potassium succinate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: potassium succinate
• 英文别名: dipotassium succinate；Potassium;butanedioate
• 化学式: C₄H₄O₄*2K
• 分子量: 194.27
• InChiKey: PWARIDJUMWYDTK-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -5.73
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  potassium succinate 在 硝酸 作用下， 以 水 为溶剂， 生成 丁二酸
  参考文献：
  名称：

  Influence of the temperature on heat effects of acid-base interactions in aqueous solutions of succinic and tartaric acids

  摘要：

  The heat effects of interactions of solutions of succinic and tartaric acids with solutions of HNO3 and KOH or LiOH are measured over the temperature range 288.15-308.15 K at ionic strengths of 0.5, 1.0, and 1.5 (KNO3 or LiNO3). The heat effects of dissociation of the acids are calculated using a Pentium-150 PC with HEAT and RRSU universal software packages. The thermodynamic characteristics of the processes of stepwise dissociation of the oxyacids are determined. The influence of the temperature on the heat effects of the processes of stepwise dissociation of succinic and tartaric acids is discussed.

  DOI：

  10.1134/s0036024407060131
• 作为产物：
  描述：

  N-硝基琥珀酰亚胺 在 氢氧化钾 、 乙醇 作用下， 反应 2.0h， 以98%的产率得到potassium succinate
  参考文献：
  名称：

  The chemistry of nitroimides. 3. Alkaline hydrolysis and alcoholysis of nitroimides and their reactions with ammonia, amines, and potassium iodide

  摘要：

  DOI：

  10.1007/bf01094642
• 作为试剂：
  描述：

  丁二酰氯 、 anilino-guanidine 在 盐酸 、 potassium succinate 作用下， 生成 1,1'-diphenyl-1H,1'H-5,5'-ethanediyl-bis-[1,2,4]triazol-3-ylamine
  参考文献：
  名称：

  Cuneo, Gazzetta Chimica Italiana, 1899, vol. 29, p. I 105

  摘要：

  DOI：

文献信息

• Replacement of Chlorides with Dicarboxylate Ligands in Anticancer Active Ru(II)-DMSO Compounds:  A New Strategy That Might Lead to Improved Activity
  作者：Ioannis Bratsos、Barbara Serli、Ennio Zangrando、Nikos Katsaros、Enzo Alessio

  DOI：10.1021/ic0613964

  日期：2007.2.1

  dicarb)] (dicarb = mal, 6; mmal, 9; ox, 14) that contains a chelating dicarboxylate unit and a residual chloride. Likewise, when 3 was used as a precursor, the neutral mononuclear species fac-[Ru(DMSO-O)(DMSO-S)3(eta2-dicarb)] (dicarb = mal, 7; mmal, 10; ox, 16), which contains a DMSO-O ligand in the place of Cl-, was obtained. On the contrary, K2(suc) and K2(dmmal) yielded preferentially the dinuclear

  合成了一系列新的含二羧酸酯配体（dicarb）的Ru（II）-DMSO配合物，即草酸酯（ox），丙二酸酯（mal），丙二酸甲酯（mmal），丙二酸二甲酯（dmmal）和琥珀酸酯（suc）。结构特征。这些化合物是从已知的Ru（II）-Cl-DMSO抗癌复合物cis，fac- [RuCl2（DMSO-S）3（DMSO-O）]（1）和反式-[RuCl2（DMSO-S）4]制备的（2）和不含氯的前体fac- [Ru（DMSO-S）3（DMSO-O）3] [CF3SO3] 2（3），目的是评估阴离子配体的性质如何影响生物这些物种的活动。基本上，所研究的配体可以分为两组。1或2与K2（dicarb）（dicarb = ox，mal，mmal）的反应优先产生单核种[K] fac- [RuCl（DMSO-S）3（eta2-dicarb）]（dicarb = mal， 6； mmal，9；黄牛，14）含有螯
• Dicopper(<scp>ii</scp>) complexes of a new di-para-xylyldioxatetraazamacrocycle and cascade species with dicarboxylate anions: thermodynamics and structural properties
  作者：Sílvia Carvalho、Rita Delgado、Michael G. B. Drew、Vítor Félix

  DOI：10.1039/b700115k

  日期：——

  The new dioxatetraazamacrocycle (L1) was synthesized by a 2 + 2 condensation and characterized. Stability constants of its copper(II) complexes were determined by spectrophotometry in DMSO at 298.2 K in 0.10 mol dm−3 KClO4. Mainly dinuclear complexes are formed and the presence of mononuclear species is dependent on the counterion (Cl− or ClO4−). The association constants of the dinuclear copper(II) complexes with dicarboxylate anions [oxalate (oxa2−), malonate (mal2−), succinate (suc2−), and glutarate (glu2−)] were also determined by spectrophotometry at 298.2 K in DMSO, and it was found that values decrease with an increase of the alkyl chain between the carboxylate groups. X-Band EPR spectra of the dicopper(II) complexes and of their cascade species in frozen DMSO exhibit dipole–dipole coupling, and their simulation, together with their UV-vis spectra, showed that the copper centres of the complexes in solution had square pyramidal geometries though with different distortions. From the experimental data, it was also possible to predict the Cu⋯Cu distances, the minimum being found at 6.4 Å for the Cu2L1Cl4 complex and then successively this distance slightly increases when the chloride anions are replaced by dicarboxylate anions, from 6.6 Å for oxa2− to 7.8 Å for glu2−. The crystal structures of the dinuclear copper cascade species with oxa2− and suc2− were determined and showed one anion bridging both copper centres and Cu⋯Cu distances of 5.485(7) Å and 6.442(8) Å, respectively.

  新合成的二氧四氮大环化合物（L1）通过2 + 2冷凝反应合成并进行了表征。其铜(II)复合物的稳定常数在298.2 K、0.10 mol dm−3 KClO4的DMSO中通过光谱法确定。主要形成双核复合物，单核物种的存在取决于对离子（Cl−或ClO4−）。双核铜(II)复合物与二羧酸盐阴离子[草酸（oxa2−）、苹果酸（mal2−）、琥珀酸（suc2−）和戊二酸（glu2−）]的结合常数也在298.2 K的DMSO中通过光谱法确定，结果表明，值随着羧酸盐基团之间烷基链的增加而减小。冻存DMSO中双铜(II)复合物及其级联物种的X波段EPR光谱显示了偶极-偶极耦合，其模拟结果以及UV-vis光谱表明，复合物中的铜中心在溶液中具有方锥几何结构，但畸变不同。根据实验数据，还可以预测Cu⋯Cu距离，最小值为6.4 Å（Cu2L1Cl4复合物），然后随着氯离子被二羧酸盐阴离子取代，该距离略微增加，从oxa2−的6.6 Å到glu2−的7.8 Å。确定了含有oxa2−和suc2−的双核铜级联物种的晶体结构，显示一个阴离子桥接两个铜中心，Cu⋯Cu距离分别为5.485(7) Å和6.442(8) Å。
• Dicarboxylate Recognition by Two Macrobicyclic Receptors: Selectivity for Fumarate over Maleate
  作者：Pedro Mateus、Rita Delgado、Paula Brandão、Vítor Félix

  DOI：10.1021/jo300320w

  日期：2012.5.18

  Two ditopic polyamine macrobicyclic compounds have been studied as receptors for the recognition of dicarboxylate anions of varying chain length in aqueous solution. One of the receptors consists of two tris(2-aminoethyl)amine-derived binding subunits separated by p-xylyl spacers, while the other is a heteroditopic compound, combining two different head units, a tren-derived and a 2,4,6-triethylbenzene-derived

  已经研究了两种二位多胺多胺大环化合物作为受体，用于识别水溶液中链长不同的二羧酸根阴离子。其中一个受体由两个由对三甲苯基间隔基隔开的三（2-氨基乙基）胺衍生的结合亚基组成，另一个受体是一个杂二位化合物，结合了两个不同的头部，一个是tren衍生的，一个是2,4,6 -三乙苯衍生的，也被对-二甲苯基间隔基隔开。化合物的酸碱行为以及它们与草酸盐（oxa 2–），丙二酸盐（mal 2–），琥珀酸盐（suc 2–），谷氨酸盐（glu 2–），马来酸盐（男性2–）和富马酸盐（烟气2 –在水溶液中以298.2 K进行电位分析，在KTsO中以0.10 M的离子强度进行阴离子研究。还进行了NMR研究，以了解溶液中有关通过质子化大环化合物与二羧酸酯底物缔合而形成的超分子的结构信息。结果表明，这两种化合物能够形成具有在竞争性水溶液中的二价阴离子基片稳定协会，以前所未有的选择性FUM 2-比其它二羧酸的竞争者，包括
• Derivatives of L-carnitine
  申请人：Magis Farmaceutici Srl

  公开号：US04883786A1

  公开（公告）日：1989-11-28

  Novel derivatives of L-carnitine or of L-acylcarnitines or of esters thereof, obtained by salification with suitable acids or acidic aminoacids, monosalified with potassium ion. These derivatives show cardiotropic properties in the therapy of myocardial anoxia, of ischemia, of arrythmic syndromes, of cardiac failures in general and in cases of increased energy request due to fatigue at cardiac and muscular level.

  新型的L-肉碱衍生物或L-酰基肉碱或其酯类，通过与适当的酸或酸性氨基酸盐化得到，并且以钾离子单盐化。这些衍生物在治疗心肌缺氧、缺血、心律失常综合症、一般的心力衰竭和由于心肌和肌肉疲劳导致的能量需求增加的情况下，表现出心脏肌肉选择性作用。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Sc: MVol.D5, 1.2.5.3, page 171 - 173
  作者：

  DOI：——

  日期：——