品成分受研磨处理长度的显着影响。足够长的研磨时间可以获得单相产品。
• Potentially carcinogenic cyclopenta[a]phenanthrenes (1,2-cyclopentenophenanthrenes). Part II. Derivatives containing further unsaturation in ring D
  作者：M. M. Coombs

  DOI：10.1039/j39660000963

  日期：——

  the Δ15– 17H-compound (A), but at 100° the Δ16– 15H-isomer was formed. Base-catalysed condensation of (A) with acetone and aryl aldehydes yielded 17-substituted-methylene derivatives. The chemical shifts of protones attached to ring D in these compounds are listed.

  通过格氏反应从相应的15,16-二氢-17-酮制备了取代的17-甲基-15 H-环戊[ a ]菲，并将其还原为Diels烃的类似物。通过Witting反应获得15，16-二氢-17-亚甲基衍生物（未取代）。消除从17甲苯p在170 -sulphonyloxy化合物°得到Δ 15 - 17 ħ -化合物（A），但在100℃的Δ 16 - 15 ħ形成异构体。（A）与丙酮和芳基醛的碱催化缩合产生17-取代的亚甲基衍生物。列出了这些化合物中连接在环D上的质子的化学位移。
• Synthesis of polycyclic compounds. Part VIII. Friedel–Crafts acylation with anhydrides of tricarboxylic acids. Synthesis of 16,17-dihydro-17-methyl-15H-cyclopenta[a]phenanthrene
  作者：K. R. Tatta、J. C. Bardhan

  DOI：10.1039/j39680000893

  日期：——

  The acylation of naphthalene, 1- and 2-methylnaphthalenes, and 1,2,3,4-tetrahydronaphthalenes with propane-1,2,3-tricarboxylic acid 1,2-anhydride and its 2-methyl derivative is described. 1,2,3,4-Tetrahydro-oxophenanthreneacetic acids have been prepared in good yields by this method. The structures of the intermediates were established by independent syntheses. The keto-acid formed by acylation of naphthalene

  描述了萘，1-和2-甲基萘以及1,2,3,4-四氢萘与丙烷-1,2,3-三羧酸1,2-酐及其2-甲基衍生物的酰化作用。通过这种方法已经以高收率制备了1,2,3,4-四氢-氧杂菲乙酸。中间体的结构是通过独立合成建立的。通过萘与3-甲基丁烷-1,2,4-三羧酸1,2-酐的酰化反应生成的酮酸已被用于一种新的，改进的生产16,17-二氢-17-甲基-15 H-的途径。环戊[ a ]菲（Diels烃）。由萘和2-甲基丙烷-1,2,3-三羧酸的酮酸-1,2-酐转化成外消旋的雌-1,3,5（10），6,8-五烯-17-酮[反式-（±）-3-deoxyequilenin]通过已知方法。
• Butenandt; Suranyi, Chemische Berichte, 1942, vol. 75, p. 597,603
  作者：Butenandt、Suranyi

  DOI：——

  日期：——
• The Strophanthidin Dehydrogenation Product C₂₁H₁₆
  作者：Ernst Bergmann

  DOI：10.1021/ja01277a009

  日期：1938.10