3-Chlor-6-(2-hydroxy-ethoxy)-pyridazin | 122913-80-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Chlor-6-(2-hydroxy-ethoxy)-pyridazin
• 英文别名: 2-(6-chloro-pyridazin-3-yloxy)-ethanol；2-(6-Chlor-pyridazin-3-yloxy)-aethanol；3-(2-hydroxyethoxy)-6-chloropyridazine；2-(6-chloropyridazin-3-yl)oxyethanol
• CAS: 122913-80-8
• 化学式: C₆H₇ClN₂O₂
• 分子量: 174.587
• InChiKey: PVUHELHFJISBLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-Chlor-6-(2-hydroxy-ethoxy)-pyridazin 以52%的产率得到
  参考文献：
  名称：

  MATYUS, PETER;MAKK, NANDOR;KASZTREINER, ENDRE;JERKOVICH, GYULE, HETEROCYCLES, 29,(1989) N, C. 67-77

  摘要：

  DOI：
• 作为产物：
  描述：

  3,6-二氯哒嗪 、 乙二醇单钠盐 以70%的产率得到
  参考文献：
  名称：

  MATYUS, PETER;MAKK, NANDOR;KASZTREINER, ENDRE;JERKOVICH, GYULE, HETEROCYCLES, 29,(1989) N, C. 67-77

  摘要：

  DOI：

文献信息

• Allylthiopyridazine derivatives and process for preparing the same
  申请人：Kwon; Soon Kyoung

  公开号：US05942511A1

  公开（公告）日：1999-08-24

  The, present invention relates to a novel allylthiopyridazine derivative represented by formula (I) which exhibits a superior effect for prevention and treatment or hepatic diseases induced by toxic substances and for protection of human tissues from radiation: ##STR1## or a pharmaceutically acceptable salt thereof, in which R.sub.1 represents halogen atom, lower alkoxy, dialkylaminoalkoxy, hydroxyalkoxy, phenoxy substituted or unsubstituted with lower alkyl, benzyloxy, or phenyl, and R.sub.2 and R.sub.3 independently of one another represent hydrogen or lower alkyl, or R.sub.2 and R.sub.3 together with carbon atom to which they are attached can form a saturated or unsaturated 6-membered ring, provided that R.sub.2 and R.sub.3 are other than hydrogen when R.sub.1 is chloro; and to a process for preparing thereof and a pharmaceutical composition containing the same as an effective component.

  本发明涉及一种新型的烯丙基噻吡嗪衍生物，其化学式表示为（I），该化合物对预防和治疗由有毒物质诱导的肝脏疾病以及保护人体组织免受辐射的作用优越：##STR1##或其药用盐，其中R.sub.1代表卤原子，较低的烷氧基，二烷基氨氧基烷基，羟基烷氧基，苯氧基，取代或未取代较低烷基，苄氧基或苯基的苯氧基，而R.sub.2和R.sub.3彼此独立地表示氢或较低烷基，或R.sub.2和R.sub.3与它们连接的碳原子一起可以形成饱和或不饱和的6元环，前提是当R.sub.1为氯时，R.sub.2和R.sub.3不是氢；以及制备该化合物的方法和含有其作为有效成分的药物组合物。
• Antimalarial activity of new ethers and thioethers of dihydroartemisinin
  作者：B Venugopalan、PJ Karnik、CP Bapat、DK Chatterjee、N Iyer、D Lepcha

  DOI：10.1016/0223-5234(96)88287-0

  日期：1995.1

  Various ethers and thioethers of dihydroartemisinin were prepared by treating dihydroartemisinin with hydroxy alkyl, substituted phenol, hydroxy aralkyl, hydroxy alkynyl and hydroxy heteroalkyl or thiols in the presence of BF(3)Et(2)O. The thioethers 64 and 65 were further oxidised to the respective sulfoxides. These derivatives were tested in the Plasmodium berghei K-173-infected mice and some active compounds were tested in chloroquine-resistant P yoelii nigeriensis (NS)-infected mice. Initially the compounds were administered subcutaneously and subsequently by the oral route. The antimalarial activity of the compounds 22, 23, 36, 66 and 79 were found to be comparable to that of arteether when tested in the K-173-infected mice. These compounds also showed activity in the P y nigeriensis (NS)-infected mice.
• NOVEL ALLYLTHIOPYRIDAZINE DERIVATIVES AND PROCESS FOR PREPARING THE SAME
  申请人：Seoul Pharm. Co., Ltd.

  公开号：EP1058681B1

  公开（公告）日：2003-05-07
• US5942511A
  申请人：——

  公开号：US5942511A

  公开（公告）日：1999-08-24
• [EN] NOVEL ALLYLTHIOPYRIDAZINE DERIVATIVES AND PROCESS FOR PREPARING THE SAME<br/>[FR] NOUVEAUX DERIVES D'ALLYLTHIOPYRIDAZINE ET LEUR PROCEDE DE PREPARATION
  申请人：SEOUL PHARM. CO., LTD.

  公开号：WO1999036407A1

  公开（公告）日：1999-07-22

  (EN) The present invention relates to a novel allylthiopyridazine derivative represented by formula (I) which exhibits a superior effect for prevention and treatment of hepatic diseases induced by toxic substances and for protection of human tissues from radiation, or a pharmaceutically acceptable salt thereof, in which R1 represents halogen atom, lower alkoxy, dialkylaminoalkoxy, hydroxyalkoxy, phenoxy substituted or unsubstituted with lower alkyl, benzyloxy, or phenyl, and R2 and R3 independently of one another represent hydrogen or lower alkyl, or R2 and R3 together with carbon atom to which they are attached form a saturated or unsaturated 6-membered ring, provided that R2 and R3 are other than hydrogen when R1 is chloro; and to a process for preparing thereof and a pharmaceutical composition containing the same as an effective component.(FR) La présente invention concerne un nouveau dérivé d'allylthiopyridazine représenté par la formule (I), qui présente une efficacité supérieure en ce qui concerne la prévention et le traitement de maladies hépatiques induites par des substances toxiques et la protection de tissus humains contre les rayonnements. L'invention concerne également un sel pharmaceutiquement acceptable de ce dérivé. Dans ladite formule (I), R1 représente un atome d'halogène, alcoxy inférieur, dialkylaminoalcoxy, hydroxyalcoxy, phenoxy substitué ou non substitué par alkyle inférieur, benzyloxy, ou phényle, et R2 et R3 représentent, indépendamment l'un de l'autre, hydrogène ou alkyle inférieur, ou bien R2 et R3 forment avec l'atome de carbone auquel ils sont fixés un cycle à 6 éléments, saturé ou insaturé, à condition que R2 et R3 ne représentent pas hydrogène lorsque R1 représente chloro. L'invention concerne en outre un procédé de préparation de ce dérivé et une composition pharmaceutique contenant celui-ci comme principe actif.