(2S,2'S)-2,2'-(((hydrazine-1,2-diylidenebis(methaneylylidene))bis(6-methoxy-3,1-phenylenesulfonyl))bis(azanediyl))bis(3-methylbutanoic acid) | 1015074-25-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,2'S)-2,2'-(((hydrazine-1,2-diylidenebis(methaneylylidene))bis(6-methoxy-3,1-phenylenesulfonyl))bis(azanediyl))bis(3-methylbutanoic acid)
• CAS: 1015074-25-5
• 化学式: C₂₆H₃₄N₄O₁₀S₂
• 分子量: 626.709
• InChiKey: MMCCWJJYVBTLIP-ZEQRLZLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.93
• 重原子数：
  42.0
• 可旋转键数：
  15.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  210.12
• 氢给体数：
  4.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  (2S,2'S)-2,2'-(((hydrazine-1,2-diylidenebis(methaneylylidene))bis(6-methoxy-3,1-phenylenesulfonyl))bis(azanediyl))bis(3-methylbutanoic acid) 在 氯化亚砜 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 27.0h， 生成
  参考文献：
  名称：

  A Comparative Study on Some Diaryl Azines Amino Acid Derivatives

  摘要：

  Benzaldehydeazines, p-anisaldehydeazines, and thiophene-2-carboxaldehyde azines react with excess chlorosulfonic acid to give corresponding disulfonyl chlorides 1,13, and 24. These were condensed with nucleophiles to give disulfonyl amino acid derivatives, 2-4, 14-16, and 25-27. Some of the corresponding methyl esters were prepared: 5-6, 17-18, and 28-29. Hydrazinolysis of these methyl esters yielded hydrazides 7-8, 19-20, and 30-31. Coupling reactions of some amino acid derivatives, in THF-Et8N medium using the dicyclohexylcarbodiimide method DCC, furnished dipeptide methyl esters 9-12, 21-23, and 32-34. Attemped chlorosulfonation of furan-2-carboxaldehyde azine were unsuccessful. Some spectra data are briefly discussed.

  DOI：

  10.1080/10426500601142155
• 作为产物：
  描述：

  4-甲氧基二氮苯甲醛 在 氯磺酸 、 三乙胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 4.5h， 生成 (2S,2'S)-2,2'-(((hydrazine-1,2-diylidenebis(methaneylylidene))bis(6-methoxy-3,1-phenylenesulfonyl))bis(azanediyl))bis(3-methylbutanoic acid)
  参考文献：
  名称：

  A Comparative Study on Some Diaryl Azines Amino Acid Derivatives

  摘要：

  Benzaldehydeazines, p-anisaldehydeazines, and thiophene-2-carboxaldehyde azines react with excess chlorosulfonic acid to give corresponding disulfonyl chlorides 1,13, and 24. These were condensed with nucleophiles to give disulfonyl amino acid derivatives, 2-4, 14-16, and 25-27. Some of the corresponding methyl esters were prepared: 5-6, 17-18, and 28-29. Hydrazinolysis of these methyl esters yielded hydrazides 7-8, 19-20, and 30-31. Coupling reactions of some amino acid derivatives, in THF-Et8N medium using the dicyclohexylcarbodiimide method DCC, furnished dipeptide methyl esters 9-12, 21-23, and 32-34. Attemped chlorosulfonation of furan-2-carboxaldehyde azine were unsuccessful. Some spectra data are briefly discussed.

  DOI：

  10.1080/10426500601142155