sodium N,N-diethyldithiocarbamate | 148-18-5

• 物质功能分类: 有机原料 - 有机金属盐
• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: sodium N,N-diethyldithiocarbamate
• 英文别名: sodium diethyldithiocarbamate；sodium diethylcarbamodithioate；DDC；sodium N,N-diethylcarbamodithioate；DDTC；sodium diethyldithiocarbamate trihydrate；N,N-diethyldithiocarbamate sodium salt；diethyldithiocarbamate sodium；sodium diethylthiocarbamate；DTC；N,n-diethyldithiocarbamic acid sodium salt；diethyl dithiocarbamic acid sodium salt；Ditiocarb sodium；Na(DDTC)；DEDTC；sodium;N,N-diethylcarbamodithioate
• CAS: 148-18-5
• 化学式: C₅H₁₀NNaS₂
• 分子量: 171.263
• InChiKey: IOEJYZSZYUROLN-UHFFFAOYSA-M

物化性质

• 熔点：
  95°C
• 密度：
  1.1000
• 溶解度：
  about 35 % in water, less soluble in organic solvents. However, the free acid, diethyldithiocarbamic acid, is readily soluble in organic solvents and less soluble in water. Thus, on acidification of an aqueous solution of a diethyldithiocarbamate, the free acid can be extracted with chloroform or carbon tetrachloride. The distribution ratio is 2,360 for chloroform and 343 for carbon tetrachloride.
• LogP：
  -1.1 at 20℃
• 物理描述：
  Sodium diethyldithiocarbamate appears as odorless white or slightly brown or slightly pink crystals. (NTP, 1992)
• 颜色/状态：
  Yellow to green liquid at 20 °C and 1013 hPa (solution in water)
• 蒸汽密度：
  5.9 (NTP, 1992) (Relative to Air)
• 稳定性/保质期：

  遇到酸会分离出二硫化碳，使溶液变得浑浊。遇明火或高温可燃。其粉末与空气混合时可能形成爆炸性混合物，当浓度达到一定水平，遇火星会发生爆炸。受高热分解会产生有毒气体。

• 分解：
  When heated to decomposition it emits very toxic fumes of /nitrogen, sulfur, and sodium oxides/.
• 解离常数：
  pKa = 2.00 (thiol) (est)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.84
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  2

ADMET

代谢

在大鼠中，确定了四种代谢物，分别是二乙基二硫代氨基甲酸酯、二乙基二硫代氨基甲酸酯-S-葡萄糖苷酸、无机硫酸盐和二硫化碳；这些也是戒酒药双硫仑的代谢物。

In rats, four metabolites, diethyldithiocarbamate, diethyldithiocarbamate-s-glucuronide, inorganic sulfate and carbon disulfide were identified; these are also metabolites of disulfiram.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 毒性总结

识别和使用：二乙基二硫代氨基甲酸钠（DETC）是一种固体。它被用作腐蚀抑制剂、橡胶加速剂、中间体、聚合终止剂，以及生产双（硫代氨基甲酰）硫醚（橡胶加工加速剂和杀菌剂）的化学中间体。它还用于测定少量铜的比色法，以及从其他金属中分离铜，还作为捕捉剂（作为FeDETC络合物）用于检测一氧化氮。DETC也被用作治疗药物和对镍羰基暴露的解毒剂。人类暴露和毒性：与湿式潜水服相关的接触性皮炎是由二乙基二硫代氨基甲酸锌引起的。动物研究：二乙基二硫代氨基甲酸锌和DETC在小鼠局部淋巴结试验（LLNA）中呈阳性。系统性给药时，据报道DETC在狗身上引起了视网膜脱落，但在猴子身上没有对视网膜造成损害。在白化大鼠和比格犬中，每天给药九十天没有影响视力或眼睛的结构改变。在小鼠的6周实验中，每天皮下注射50毫克/千克体重显著具有抗甲状腺活性。将DETC以100、200和400毫克/千克每天的剂量给予兔子，持续4周，增加了三酸甘油酯和磷脂水平。血清胆固醇浓度没有变化。DETC降低了血液中的铜含量。在整个怀孕期间每周5天静脉注射0.5克二乙基二硫代氨基甲酸钠的怀孕兔子未能分娩。DETC提高了大脑和周围神经中的铜水平，导致氧化应激和脂质过氧化。脂质过氧化似乎要么是脱髓鞘发展的促进事件，可能是由于活性铜的增加，要么是髓鞘损伤的结果。持续的DETC暴露导致轴突和髓鞘的广泛退化（轴突的沃勒变性）。在NTP生物检测中，DETC对大鼠或小鼠没有致癌性。在使用Salmonella typhimurium菌株（TA1535、TA1537、TA97、TA98和TA100）进行测试时，无论是否存在代谢激活，二乙基二硫代氨基甲酸钠都是阴性的。然而，在蚕豆中发现了染色体断裂和畸变的小幅但显著增加。口服给予幼年和成年家禽DETC，产生了睾丸发育迟缓，并在成熟鸟类的生精上皮中产生了变性。在雏鸡的延髓和脊髓中产生了神经纤维变性。生态毒性研究：DETC>3毫克/升应用于发育中的青蛙胚胎，在24小时内是致命的。在1-3毫克/升之间导致胚胎严重畸形。观察到生长迟缓、体轴弯曲、一般水肿状况、色素沉着障碍和异常脊索。

IDENTIFICATION AND USE: Sodium diethyldithiocarbamate (DETC) is a solid. It is used as corrosive inhibitor, rubber accelerator, intermediate, polymerization shortstop, and chemical intermediate in production of bis(thiocarbamoyl)sulfides (rubber-processing accelerators and fungicides). It is also used for colorimetric determination of small quantities of copper and for its separation from other metals, as well as spin trap (as FeDETC complex) for nitric oxide detection. DETC has also been used as a medication and antidote in nickel carbonyl exposures. HUMAN EXPOSURE AND TOXICITY: Allergic contact dermatitis from a wet suit was related to zinc diethyldithiocarbamate. ANIMAL STUDIES: Zinc diethyldithiocarbamate and DETC were positive in the murine local lymph node assay (LLNA). Administered systemically, DETC is reported to have caused detachment of the retina in dogs, but no damage to the retina in monkeys. In albino rats and beagle dogs, it caused no impairment of vision or structural alteration in the eye after daily administration for ninety days. In a 6-wk experiment in mice, daily sc injection of 50 mg/kg bw had marked anti-thyroid activity. DETC administered to rabbits at 100, 200, and 400 mg/kg daily for 4 weeks increased triglyceride and phospholipid levels. No changes were found in serum cholesterol concentration. DETC reduces blood copper concentrations. Pregnant rabbits injected intravenously with 0.5 g sodium diethyldithiocarbamate/day on 5 days per week throughout pregnancy failed to deliver litters. DETC elevated copper levels in the brain and peripheral nerve, leading to oxidative stress and lipid peroxidation from redox cycling of copper. Lipid peroxidation appears to either be a contributing event in the development of demyelination, possibly through an increase of redox active copper, or a consequence of the myelin injury. Continued DETC exposure induced an extensive degeneration of axons and myelin sheath (Wallerian degeneration in axons). DETC was not carcinogenic to rats or mice in NTP bioassay. Sodium diethyldithiocarbamate was negative when tested using Salmonella typhimurium strains (TA1535, TA1537, TA97, TA98 and TA100) in the presence and absence of metabolic activation. However, a small but significant increase in the number of chromosome breakages and aberrations was found in Vicia faba. DETC given orally to young and adult domestic fowl produced retarded testicular development, and produced degeneration in the seminiferous epithelium of mature birds. Nerve fiber degeneration was produced in the medulla and spinal cord of chicks. ECOTOXICITY STUDIES: DETC>3 mg/L applied to developing frog embryos was lethal in 24 hr. Between 1-3 mg/L caused severely malformed embryos. Retardation of growth, curvature of body axis, general edemic condition, pigmentation disorders, and abnormal notochords were noted.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

没有关于人类的数据。动物致癌性证据不足。总体评估：第3组：该物质对人类致癌性无法分类。

No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

国际癌症研究机构致癌物：二乙基二硫代氨基甲酸钠

IARC Carcinogenic Agent:Sodium diethyldithiocarbamate

来源:International Agency for Research on Cancer (IARC)

毒理性

• 致癌物分类

国际癌症研究机构（IARC）致癌物分类：第3组：无法归类其对人类致癌性

IARC Carcinogenic Classes:Group 3: Not classifiable as to its carcinogenicity to humans

来源:International Agency for Research on Cancer (IARC)

毒理性

• 致癌物分类

国际癌症研究机构专著：第12卷：（1976年）一些氨基甲酸酯、硫代氨基甲酸酯和脒基脒

IARC Monographs:Volume 12: (1976) Some Carbamates, Thiocarbamates and Carbazides

来源:International Agency for Research on Cancer (IARC)

吸收、分配和排泄

通过灌胃给予体重为1-2毫升水/千克的大鼠500毫克硫代碳酸，3小时后血浆中的硫代碳酸水平达到2毫克/升。

Rats receiving levels of 500 mg of dithiocarb in 1-2 mL water/kg body weight by gavage reached plasma levels of 2 mg/L dithiocarb in 3 hours.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

当将S-二硫代碳酸溶解在2M磷酸缓冲液中，并以25 mg/kg的剂量注射到成年雄性Wistar大鼠的小肠腔内时，确定其吸收的半衰期为26分钟。

A half life for absorption of 26 minutes was determined when S-dithiocarb dissolved in 2M phosphate buffer was injected into the small intestinal lumen of adult male Wistar rats at a dose of 25 mg/kg.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在大鼠腹腔注射25毫克(222摩尔S)/大鼠S-二硫代羧酸15分钟内，检测到血浆中存在非蛋白结合的放射性标记(1561纳摩尔/毫升血浆)和肝脏中(3211纳摩尔/克肝脏)。大量的放射性物质(>45%，在给药15分钟内)也被发现可逆地与肝脏和血浆的可溶性蛋白结合。

Within 15 minutes of dosing rats with 25 mg (222 moles S)/rat S-dithiocarb i.p., nonprotein bound radiolabel was detected in the plasma (1561 nmoles/mL plasma) and in the liver (3211 nmoles/g liver). A substantial amount (>45% within 15 minutes of dosing) of radioactivity also was found to be bound reversibly to soluble proteins of liver and plasma.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在给予大鼠25毫克/只(35)S-二硫代羧酸肌内注射后，尿液中小部分（小于0.1%）未变化的二硫代羧酸被检测到。给药后1小时，尿液中的放射性代谢物中有96.1%是S-葡萄糖苷酸结合物，3.9%是无机硫酸盐。在给药后1小时内，有7%的给予的(35)S-二硫代羧酸以二硫化碳的形式在呼出气体中被回收。

A small amount (<0.1%) of unchanged dithiocarb was detected in the urine of rats receiving ip injections of 25 mg (35)S-dithiocarb/rat. One hr after dosing, 96.1% of the radiolabeled urinary metabolites was of S-glucuronide conjugate and 3.9% inorganic sulfate. Within 1 hr after dosing, 7% of the administered (35)S-dithiocarb was recovered as carbon disulfide in the expired air.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  9
• WGK Germany：
  1
• RTECS号：
  EZ6475000
• 海关编码：
  2930909090
• 储存条件：
  | 室温 |

SDS

Name:	Diethyldithiocarbamic acid sodium salt trihydrate Material Safety Data Sheet
Synonym:	Sodium diethyldithiocarbamate trihydrate; Diethylcarbamodithioic acid sodium salt trihydrate; Dithiocarb trihydrate; DTC trihydrate; DDC trihydrate; DEDC trihydrate; DDTC trihydrate; DeDTC trihydrate; chelating agent with strong affinity for H
CAS:	148-18-5

Section 1 - Chemical Product MSDS Name:Diethyldithiocarbamic acid sodium salt trihydrate Material Safety Data Sheet
Synonym:Sodium diethyldithiocarbamate trihydrate; Diethylcarbamodithioic acid sodium salt trihydrate; Dithiocarb trihydrate; DTC trihydrate; DDC trihydrate; DEDC trihydrate; DDTC trihydrate; DeDTC trihydrate; chelating agent with strong affinity for H

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
148-18-5	Sodium diethyldithiocarbamate trihydra	>99	unlisted

Hazard Symbols: XN
Risk Phrases: 22

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful if swallowed.Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation.
Ingestion:
May be harmful if swallowed. Contact with stomach acid may liberate carbon disulfide which primarily affects the nervous, cardiovascular, and reproductive systems.
Inhalation:
Causes respiratory tract irritation.
Chronic:
May cause reproductive and fetal effects. Prolonged or repeated exposure affects the nervous system.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid breathing dust.
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Store protected from moisture. Refrigeration has been recommended.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 148-18-5: Germany: 2 mg/m3 TWA (inhalable fraction) Netherlands: 2 mg/m3 MAC CAS# 20624-25-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystalline powder
Color: very slightly yellow
Odor: Not available.
pH: 11.6 (10% aq soln)
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 95-98.5 deg C
Autoignition Temperature: Not available.
Flash Point: Not applicable.
Explosion Limits, lower: N/A
Explosion Limits, upper: N/A
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density:
Molecular Formula: C5H10NNaS2.3H2O
Molecular Weight: 225.31

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, moisture, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 148-18-5: EZ6475000 CAS# 20624-25-3: EZ6550000 LD50/LC50:
CAS# 148-18-5: Oral, mouse: LD50 = 1500 mg/kg; Oral, rabbit: LD50 = 500 mg/kg; Oral, rat: LD50 = 1500 mg/kg; Skin, rat: LD50 = >1 gm/kg.
CAS# 20624-25-3: Oral, mouse: LD50 = 1500 mg/kg; Oral, rat: LD50 = 1500 mg/kg.
Carcinogenicity:
Sodium diethyldithiocarbamate, anhydrous - Not listed by ACGIH, IARC, or NTP.
Sodium diethyldithiocarbamate trihydrate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 148-18-5: 3
CAS# 20624-25-3: 2
Canada
CAS# 148-18-5 is listed on Canada's DSL List.
CAS# 148-18-5 is not listed on Canada's Ingredient Disclosure List.
CAS# 20624-25-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 148-18-5 is listed on the TSCA inventory.
CAS# 20624-25-3 is not on the TSCA Inventory because it is a hydrate.
It is considered to be listed if the CAS number for the anhydrous form
is on the inventory (40CFR720.3(u)(2)).

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

应用

二乙基二硫代氨基甲酸钠可作为铜试剂应用于铜的显色反应，用作软金属离子的沉淀剂和溶剂萃取剂，并且也用作测定铋、铜、镍等金属的光度试剂。

试验示例 对铜适用性试验

1. 取1.0 mL水溶解试样溶液（4.3.1），稀释至10 mL。
2. 向分液漏斗中加入1.0 mL含0.001 mg Cu的铜杂质标准溶液（1 mL 溶液含Cu 0.001 mg），再加0.5 mL氨水（10%）溶液，稀释至20 mL。加入5.0 mL异戊醇并振摇1 min后静置。
3. 同时进行空白试验。

有机层应呈现黄色，并且与空白试验溶液有明显区别。

杂质测定

1. 称取试样0.01 g准确至0.01 g。
2. 水溶解试验
   • 称取0.5 g试样，加入25 mL水中，确保溶液澄清无机械杂质（保留此溶液用于对铜适用性试验的测定）。
3. 灼烧残渣
   • 取1 g试样置于650±50℃恒重的瓷舟中，缓缓加热直至炭化。冷却后用1 mL硫酸润湿残渣并继续加热至硫酸蒸气逸尽，在高温炉中于650±50℃下灼烧至恒重。
4. 残渣含量计算： [ x = \frac{m_1}{m} \times 100% ] 式中：(x) ——残渣的百分含量，%； (m_1) ——灼烧后残渣的质量，g； (m)——试样质量，g。

生物活性

二乙基二硫代氨基甲酸钠是一种铜试剂，在与Cu²⁺溶液反应时生成络合物，提高了铜置换沉淀速率，并且可以降低HIV感染率。

靶点

• HIV

体外研究

• Ditiocarb sodium (Sodium diethyldithiocarbamate) 反应与 Cu²⁺ 溶液生成铜二乙基硫代氨基甲酸盐络合物，从而加速沉淀速率。Ditiocarb sodium 具有很强的抗氧化能力和螯合作用。

体内研究

• Ditiocarb sodium (Sodium diethyldithiocarbamate) 改善新生儿和老年小鼠的免疫反应下降情况；在动物中预防顺铂引起的肾毒性，而不会降低其抗肿瘤活性。在艾滋病模型中，Ditiocarb sodium 减轻淋巴腺病和高球蛋白血症、恢复免疫功能并延长生存期。

化学性质

• 三水合物：从丙酮获得薄而无规则的片状结晶，熔点94～102℃（也有报道为90～92℃）。易溶于水，可溶于乙醇、甲醇或丙酮，不溶于乙醚或苯。其水溶液呈碱性并缓慢分解。
• UV最大吸收（在乙醇中）：257 nm 和 290 nm（ε1200, 13000）。

用途

低分子硫化物的免疫增强剂，促进T细胞成熟，增加T4细胞总量，并改善自然杀伤细胞的功能。与齐多夫定具有协同作用，用于治疗艾滋病。

反应信息

• 作为反应物：
  描述：

  sodium N,N-diethyldithiocarbamate 在 氰离子 硫酸 、 双氧水 作用下， 生成 舒非仑
  参考文献：
  名称：

  秋兰姆单硫化物作为铜 (II) 选择性膜电极的中性载体

  摘要：

  开发了对铜 (II) 离子敏感和选择性的聚（氯乙烯）膜电极。基于四甲基、四乙基和二吡咯烷秋兰姆单硫化物作为中性载体的电极，在 10-1 M 至 10-6 M-10-8 M 的活性范围内对铜 (II) 离子表现出能斯特行为。 电极的特性进行了简要讨论。

  DOI：

  10.1246/cl.1988.1247
• 作为产物：
  描述：

  1-甲基-3-苯基-2,5-二氢吡咯草酸酯 在 sodium hydrogensulfide 作用下， 以 甲醇 为溶剂， 生成 sodium N,N-diethyldithiocarbamate
  参考文献：
  名称：

  Procedure for the Preparation of Pure Dithiocarbamates

  摘要：

  DOI：

  10.1021/jo00084a046
• 作为试剂：
  描述：

  Lopac-F-9552 、 一氧化碳 、 2,4,6-三氯苯胺 在 tris-(dibenzylideneacetone)dipalladium(0) N,N-二异丙基乙胺 、 三苯基膦 、 sodium N,N-diethyldithiocarbamate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 18.17h， 生成 H-D-Thz-Phe(4-NHBz(2,6-diCl))-OMe
  参考文献：
  名称：

  Inhibitors of &agr;4&bgr;1 mediated cell adhesion

  摘要：

  本发明涉及式(I)的化合物，它们是α4β1介导的对VCAM或CS-1的黏附的有效抑制剂，可用于治疗炎症性疾病。具体来说，本发明的分子可用于治疗或预防哺乳动物，如人类，中的α4β1介导的黏附状况。该方法可能包括向哺乳动物或人类患者施用本说明书中所述的化合物或组合物的有效量。

  公开号：

  US06685617B1

文献信息

• Hg2+ sensing in aqueous solutions: an intramolecular charge transfer emission quenching fluorescent chemosensors
  作者：Sin-Man Cheung、Wing-Hong Chan

  DOI：10.1016/j.tet.2006.06.035

  日期：2006.8

  functionalities as ligating groups, were designed as fluorescent chemosensors for Hg(II). In aqueous solvent systems, upon excitation, in addition to the normal emission bands of locally excited (LE) state of anthracene, both compounds show a prominent pH-independent intramolecular charge transfer (ICT) emissive band, which can be modulated by Hg2+ binding. The systems can be exploited to develop a fluorescent

  将包含蒽部分作为荧光团和一对二硫代氨基甲酸酯官能团作为连接基团的化合物4a和4b设计为Hg（II）的荧光化学传感器。在水性溶剂系统中，在激发后，除了蒽的局部激发（LE）态的正常发射带外，两种化合物均显示出显着的非pH依赖性分子内电荷转移（ICT）发射带，可通过Hg 2+对其进行调节捆绑。可以利用该系统开发Hg 2+的荧光敏感探针。
• Cerium ammonium nitrate-catalyzed aerobic oxidative coupling of dithiocarbamates: facile synthesis of thioureas and bis(aminothiocarbonyl)disulfides
  作者：Tian-Tian Li、Xiang-Hai Song、Mei-Shuang Wang、Ning Ma

  DOI：10.1039/c4ra04628e

  日期：——

  Diverse disubstituted and trisubstituted thioureas were synthesized by the condensation of dithiocarbamate TEA (or DABCO) salts and amines using cerium ammonium nitrate (CAN) as a catalyst in high yields at room temperature. It is a one-pot method and it is unnecessary to isolate isothiocyanates. This reaction probably took place through nucleophilic addition of amines to isothiocyanates, which were generated by oxidative coupling of dithiocarbamates and the following decomposition of bis(aminothiocarbonyl)disulfides. When secondary amines and CS2 served as the reactants, bis(aminothiocarbonyl)disulfides were obtained via tandem nucleophilic addition/oxidative coupling reactions in moderate to excellent yields. In all the coupling reactions, the oxidant was air and CAN possibly acted as an SET catalyst.

  多种二取代和三取代硫脲通过二硫代氨基甲酸TEA（或DABCO）盐与胺在室温下使用硝酸铈铵（CAN）作为催化剂进行缩合反应，以高产率合成。这是一种一步法，无需分离异硫氰酸酯。该反应可能涉及胺对异硫氰酸酯的亲核加成，异硫氰酸酯是由二硫代氨基甲酸盐的氧化偶联以及随后双(氨基硫羰基)二硫化物的分解产生的。当使用二级胺和CS2作为反应物时，通过串联的亲核加成/氧化偶联反应，以中等至优异的产率获得了双(氨基硫羰基)二硫化物。在所有偶联反应中，氧化剂为空气，CAN可能作为单电子转移催化剂发挥作用。
• Enhanced catalytic activity of one-dimensional CdS @TiO2 core-shell nanocomposites for selective organic transformations under visible LED irradiation
  作者：Parvin Eskandari、Zahra Zand、Foad Kazemi、Moosa Ramdar

  DOI：10.1016/j.jphotochem.2021.113404

  日期：2021.9

  microscopy (TEM), UV–Vis spectroscopy, and UV–Vis diffuse reflectance spectroscopy (DRS). The as-synthesized sample was utilized for the selective reduction of nitro compounds to benzimidazole and anilide, and also the reduction of benzophenones to alcohol under blue LED irradiation. The 1D CdS@TiO2 CSNs exhibited enhanced photoactivity compared with the pure TiO2, CdS nanowires and commercial TiO2-P25. The

  在这项研究中，我们对通过简便方法制备的一维（1D）CdS @TiO 2核壳纳米复合材料（CSN）在可见光 LED 照射下的光催化活性感兴趣。为了合成一维 CdS@TiO 2核/壳结构，二氧化钛源（钛酸四丁酯）通过溶剂热法制备的 CdS 纳米线（NWs）表面的水蒸气传输水解。一维 CdS@TiO 2核壳纳米复合材料（CdS@TiO 2CSNs）使用X射线衍射（XRD）、扫描电子显微镜（SEM）、透射电子显微镜（TEM）、UV-Vis光谱和UV-Vis漫反射光谱（DRS）进行。合成样品用于选择性还原硝基化合物为苯并咪唑和苯胺，以及在蓝光 LED 照射下将二苯甲酮还原为醇。与纯TiO 2、CdS纳米线和商业TiO 2 -P25相比，一维CdS@TiO 2 CSNs表现出增强的光活性。对光催化剂的出色重复使用性进行了六次测试。结果表明，所制备的样品有可能为其他有机转化提供有前景的可见光驱动光催化剂。
• Syntheses and reactivity of oxorhenium(V) complexes containing tetraphenylimidodiphosphinato and dialkyldithiocarbamato ligands
  作者：Zhe Qian、Ying Zhang、Ai-Quan Jia、Hua-Tian Shi、Qian-Feng Zhang

  DOI：10.1016/j.ica.2019.119234

  日期：2020.1

  corresponding oxorhenium(V) complexes [ReOClN(Ph2PO)2}(S2CNMe2)]·CH2Cl2 (1), [ReOClN(Ph2PO)2}(S2CNEt2)] (2) and [ReOClN(Ph2PO)2}(S2CNiPr2)] (3). Reactions of [ReOCl3(PPh3)2] with an equimolar amount of iPr2NCS2Na or an excess of Et2NCS2Na in a mixed solvent of chloroform and methanol produced a mononuclear oxorhenium(V) complex [ReOCl2(S2CNiPr2)(PPh3)] (4) and a dinuclear oxorhenium(V) complex [Re2O3(S2CNEt2)4]

  摘要在氯仿和甲醇的混合溶剂中，用一当量的二烷基二硫代氨基甲酸钠R2NCS2Na（R = Me，Et，iPr）处理[ReOCl2 N（Ph2PO）2}（PPh3）]，得到相应的氧or（V）络合物[ReOCl N（Ph2PO）2}（S2CNMe2）]·CH2Cl2（1），[ReOCl N（Ph2PO）2}（S2CNEt2）]（2）和[ReOCl N（Ph2PO）2}（S2CNiPr2）]（3） 。[ReOCl3（PPh3）2]与等摩尔量的iPr2NCS2Na或过量的Et2NCS2Na在氯仿和甲醇的混合溶剂中的反应生成单核氧or（V）络合物[ReOCl2（S2CNiPr2）（PPh3）]（4）和a双核氧化or（V）络合物[Re2O3（S2CNEt2）4]（5，Tisley等人，Inorg。Nucl。Chem。Lett。7：523-526，1971； Fletcher等人，J。Chem。S
• Synthesis and reactivity of osmium and ruthenium PBP–LXL boryl pincer complexes
  作者：Caitlin M.A. McQueen、Anthony F. Hill、Manab Sharma、Suprita K. Singh、Jas S. Ward、Anthony C. Willis、Rowan D. Young

  DOI：10.1016/j.poly.2016.05.041

  日期：2016.12

  pincer complex [OsCl(CO)(PPh3)B(NCH2PPh2)2C6H4}]. This complex, and its ruthenium analogue were observed to undergo various reactions involving substitution of the chloride and triphenylphosphine co-ligands to give new complexes [MCl(CO)(CNC6H2Me3)B(NCH2PPh2)2C6H4}] (M = Ru, Os), [MH(CO)(PPh3)B(NCH2PPh2)2C6H4}] (M = Ru, Os) and [Ru(κ2-S,S′-S2CNEt2)(CO)B(NCH2PPh2)2C6H4}]. The ruthenium complex [Ru

  摘要HB（NCH2PPh2）2C6H4-1,2与[OsCl（Ph）（CO）（PPh3）2]反应，得到硼酸钳络合物[OsCl（CO）（PPh3）B（NCH2PPh2）2C6H4}]。观察到该络合物及其钌类似物发生了各种反应，包括取代氯化物和三苯基膦共配体，得到新的络合物[MCl（CO）（CNC6H2Me3）B（NCH2PPh2）2C6H4}]（M = Ru，Os） ，[MH（CO）（PPh3）B（NCH2PPh2）2C6H4}]（M = Ru，Os）和[Ru（κ2-S，S'-S2CNEt2）（CO）B（NCH2PPh2）2C6H4}]。发现钌络合物[RuH（CO）（PPh3）B（NCH2PPh2）2C6H4}]与二硫化碳和一氧化碳反应生成络合物[Ru（κ2-S，S'-S2CH）（CO）B （NCH2PPh2）2C6H4}]和[RuH（CO）2 B（NCH2PPh2）2C6H4}

表征谱图